KRAS


Summary: This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
KRAS proto-oncogene, GTPaseMIM:190070Ensembl:ENSG00000133703HGNC:HGNC:6407PA3019612p12.1

GO terms in KRAS


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0000165MAPK cascade
BPIEAGO:0001889liver development
BPIMPGO:0001934positive regulation of protein phosphorylation
BPTASGO:0002223stimulatory C-type lectin receptor signaling pathway
BPTASGO:0007265Ras protein signal transduction
BPIEAGO:0007565female pregnancy
BPIMPGO:0008284positive regulation of cell proliferation
BPIEAGO:0008542visual learning
BPIMPGO:0010628positive regulation of gene expression
BPIEAGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0021897forebrain astrocyte development
BPIEAGO:0030036actin cytoskeleton organization
BPIMPGO:0031647regulation of protein stability
BPIEAGO:0032228regulation of synaptic transmission, GABAergic
BPIEAGO:0035022positive regulation of Rac protein signal transduction
BPIEAGO:0035900response to isolation stress
BPIEAGO:0038002endocrine signaling
BPIEAGO:0043406positive regulation of MAP kinase activity
BPIEAGO:0043524negative regulation of neuron apoptotic process
BPIEAGO:0045596negative regulation of cell differentiation
BPIEAGO:0048169regulation of long-term neuronal synaptic plasticity
BPIEAGO:0048873homeostasis of number of cells within a tissue
BPIEAGO:0051000positive regulation of nitric-oxide synthase activity
BPIEAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIEAGO:0051146striated muscle cell differentiation
BPIEAGO:0051384response to glucocorticoid
BPIEAGO:0051385response to mineralocorticoid
BPIEAGO:0060441epithelial tube branching involved in lung morphogenesis
BPIEAGO:2000774positive regulation of cellular senescence
CCIDAGO:0005737cytoplasm
CCIEAGO:0005739mitochondrion
CCIEAGO:0005829cytosol
CCTASGO:0005886plasma membrane
CCHDAGO:0005925focal adhesion
CCHDAGO:0016020membrane
CCIDAGO:0031234extrinsic component of cytoplasmic side of plasma membrane
CCIEAGO:0045121membrane raft
MFIEAGO:0003924GTPase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005525GTP binding
MFIEAGO:0019002GMP binding
MFIEAGO:0019003GDP binding
MFIEAGO:0030275LRR domain binding
MFIDAGO:0044877protein-containing complex binding

Gene expression in normal tissue: KRAS

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KRAS


DatabasePathway IDPathway Des.
humancycPWY66-14MAP kinase cascade
netpathPathway_EGFR1EGFR1
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04137Mitophagy - animal - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04213Longevity regulating pathway - multiple species - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04360Axon guidance - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04371Apelin signaling pathway - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04726Serotonergic synapse - Homo sapiens (human)
kegghsa04730Long-term depression - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa04960Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
kegghsa05034Alcoholism - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05216Thyroid cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05219Bladder cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
kegghsa05230Central carbon metabolism in cancer - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-112412SOS-mediated signalling
reactomeR-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)
reactomeR-HSA-1169092Activation of RAS in B cells
reactomeR-HSA-1226099Signaling by FGFR in disease
reactomeR-HSA-1227986Signaling by ERBB2
reactomeR-HSA-1227986Signaling by ERBB2
reactomeR-HSA-1236382Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
reactomeR-HSA-1236394Signaling by ERBB4
reactomeR-HSA-1250196SHC1 events in ERBB2 signaling
reactomeR-HSA-1250347SHC1 events in ERBB4 signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1433557Signaling by SCF-KIT
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-1643713Signaling by EGFR in Cancer
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-167044Signalling to RAS
reactomeR-HSA-167044Signalling to RAS
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-171007p38MAPK events
reactomeR-HSA-171007p38MAPK events
reactomeR-HSA-177929Signaling by EGFR
reactomeR-HSA-179812GRB2 events in EGFR signaling
reactomeR-HSA-180336SHC1 events in EGFR signaling
reactomeR-HSA-186763Downstream signal transduction
reactomeR-HSA-186797Signaling by PDGF
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187687Signalling to ERKs
reactomeR-HSA-187687Signalling to ERKs
reactomeR-HSA-190236Signaling by FGFR
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-1963640GRB2 events in ERBB2 signaling
reactomeR-HSA-1963640GRB2 events in ERBB2 signaling
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-210993Tie2 Signaling
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2172127DAP12 interactions
reactomeR-HSA-2179392EGFR Transactivation by Gastrin
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2424491DAP12 signaling
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-2428933SHC-related events triggered by IGF1R
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2871796FCERI mediated MAPK activation
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-375165NCAM signaling for neurite out-growth
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-5218921VEGFR2 mediated cell proliferation
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-5621575CD209 (DC-SIGN) signaling
reactomeR-HSA-5637810Constitutive Signaling by EGFRvIII
reactomeR-HSA-5637812Signaling by EGFRvIII in Cancer
reactomeR-HSA-5637815Signaling by Ligand-Responsive EGFR Variants in Cancer
reactomeR-HSA-5654687Downstream signaling of activated FGFR1
reactomeR-HSA-5654688SHC-mediated cascade:FGFR1
reactomeR-HSA-5654693FRS-mediated FGFR1 signaling
reactomeR-HSA-5654696Downstream signaling of activated FGFR2
reactomeR-HSA-5654699SHC-mediated cascade:FGFR2
reactomeR-HSA-5654700FRS-mediated FGFR2 signaling
reactomeR-HSA-5654704SHC-mediated cascade:FGFR3
reactomeR-HSA-5654706FRS-mediated FGFR3 signaling
reactomeR-HSA-5654708Downstream signaling of activated FGFR3
reactomeR-HSA-5654712FRS-mediated FGFR4 signaling
reactomeR-HSA-5654716Downstream signaling of activated FGFR4
reactomeR-HSA-5654719SHC-mediated cascade:FGFR4
reactomeR-HSA-5654736Signaling by FGFR1
reactomeR-HSA-5654738Signaling by FGFR2
reactomeR-HSA-5654741Signaling by FGFR3
reactomeR-HSA-5654743Signaling by FGFR4
reactomeR-HSA-5655253Signaling by FGFR2 in disease
reactomeR-HSA-5655291Signaling by FGFR4 in disease
reactomeR-HSA-5655302Signaling by FGFR1 in disease
reactomeR-HSA-5655332Signaling by FGFR3 in disease
reactomeR-HSA-5658442Regulation of RAS by GAPs
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673000RAF activation
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5674135MAP2K and MAPK activation
reactomeR-HSA-5675221Negative regulation of MAPK pathway
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6802946Signaling by moderate kinase activity BRAF mutants
reactomeR-HSA-6802948Signaling by high-kinase activity BRAF mutants
reactomeR-HSA-6802949Signaling by RAS mutants
reactomeR-HSA-6802952Signaling by BRAF and RAF fusions
reactomeR-HSA-6802953RAS signaling downstream of NF1 loss-of-function variants
reactomeR-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAF
reactomeR-HSA-6802957Oncogenic MAPK signaling
reactomeR-HSA-6806834Signaling by MET
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-881907Gastrin-CREB signalling pathway via PKC and MAPK
reactomeR-HSA-8848021Signaling by PTK6
reactomeR-HSA-8849471PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
reactomeR-HSA-8851805MET activates RAS signaling
reactomeR-HSA-8853334Signaling by FGFR3 fusions in cancer
reactomeR-HSA-8853338Signaling by FGFR3 point mutants in cancer
reactomeR-HSA-8878159Transcriptional regulation by RUNX3
reactomeR-HSA-8951936RUNX3 regulates p14-ARF
reactomeR-HSA-9006115Signaling by NTRK2 (TRKB)
reactomeR-HSA-9006927Signaling by Non-Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9026519Activated NTRK2 signals through RAS
reactomeR-HSA-9028731Activated NTRK2 signals through FRS2 and FRS3
reactomeR-HSA-9034015Signaling by NTRK3 (TRKC)
reactomeR-HSA-9034864Activated NTRK3 signals through RAS
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
biocartatelpathwaytelomeres telomerase cellular aging and immortality
pharmgkbPA154423660Bisphosphonate Pathway, Pharmacodynamics
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
pharmgkbPA165959425Pathway_PA165959425
pharmgkbPA165959584Sorafenib Pharmacodynamics
pharmgkbPA165980050Vemurafenib Pathway, Pharmacodynamics
pharmgkbPA165980050update your name in edit mode
pharmgkbPA2032VEGF Signaling Pathway
pidcd8tcrdownstreampathwayDownstream signaling in naïve CD8+ T cells
pidcd8tcrpathwayTCR signaling in naïve CD8+ T cells
pidcmyb_pathwayC-MYB transcription factor network
pidcxcr3pathwayCXCR3-mediated signaling events
pidephbfwdpathwayEPHB forward signaling
pider_nongenomic_pathwayPlasma membrane estrogen receptor signaling
piderbb1_downstream_pathwayErbB1 downstream signaling
piderbb1_internalization_pathwayInternalization of ErbB1
piderbb2erbb3pathwayErbB2/ErbB3 signaling events
pidgmcsf_pathwayGMCSF-mediated signaling events
pidil2_1pathwayIL2-mediated signaling events
pidmapktrkpathwayTrk receptor signaling mediated by the MAPK pathway
pidmtor_4pathwaymTOR signaling pathway
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidpi3kcipathwayClass I PI3K signaling events
pidpi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
pidras_pathwayRegulation of Ras family activation
pidshp2_pathwaySHP2 signaling
pidtcr_pathwayTCR signaling in naïve CD4+ T cells
pidtcrraspathwayRas signaling in the CD4+ TCR pathway
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling
wikipathwaysWP127IL-5 Signaling Pathway
wikipathwaysWP1984Integrated Breast Cancer Pathway
wikipathwaysWP1993Angiogenesis overview
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2290RalA downstream regulated genes
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP2586Aryl Hydrocarbon Receptor
wikipathwaysWP2870Extracellular vesicle-mediated signaling in recipient cells
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP35G Protein Signaling Pathways
wikipathwaysWP3676BDNF-TrkB Signaling
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3844PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3981miRNA regulation of prostate cancer signaling pathways
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4205MET in type 1 papillary renal cell carcinoma
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP422MAPK Cascade
wikipathwaysWP4223Ras Signaling
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP51Regulation of Actin Cytoskeleton
wikipathwaysWP673ErbB Signaling Pathway
wikipathwaysWP710DNA Damage Response (only ATM dependent)
wikipathwaysWP732Serotonin Receptor 2 and ELK-SRF-GATA4 signaling
smpdbSMP00358Fc Epsilon Receptor I Signaling in Mast Cells

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259017
iGMDRD894EGFR inhibitor4
iGMDRD472PF-5622712
iGMDRD505Pevonedistat1
iGMDRD300Tozasertib2
iGMDRD80Irinotecan1
iGMDRD872BRD71373
iGMDRD459RO-33061
iGMDRD68Paclitaxel2
iGMDRD389SB5253341
iGMDRD565BI-D18701
iGMDRD746CDK9 Inhibitor1
iGMDRD51BH32
iGMDRD901ELCPK1
iGMDRD49716beta-Bromoandrosterone1
iGMDRD456Crizotinib2
iGMDRD299ICL 6702
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD347Y-399831
iGMDRD898EGFR mAb inhibitor4
iGMDRD1020Trastuzumab3
iGMDRD262KU-559331
iGMDRD360SB-5051241
iGMDRD835BET inhibitor2
iGMDRD131Erlotinib7
iGMDRD562Navitoclax3
iGMDRD596Vemurafenib1
iGMDRD870BRD636102
iGMDRD574Ruxolitinib1
iGMDRD782DC-45-A23
iGMDRD586Ridaforolimus1
iGMDRD907EZH2 inhibitor1
iGMDRD109Gefitinib9
iGMDRD836BET inhibitors in LKB1 wt2
iGMDRD916Genentech Cpd 101
iGMDRD509NVP-BHG7121
iGMDRD491TAE-6841
iGMDRD422Regorafenib10
iGMDRD634SCHEMBL26080413
iGMDRD824Atezolizumab4
iGMDRD806Adoptive T-cell Transfer1
iGMDRD181CDK4 inhibitor1
iGMDRD348BMS-3455411
iGMDRD401Afatinib5
iGMDRD603GDC-06231
iGMDRD193Fqi11
iGMDRD696NG252
iGMDRD519GDC-09411
iGMDRD608Refametinib8
iGMDRD201SKI II1
iGMDRD678Tubastatin A1
iGMDRD63Camptothecin1
iGMDRD239Dasatinib2
iGMDRD328AR-421
iGMDRD659Avagacestat (BMS-708163)1
iGMDRD772BRD47703
iGMDRD1008SR-II-138A2
iGMDRD136Nutlin-31
iGMDRD313Axitinib1
iGMDRD245FH5351
iGMDRD209BRD63402
iGMDRD329Merck603
iGMDRD968Pan-RAF inhibitor4
iGMDRD839BRAF inhibitor2
iGMDRD286Nsc 6328394
iGMDRD934JAK/TBK1/IKK? inhibitor2
iGMDRD705Nakiterpiosin1
iGMDRD288Carboplatin2
iGMDRD402AKT Inhibitor VIII2
iGMDRD605AZD64821
iGMDRD176Decitabine3
iGMDRD511CHEMBL3993797
iGMDRD73NSC-2078951
iGMDRD461VX-11e1
iGMDRD376Tivozanib1
iGMDRD341Triacsin c5
iGMDRD405PIK-754
iGMDRD532Olaparib1
iGMDRD324CI-10402
iGMDRD910FAK inhibitor2
iGMDRD896EGFR inhibitor 2nd gen1
iGMDRD41Imatinib1
iGMDRD369TGX-1151
iGMDRD190Nilotinib1
iGMDRD506Fedratinib2
iGMDRD780PP-3010
iGMDRD188Piperlongumine2
iGMDRD31Sarcolysin16
iGMDRD74Idarubicin1
iGMDRD399Selumetinib21
iGMDRD593CX-54611
iGMDRD52Rotenone3
iGMDRD983PI3K pathway inhibitor19
iGMDRD171Pemetrexed3
iGMDRD284Palbociclib4
iGMDRD117Docetaxel6
iGMDRD665G-5731
iGMDRD449RO49876552
iGMDRD694HG6-64-11
iGMDRD394BX-7952
iGMDRD2PK-111952
iGMDRD152179324-69-71
iGMDRD135Lenalidomide1
iGMDRD283Bosutinib1
iGMDRD899EGFR TK inhibitor1
iGMDRD484Pluripotin4
iGMDRD781Sirolimus3
iGMDRD126Tipifarnib2
iGMDRD151CHM-12
iGMDRD895EGFR inhibitor 1st gen1
iGMDRD695FR-1802041
iGMDRD556Quizartinib1
iGMDRD42Vorinostat1
iGMDRD876CDK4/CDK6 inhibitor (abemaciclib)1
iGMDRD967Panitumumab24
iGMDRD650Abemaciclib4
iGMDRD3PD-1730741
iGMDRD688AZD81861
iGMDRD837Bevacizumab1
iGMDRD882CIL415
iGMDRD333MEK Inhibitor59
iGMDRD481Dactolisib2
iGMDRD551Ponatinib2
iGMDRD6AM-5802
iGMDRD434BMS-53692412
iGMDRD582MLN 22381
iGMDRD832BCL2 inhibitor2
iGMDRD514ERK inhibitor2
iGMDRD785XMD15-271
iGMDRD166IMO1
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD211(1S,3R)-RSL31
iGMDRD336MEK Inhibitor/anti-EGFR mAb1
iGMDRD177Teniposide6
iGMDRD536PLX-47201
iGMDRD85Ursolic acid2
iGMDRD500Cobimetinib4
iGMDRD116CD4372
iGMDRD160Cis-Platin1
iGMDRD792Cetuximab32
iGMDRD148Pifithrin-mu1
iGMDRD307Manumycin A3
iGMDRD454JNK Inhibitor VIII1
iGMDRD268Cerulenin5
iGMDRD291AC1NS4S01
iGMDRD692SB5908851
iGMDRD440Nutlin-3A1
iGMDRD921HSP90 inhibitor (in combination)4
iGMDRD30917AAG1
iGMDRD134Sorafenib5
iGMDRD375GW-4058332
iGMDRD297Austocystin D1
iGMDRD378ZM-4474391
iGMDRD737JNK-IN-21
iGMDRD253Vincaleukoblastine1
iGMDRD462OSI-906 (Linsitinib)3
iGMDRD144NSC953973
iGMDRD599Salermide3
iGMDRD995R15071
iGMDRD957NOTCH1 Antibody1
iGMDRD662JQ-12
iGMDRD119Temsirolimus2
iGMDRD993QL-XII-611
iGMDRD871BRD63686
iGMDRD311Dacinostat1
iGMDRD788ARS-8531
iGMDRD5Tyrphostin AG 14782
iGMDRD925IGF1R inhibitor2
iGMDRD672Alectinib2
iGMDRD949mTOR inhibitor2
iGMDRD103SN-383
iGMDRD202Curcumin2
iGMDRD293Bleomycin3
iGMDRD121GMX17781
iGMDRD158NSC1415407
iGMDRD365FAS inhibitor3
iGMDRD1002rTRAIL1
iGMDRD154NSC237663
iGMDRD879chemotherapy1
iGMDRD123Isoevodiamine4
iGMDRD352PD-03259011
iGMDRD237ABT-7511
iGMDRD775NCGC00346967-012
iGMDRD296Farnesylthiosalicylic acid1
iGMDRD1018TL-1-851
iGMDRD276AS 6052401
iGMDRD79Gemcitabine6
iGMDRD560MK-22061
iGMDRD356PNU-746541
iGMDRD888Compound 442
iGMDRD133Lapatinib4
iGMDRD516Z-LLNle-CHO1
iGMDRD464RAF2652
iGMDRD468AZ6282
iGMDRD833BCL-XL inhibitor2
iGMDRD207Capsaicin2
iGMDRD816anti-EGFR mAbs3
iGMDRD260FQI-21
iGMDRD553SCH7729841
iGMDRD510AZD-54381
iGMDRD259EX-5271
iGMDRD470Trametinib15
iGMDRD363OSI-9301
iGMDRD748PHA-6657521
iGMDRD61Kinetin riboside12
iGMDRD483SCH-5290742
iGMDRD546BMS-7548072
iGMDRD670ML 2101
iGMDRD889Compound 7d-cis1
iGMDRD749ZINC67184532
iGMDRD76Simvastatin3
iGMDRD433Lexibulin1
iGMDRD409Saracatinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KRAS

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