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KRAS

Summary: This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameKRAS proto-oncogene, GTPase OMIM IDMIM:190070 Ensembl IDEnsembl:ENSG00000133703 HGNC IDHGNC:HGNC:6407 PHARMGKB IDPA30196 Map Location12p12.1

Gene Categories:

SERINE THREONINE KINASE KINASE CLINICALLY ACTIONABLE

GO terms in KRAS

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	TAS	GO:0000165	MAPK cascade
BP	IEA	GO:0001889	liver development
BP	IMP	GO:0001934	positive regulation of protein phosphorylation
BP	TAS	GO:0002223	stimulatory C-type lectin receptor signaling pathway
BP	TAS	GO:0007265	Ras protein signal transduction
BP	IEA	GO:0007565	female pregnancy

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Gene expression in normal tissue: KRAS

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KRAS

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Database	Pathway ID	Pathway Des.
humancyc	PWY66-14	MAP kinase cascade
netpath	Pathway_EGFR1	EGFR1
kegg	hsa04010	MAPK signaling pathway - Homo sapiens (human)
kegg	hsa04012	ErbB signaling pathway - Homo sapiens (human)
kegg	hsa04014	Ras signaling pathway - Homo sapiens (human)
kegg	hsa04015	Rap1 signaling pathway - Homo sapiens (human)

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	7
iGMDRD894	EGFR inhibitor	4
iGMDRD472	PF-562271	2
iGMDRD505	Pevonedistat	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KRAS

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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