EIF4EBP1


Summary: This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
eukaryotic translation initiation factor 4E binding protein 1MIM:602223Ensembl:ENSG00000187840HGNC:HGNC:3288PA277158p11.23

Gene Categories:

TUMOR SUPPRESSOR

GO terms in EIF4EBP1


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
BPIMPGO:0000082G1/S transition of mitotic cell cycle
BPIEAGO:0002192IRES-dependent translational initiation of linear mRNA
BPIEAGO:0008286insulin receptor signaling pathway
BPIDAGO:0031929TOR signaling
BPIMPGO:0045931positive regulation of mitotic cell cycle
BPIBAGO:0045947negative regulation of translational initiation
BPIDAGO:0045947negative regulation of translational initiation
BPIEAGO:0071549cellular response to dexamethasone stimulus
MFIPIGO:0005515protein binding
MFIBAGO:0008190eukaryotic initiation factor 4E binding
MFIDAGO:0008190eukaryotic initiation factor 4E binding
MFIDAGO:0030371translation repressor activity

Gene expression in normal tissue: EIF4EBP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EIF4EBP1


DatabasePathway IDPathway Des.
wikipathwaysWP107Translation Factors
wikipathwaysWP1403AMP-activated Protein Kinase (AMPK) Signaling
wikipathwaysWP1471Target Of Rapamycin (TOR) Signaling
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2035Follicle Stimulating Hormone (FSH) signaling pathway
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP2203Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathwaysWP2263Androgen Receptor Network in Prostate Cancer
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP244Alpha 6 Beta 4 signaling pathway
wikipathwaysWP2593JAK-STAT
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP3676BDNF-TrkB Signaling
wikipathwaysWP3844PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
wikipathwaysWP38794-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP516Hypertrophy Model
wikipathwaysWP585Interferon type I signaling pathways
wikipathwaysWP673ErbB Signaling Pathway
smpdbSMP00682Leucine Stimulation on Insulin Signaling
netpathPathway_Alpha6Beta4IntegrinAlpha6Beta4Integrin
netpathPathway_BCRBCR
netpathPathway_EGFR1EGFR1
netpathPathway_IL2IL2
netpathPathway_IL6IL6
netpathPathway_KitReceptorKitReceptor
netpathPathway_LeptinLeptin
pidinsulin_pathwayInsulin Pathway
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pidmtor_4pathwaymTOR signaling pathway
pidp38alphabetadownstreampathwaySignaling mediated by p38-alpha and p38-beta
kegghsa03013RNA transport - Homo sapiens (human)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
biocartaeif4pathwayregulation of eif-4e and p70s6 kinase
biocartaigf1mtorpathwayskeletal muscle hypertrophy is regulated via akt-mtor pathway
biocartamtorpathwaymtor signaling pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-165159mTOR signalling
reactomeR-HSA-166208mTORC1-mediated signalling
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-72613Eukaryotic Translation Initiation
reactomeR-HSA-72662Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
reactomeR-HSA-72737Cap-dependent Translation Initiation
reactomeR-HSA-72766Translation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD481Dactolisib1
iGMDRD582MLN 22381
iGMDRD157Ouabain1
iGMDRD310Everolimus1
iGMDRD526KX2-3911
iGMDRD610WYE-3541
iGMDRD871BRD63683
iGMDRD715BRD-K095874291
iGMDRD872BRD71373
iGMDRD256NVP-2311
iGMDRD405PIK-753
iGMDRD321Daporinad1
iGMDRD738PP-2421
iGMDRD798Ceranib-21
iGMDRD123Isoevodiamine1
iGMDRD85Ursolic acid3
iGMDRD441TW 371
iGMDRD294Batimastat1
iGMDRD782DC-45-A23
iGMDRD117Docetaxel1
iGMDRD255SB2250021
iGMDRD260FQI-21
iGMDRD94Narciclasine1
iGMDRD224Necrostatin-11
iGMDRD609BRD-K664538931
iGMDRD473GDC-08791
iGMDRD621BRD-K191035801
iGMDRD428Brivanib1
iGMDRD857BRD-K705115741
iGMDRD151CHM-11
iGMDRD623BRD-K520373521
iGMDRD152179324-69-71
iGMDRD528rigosertib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EIF4EBP1

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