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MAP3K1

Summary: The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namemitogen-activated protein kinase kinase kinase 1 OMIM IDMIM:600982 Ensembl IDEnsembl:ENSG00000095015 HGNC IDHGNC:HGNC:6848 PHARMGKB IDPA30592 Map Location5q11.2

Gene Categories:

TUMOR SUPPRESSOR SERINE THREONINE KINASE KINASE CLINICALLY ACTIONABLE DRUGGABLE GENOME

GO terms in MAP3K1

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0004672	protein kinase activity
MF	TAS	GO:0004672	protein kinase activity
MF	EXP	GO:0004674	protein serine/threonine kinase activity
MF	IBA	GO:0004674	protein serine/threonine kinase activity
MF	NAS	GO:0004709	MAP kinase kinase kinase activity
MF	IPI	GO:0005515	protein binding

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Gene expression in normal tissue: MAP3K1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAP3K1

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Database	Pathway ID	Pathway Des.
pid	avb3_opn_pathway	Osteopontin-mediated events
pid	bcr_5pathway	BCR signaling pathway
pid	caspase_pathway	Caspase Cascade in Apoptosis
pid	cd40_pathway	CD40/CD40L signaling
pid	cdc42_pathway	CDC42 signaling events
pid	ceramide_pathway	Ceramide signaling pathway

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD505	Pevonedistat	2
iGMDRD300	Tozasertib	3
iGMDRD42	Vorinostat	2
iGMDRD414	MST-312	9

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP3K1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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