MAP3K1
Summary: The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase kinase 1 | MIM:600982 | Ensembl:ENSG00000095015 | HGNC:HGNC:6848 | PA30592 | 5q11.2 |
GO terms in MAP3K1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | EXP | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | NAS | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| BP | IEA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000186 | activation of MAPKK activity |
| BP | TAS | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
| BP | NAS | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | IEP | GO:0071260 | cellular response to mechanical stimulus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: MAP3K1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP3K1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | cd40_pathway | CD40/CD40L signaling |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | ceramide_pathway | Ceramide signaling pathway |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | faspathway | FAS (CD95) signaling pathway |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | ifngpathway | IFN-gamma pathway |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | p38_mkk3_6pathway | p38 MAPK signaling pathway |
| pid | rac1_pathway | RAC1 signaling pathway |
| pid | smad2_3pathway | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| pid | tcrjnkpathway | JNK signaling in the CD4+ TCR pathway |
| pid | tnfpathway | TNF receptor signaling pathway |
| pid | trail_pathway | TRAIL signaling pathway |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
| smpdb | SMP00320 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine |
| smpdb | SMP00321 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP2571 | Polycystic Kidney Disease Pathway |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP384 | Apoptosis Modulation by HSP70 |
| wikipathways | WP3865 | RIG-I-like Receptor Signaling |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3927 | BMP Signaling Pathway in Eyelid Development |
| wikipathways | WP3941 | Oxidative Damage |
| wikipathways | WP3972 | PDGFR-beta pathway |
| wikipathways | WP400 | p38 MAPK Signaling Pathway |
| wikipathways | WP422 | MAPK Cascade |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP585 | Interferon type I signaling pathways |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| wikipathways | WP722 | Serotonin HTR1 Group and FOS Pathway |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| reactome | R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2871796 | FCERI mediated MAPK activation |
| reactome | R-HSA-2871796 | FCERI mediated MAPK activation |
| reactome | R-HSA-933542 | TRAF6 mediated NF-kB activation |
| reactome | R-HSA-933542 | TRAF6 mediated NF-kB activation |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| biocarta | at1rpathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling |
| biocarta | bcrpathway | bcr signaling pathway |
| biocarta | cd40pathway | cd40l signaling pathway |
| biocarta | ceramidepathway | ceramide signaling pathway |
| biocarta | egfpathway | egf signaling pathway |
| biocarta | faspathway | fas signaling pathway (cd95) |
| biocarta | fcer1pathway | fc epsilon receptor i signaling in mast cells |
| biocarta | gleevecpathway | inhibition of cellular proliferation by gleevec |
| biocarta | hcmvpathway | human cytomegalovirus and map kinase pathways |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | il1rpathway | signal transduction through il1r |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | malpathway | role of mal in rho-mediated activation of srf |
| biocarta | mapkpathway | mapkinase signaling pathway |
| biocarta | nfkbpathway | nf-kb signaling pathway |
| biocarta | p38mapkpathway | p38 mapk signaling pathway |
| biocarta | pdgfpathway | pdgf signaling pathway |
| biocarta | pyk2pathway | links between pyk2 and map kinases |
| biocarta | rac1pathway | rac1 cell motility signaling pathway |
| biocarta | smrtepathway | map kinase inactivation of smrt corepressor |
| biocarta | stresspathway | tnf/stress related signaling |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| biocarta | tnfr2pathway | tnfr2 signaling pathway |
| biocarta | tollpathway | toll-like receptor pathway |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD414 | MST-312 | 9 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD366 | PI-103 | 4 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD77 | Itraconazole | 6 |
| iGMDRD551 | Ponatinib | 1 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD672 | Alectinib | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD901 | ELCPK | 4 |
| iGMDRD85 | Ursolic acid | 4 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD116 | CD437 | 6 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD475 | BX 912 | 1 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD885 | Compound 110 | 1 |
| iGMDRD226 | ML006 | 1 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD260 | FQI-2 | 8 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD297 | Austocystin D | 6 |
| iGMDRD694 | HG6-64-1 | 1 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD61 | Kinetin riboside | 5 |
| iGMDRD193 | Fqi1 | 7 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD433 | Lexibulin | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAP3K1
CLASSFICATION
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