iGMDRD738

Canonical SMILES: CC(C)N1C2=C(C(=C3C=C4C=C(C=CC4=N3)O)N1)C(=NC=N2)N

InChI: InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,21,23H,1-2H3,(H2,17,18,19)

InChI Key: MTICIDWIKCANDD-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NamePP-242
CHEMBLCHEMBL1241674
Pubchem CID57347700
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: Colorectal Cancer model num: 1BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 4

Drug-gene pathway enrichments

8reactome: Signal Transduction6reactome: Signaling by Receptor Tyrosine Kinases5netpath: EGFR15reactome: Immune System5kegg: PI3K-Akt signaling pathway - Homo sapiens (human)4wikipathways: Focal Adhesion4wikipathways: Signaling Pathways in Glioblastoma4wikipathways: Endometrial cancer4wikipathways: DNA Damage Response (only ATM dependent)4reactome: Disease

Drug-gene GO enrichments

7CC: cytosol6CC: cytoplasm6CC: plasma membrane5MF: protein binding5BP: phosphatidylinositol phosphorylation4MF: 1-phosphatidylinositol-3-kinase activity4MF: phosphatidylinositol-4,5-bisphosphate 3-kinase activity4BP: phosphatidylinositol 3-kinase signaling4MF: protein tyrosine kinase activity4CC: phosphatidylinositol 3-kinase complex

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
5295 PIK3R1 1
2064 ERBB2 1
1978 EIF4EBP1 1
5290 PIK3CA 1
Showing 1 to 4 of 5 rows

Gene in drug-gene network: Network Plot

Models in PP-242

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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