KRAS
Summary: This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| KRAS proto-oncogene, GTPase | MIM:190070 | Ensembl:ENSG00000133703 | HGNC:HGNC:6407 | PA30196 | 12p12.1 |
GO terms in KRAS
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0001889 | liver development |
| BP | IMP | GO:0001934 | positive regulation of protein phosphorylation |
| BP | TAS | GO:0002223 | stimulatory C-type lectin receptor signaling pathway |
| BP | TAS | GO:0007265 | Ras protein signal transduction |
| BP | IEA | GO:0007565 | female pregnancy |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0008542 | visual learning |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | IEA | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0021897 | forebrain astrocyte development |
| BP | IEA | GO:0030036 | actin cytoskeleton organization |
| BP | IMP | GO:0031647 | regulation of protein stability |
| BP | IEA | GO:0032228 | regulation of synaptic transmission, GABAergic |
| BP | IEA | GO:0035022 | positive regulation of Rac protein signal transduction |
| BP | IEA | GO:0035900 | response to isolation stress |
| BP | IEA | GO:0038002 | endocrine signaling |
| BP | IEA | GO:0043406 | positive regulation of MAP kinase activity |
| BP | IEA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IEA | GO:0045596 | negative regulation of cell differentiation |
| BP | IEA | GO:0048169 | regulation of long-term neuronal synaptic plasticity |
| BP | IEA | GO:0048873 | homeostasis of number of cells within a tissue |
| BP | IEA | GO:0051000 | positive regulation of nitric-oxide synthase activity |
| BP | IEA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IEA | GO:0051146 | striated muscle cell differentiation |
| BP | IEA | GO:0051384 | response to glucocorticoid |
| BP | IEA | GO:0051385 | response to mineralocorticoid |
| BP | IEA | GO:0060441 | epithelial tube branching involved in lung morphogenesis |
| BP | IEA | GO:2000774 | positive regulation of cellular senescence |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| CC | IEA | GO:0045121 | membrane raft |
| MF | IEA | GO:0003924 | GTPase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005525 | GTP binding |
| MF | IEA | GO:0019002 | GMP binding |
| MF | IEA | GO:0019003 | GDP binding |
| MF | IEA | GO:0030275 | LRR domain binding |
| MF | IDA | GO:0044877 | protein-containing complex binding |
Gene expression in normal tissue: KRAS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KRAS
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| humancyc | PWY66-14 | MAP kinase cascade |
| netpath | Pathway_EGFR1 | EGFR1 |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04137 | Mitophagy - animal - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| kegg | hsa04730 | Long-term depression - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04916 | Melanogenesis - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa04960 | Aldosterone-regulated sodium reabsorption - Homo sapiens (human) |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| kegg | hsa05213 | Endometrial cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05216 | Thyroid cancer - Homo sapiens (human) |
| kegg | hsa05218 | Melanoma - Homo sapiens (human) |
| kegg | hsa05219 | Bladder cancer - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| kegg | hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-112399 | IRS-mediated signalling |
| reactome | R-HSA-112412 | SOS-mediated signalling |
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1169092 | Activation of RAS in B cells |
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants |
| reactome | R-HSA-1236394 | Signaling by ERBB4 |
| reactome | R-HSA-1250196 | SHC1 events in ERBB2 signaling |
| reactome | R-HSA-1250347 | SHC1 events in ERBB4 signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643713 | Signaling by EGFR in Cancer |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-167044 | Signalling to RAS |
| reactome | R-HSA-167044 | Signalling to RAS |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-171007 | p38MAPK events |
| reactome | R-HSA-171007 | p38MAPK events |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-179812 | GRB2 events in EGFR signaling |
| reactome | R-HSA-180336 | SHC1 events in EGFR signaling |
| reactome | R-HSA-186763 | Downstream signal transduction |
| reactome | R-HSA-186797 | Signaling by PDGF |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187687 | Signalling to ERKs |
| reactome | R-HSA-187687 | Signalling to ERKs |
| reactome | R-HSA-190236 | Signaling by FGFR |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-1963640 | GRB2 events in ERBB2 signaling |
| reactome | R-HSA-1963640 | GRB2 events in ERBB2 signaling |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-210993 | Tie2 Signaling |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2172127 | DAP12 interactions |
| reactome | R-HSA-2179392 | EGFR Transactivation by Gastrin |
| reactome | R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| reactome | R-HSA-2424491 | DAP12 signaling |
| reactome | R-HSA-2428924 | IGF1R signaling cascade |
| reactome | R-HSA-2428928 | IRS-related events triggered by IGF1R |
| reactome | R-HSA-2428933 | SHC-related events triggered by IGF1R |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2871796 | FCERI mediated MAPK activation |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-375165 | NCAM signaling for neurite out-growth |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-5218921 | VEGFR2 mediated cell proliferation |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-5621575 | CD209 (DC-SIGN) signaling |
| reactome | R-HSA-5637810 | Constitutive Signaling by EGFRvIII |
| reactome | R-HSA-5637812 | Signaling by EGFRvIII in Cancer |
| reactome | R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer |
| reactome | R-HSA-5654687 | Downstream signaling of activated FGFR1 |
| reactome | R-HSA-5654688 | SHC-mediated cascade:FGFR1 |
| reactome | R-HSA-5654693 | FRS-mediated FGFR1 signaling |
| reactome | R-HSA-5654696 | Downstream signaling of activated FGFR2 |
| reactome | R-HSA-5654699 | SHC-mediated cascade:FGFR2 |
| reactome | R-HSA-5654700 | FRS-mediated FGFR2 signaling |
| reactome | R-HSA-5654704 | SHC-mediated cascade:FGFR3 |
| reactome | R-HSA-5654706 | FRS-mediated FGFR3 signaling |
| reactome | R-HSA-5654708 | Downstream signaling of activated FGFR3 |
| reactome | R-HSA-5654712 | FRS-mediated FGFR4 signaling |
| reactome | R-HSA-5654716 | Downstream signaling of activated FGFR4 |
| reactome | R-HSA-5654719 | SHC-mediated cascade:FGFR4 |
| reactome | R-HSA-5654736 | Signaling by FGFR1 |
| reactome | R-HSA-5654738 | Signaling by FGFR2 |
| reactome | R-HSA-5654741 | Signaling by FGFR3 |
| reactome | R-HSA-5654743 | Signaling by FGFR4 |
| reactome | R-HSA-5655253 | Signaling by FGFR2 in disease |
| reactome | R-HSA-5655291 | Signaling by FGFR4 in disease |
| reactome | R-HSA-5655302 | Signaling by FGFR1 in disease |
| reactome | R-HSA-5655332 | Signaling by FGFR3 in disease |
| reactome | R-HSA-5658442 | Regulation of RAS by GAPs |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673000 | RAF activation |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5674135 | MAP2K and MAPK activation |
| reactome | R-HSA-5675221 | Negative regulation of MAPK pathway |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants |
| reactome | R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants |
| reactome | R-HSA-6802949 | Signaling by RAS mutants |
| reactome | R-HSA-6802952 | Signaling by BRAF and RAF fusions |
| reactome | R-HSA-6802953 | RAS signaling downstream of NF1 loss-of-function variants |
| reactome | R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| reactome | R-HSA-6802957 | Oncogenic MAPK signaling |
| reactome | R-HSA-6806834 | Signaling by MET |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74751 | Insulin receptor signalling cascade |
| reactome | R-HSA-74752 | Signaling by Insulin receptor |
| reactome | R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK |
| reactome | R-HSA-8848021 | Signaling by PTK6 |
| reactome | R-HSA-8849471 | PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases |
| reactome | R-HSA-8851805 | MET activates RAS signaling |
| reactome | R-HSA-8853334 | Signaling by FGFR3 fusions in cancer |
| reactome | R-HSA-8853338 | Signaling by FGFR3 point mutants in cancer |
| reactome | R-HSA-8878159 | Transcriptional regulation by RUNX3 |
| reactome | R-HSA-8951936 | RUNX3 regulates p14-ARF |
| reactome | R-HSA-9006115 | Signaling by NTRK2 (TRKB) |
| reactome | R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9026519 | Activated NTRK2 signals through RAS |
| reactome | R-HSA-9028731 | Activated NTRK2 signals through FRS2 and FRS3 |
| reactome | R-HSA-9034015 | Signaling by NTRK3 (TRKC) |
| reactome | R-HSA-9034864 | Activated NTRK3 signals through RAS |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| biocarta | telpathway | telomeres telomerase cellular aging and immortality |
| pharmgkb | PA154423660 | Bisphosphonate Pathway, Pharmacodynamics |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA165959425 | Pathway_PA165959425 |
| pharmgkb | PA165959584 | Sorafenib Pharmacodynamics |
| pharmgkb | PA165980050 | Vemurafenib Pathway, Pharmacodynamics |
| pharmgkb | PA165980050 | update your name in edit mode |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | cmyb_pathway | C-MYB transcription factor network |
| pid | cxcr3pathway | CXCR3-mediated signaling events |
| pid | ephbfwdpathway | EPHB forward signaling |
| pid | er_nongenomic_pathway | Plasma membrane estrogen receptor signaling |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | erbb1_internalization_pathway | Internalization of ErbB1 |
| pid | erbb2erbb3pathway | ErbB2/ErbB3 signaling events |
| pid | gmcsf_pathway | GMCSF-mediated signaling events |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | mapktrkpathway | Trk receptor signaling mediated by the MAPK pathway |
| pid | mtor_4pathway | mTOR signaling pathway |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | pi3kcipathway | Class I PI3K signaling events |
| pid | pi3kplctrkpathway | Trk receptor signaling mediated by PI3K and PLC-gamma |
| pid | ras_pathway | Regulation of Ras family activation |
| pid | shp2_pathway | SHP2 signaling |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| pid | tcrraspathway | Ras signaling in the CD4+ TCR pathway |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP1984 | Integrated Breast Cancer Pathway |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2290 | RalA downstream regulated genes |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2586 | Aryl Hydrocarbon Receptor |
| wikipathways | WP2870 | Extracellular vesicle-mediated signaling in recipient cells |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP35 | G Protein Signaling Pathways |
| wikipathways | WP3676 | BDNF-TrkB Signaling |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3844 | PI3K-AKT-mTOR signaling pathway and therapeutic opportunities |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP3981 | miRNA regulation of prostate cancer signaling pathways |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4205 | MET in type 1 papillary renal cell carcinoma |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP422 | MAPK Cascade |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP673 | ErbB Signaling Pathway |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| wikipathways | WP732 | Serotonin Receptor 2 and ELK-SRF-GATA4 signaling |
| smpdb | SMP00358 | Fc Epsilon Receptor I Signaling in Mast Cells |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 7 |
| iGMDRD894 | EGFR inhibitor | 4 |
| iGMDRD472 | PF-562271 | 2 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD80 | Irinotecan | 1 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD459 | RO-3306 | 1 |
| iGMDRD68 | Paclitaxel | 2 |
| iGMDRD389 | SB525334 | 1 |
| iGMDRD565 | BI-D1870 | 1 |
| iGMDRD746 | CDK9 Inhibitor | 1 |
| iGMDRD51 | BH3 | 2 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD497 | 16beta-Bromoandrosterone | 1 |
| iGMDRD456 | Crizotinib | 2 |
| iGMDRD299 | ICL 670 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD347 | Y-39983 | 1 |
| iGMDRD898 | EGFR mAb inhibitor | 4 |
| iGMDRD1020 | Trastuzumab | 3 |
| iGMDRD262 | KU-55933 | 1 |
| iGMDRD360 | SB-505124 | 1 |
| iGMDRD835 | BET inhibitor | 2 |
| iGMDRD131 | Erlotinib | 7 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD596 | Vemurafenib | 1 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD574 | Ruxolitinib | 1 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD586 | Ridaforolimus | 1 |
| iGMDRD907 | EZH2 inhibitor | 1 |
| iGMDRD109 | Gefitinib | 9 |
| iGMDRD836 | BET inhibitors in LKB1 wt | 2 |
| iGMDRD916 | Genentech Cpd 10 | 1 |
| iGMDRD509 | NVP-BHG712 | 1 |
| iGMDRD491 | TAE-684 | 1 |
| iGMDRD422 | Regorafenib | 10 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD824 | Atezolizumab | 4 |
| iGMDRD806 | Adoptive T-cell Transfer | 1 |
| iGMDRD181 | CDK4 inhibitor | 1 |
| iGMDRD348 | BMS-345541 | 1 |
| iGMDRD401 | Afatinib | 5 |
| iGMDRD603 | GDC-0623 | 1 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD696 | NG25 | 2 |
| iGMDRD519 | GDC-0941 | 1 |
| iGMDRD608 | Refametinib | 8 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD678 | Tubastatin A | 1 |
| iGMDRD63 | Camptothecin | 1 |
| iGMDRD239 | Dasatinib | 2 |
| iGMDRD328 | AR-42 | 1 |
| iGMDRD659 | Avagacestat (BMS-708163) | 1 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD136 | Nutlin-3 | 1 |
| iGMDRD313 | Axitinib | 1 |
| iGMDRD245 | FH535 | 1 |
| iGMDRD209 | BRD6340 | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD968 | Pan-RAF inhibitor | 4 |
| iGMDRD839 | BRAF inhibitor | 2 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD934 | JAK/TBK1/IKK? inhibitor | 2 |
| iGMDRD705 | Nakiterpiosin | 1 |
| iGMDRD288 | Carboplatin | 2 |
| iGMDRD402 | AKT Inhibitor VIII | 2 |
| iGMDRD605 | AZD6482 | 1 |
| iGMDRD176 | Decitabine | 3 |
| iGMDRD511 | CHEMBL399379 | 7 |
| iGMDRD73 | NSC-207895 | 1 |
| iGMDRD461 | VX-11e | 1 |
| iGMDRD376 | Tivozanib | 1 |
| iGMDRD341 | Triacsin c | 5 |
| iGMDRD405 | PIK-75 | 4 |
| iGMDRD532 | Olaparib | 1 |
| iGMDRD324 | CI-1040 | 2 |
| iGMDRD910 | FAK inhibitor | 2 |
| iGMDRD896 | EGFR inhibitor 2nd gen | 1 |
| iGMDRD41 | Imatinib | 1 |
| iGMDRD369 | TGX-115 | 1 |
| iGMDRD190 | Nilotinib | 1 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD780 | PP-30 | 10 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD31 | Sarcolysin | 16 |
| iGMDRD74 | Idarubicin | 1 |
| iGMDRD399 | Selumetinib | 21 |
| iGMDRD593 | CX-5461 | 1 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD983 | PI3K pathway inhibitor | 19 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD284 | Palbociclib | 4 |
| iGMDRD117 | Docetaxel | 6 |
| iGMDRD665 | G-573 | 1 |
| iGMDRD449 | RO4987655 | 2 |
| iGMDRD694 | HG6-64-1 | 1 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD2 | PK-11195 | 2 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD135 | Lenalidomide | 1 |
| iGMDRD283 | Bosutinib | 1 |
| iGMDRD899 | EGFR TK inhibitor | 1 |
| iGMDRD484 | Pluripotin | 4 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD895 | EGFR inhibitor 1st gen | 1 |
| iGMDRD695 | FR-180204 | 1 |
| iGMDRD556 | Quizartinib | 1 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD876 | CDK4/CDK6 inhibitor (abemaciclib) | 1 |
| iGMDRD967 | Panitumumab | 24 |
| iGMDRD650 | Abemaciclib | 4 |
| iGMDRD3 | PD-173074 | 1 |
| iGMDRD688 | AZD8186 | 1 |
| iGMDRD837 | Bevacizumab | 1 |
| iGMDRD882 | CIL41 | 5 |
| iGMDRD333 | MEK Inhibitor | 59 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD551 | Ponatinib | 2 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD434 | BMS-536924 | 12 |
| iGMDRD582 | MLN 2238 | 1 |
| iGMDRD832 | BCL2 inhibitor | 2 |
| iGMDRD514 | ERK inhibitor | 2 |
| iGMDRD785 | XMD15-27 | 1 |
| iGMDRD166 | IMO | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 1 |
| iGMDRD336 | MEK Inhibitor/anti-EGFR mAb | 1 |
| iGMDRD177 | Teniposide | 6 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD500 | Cobimetinib | 4 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD160 | Cis-Platin | 1 |
| iGMDRD792 | Cetuximab | 32 |
| iGMDRD148 | Pifithrin-mu | 1 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD454 | JNK Inhibitor VIII | 1 |
| iGMDRD268 | Cerulenin | 5 |
| iGMDRD291 | AC1NS4S0 | 1 |
| iGMDRD692 | SB590885 | 1 |
| iGMDRD440 | Nutlin-3A | 1 |
| iGMDRD921 | HSP90 inhibitor (in combination) | 4 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD134 | Sorafenib | 5 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD378 | ZM-447439 | 1 |
| iGMDRD737 | JNK-IN-2 | 1 |
| iGMDRD253 | Vincaleukoblastine | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD995 | R1507 | 1 |
| iGMDRD957 | NOTCH1 Antibody | 1 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD119 | Temsirolimus | 2 |
| iGMDRD993 | QL-XII-61 | 1 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD311 | Dacinostat | 1 |
| iGMDRD788 | ARS-853 | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD925 | IGF1R inhibitor | 2 |
| iGMDRD672 | Alectinib | 2 |
| iGMDRD949 | mTOR inhibitor | 2 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD293 | Bleomycin | 3 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD158 | NSC141540 | 7 |
| iGMDRD365 | FAS inhibitor | 3 |
| iGMDRD1002 | rTRAIL | 1 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD879 | chemotherapy | 1 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD775 | NCGC00346967-01 | 2 |
| iGMDRD296 | Farnesylthiosalicylic acid | 1 |
| iGMDRD1018 | TL-1-85 | 1 |
| iGMDRD276 | AS 605240 | 1 |
| iGMDRD79 | Gemcitabine | 6 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD133 | Lapatinib | 4 |
| iGMDRD516 | Z-LLNle-CHO | 1 |
| iGMDRD464 | RAF265 | 2 |
| iGMDRD468 | AZ628 | 2 |
| iGMDRD833 | BCL-XL inhibitor | 2 |
| iGMDRD207 | Capsaicin | 2 |
| iGMDRD816 | anti-EGFR mAbs | 3 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD553 | SCH772984 | 1 |
| iGMDRD510 | AZD-5438 | 1 |
| iGMDRD259 | EX-527 | 1 |
| iGMDRD470 | Trametinib | 15 |
| iGMDRD363 | OSI-930 | 1 |
| iGMDRD748 | PHA-665752 | 1 |
| iGMDRD61 | Kinetin riboside | 12 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD670 | ML 210 | 1 |
| iGMDRD889 | Compound 7d-cis | 1 |
| iGMDRD749 | ZINC6718453 | 2 |
| iGMDRD76 | Simvastatin | 3 |
| iGMDRD433 | Lexibulin | 1 |
| iGMDRD409 | Saracatinib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KRAS
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.