EIF4EBP1
Summary: This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| eukaryotic translation initiation factor 4E binding protein 1 | MIM:602223 | Ensembl:ENSG00000187840 | HGNC:HGNC:3288 | PA27715 | 8p11.23 |
Gene Categories:
TUMOR SUPPRESSORGO terms in EIF4EBP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| BP | IMP | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IEA | GO:0002192 | IRES-dependent translational initiation of linear mRNA |
| BP | IEA | GO:0008286 | insulin receptor signaling pathway |
| BP | IDA | GO:0031929 | TOR signaling |
| BP | IMP | GO:0045931 | positive regulation of mitotic cell cycle |
| BP | IBA | GO:0045947 | negative regulation of translational initiation |
| BP | IDA | GO:0045947 | negative regulation of translational initiation |
| BP | IEA | GO:0071549 | cellular response to dexamethasone stimulus |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008190 | eukaryotic initiation factor 4E binding |
| MF | IDA | GO:0008190 | eukaryotic initiation factor 4E binding |
| MF | IDA | GO:0030371 | translation repressor activity |
Gene expression in normal tissue: EIF4EBP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EIF4EBP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP107 | Translation Factors |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP1471 | Target Of Rapamycin (TOR) Signaling |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2035 | Follicle Stimulating Hormone (FSH) signaling pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP2263 | Androgen Receptor Network in Prostate Cancer |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP244 | Alpha 6 Beta 4 signaling pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP3676 | BDNF-TrkB Signaling |
| wikipathways | WP3844 | PI3K-AKT-mTOR signaling pathway and therapeutic opportunities |
| wikipathways | WP3879 | 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP516 | Hypertrophy Model |
| wikipathways | WP585 | Interferon type I signaling pathways |
| wikipathways | WP673 | ErbB Signaling Pathway |
| smpdb | SMP00682 | Leucine Stimulation on Insulin Signaling |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_Leptin | Leptin |
| pid | insulin_pathway | Insulin Pathway |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | mtor_4pathway | mTOR signaling pathway |
| pid | p38alphabetadownstreampathway | Signaling mediated by p38-alpha and p38-beta |
| kegg | hsa03013 | RNA transport - Homo sapiens (human) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| biocarta | eif4pathway | regulation of eif-4e and p70s6 kinase |
| biocarta | igf1mtorpathway | skeletal muscle hypertrophy is regulated via akt-mtor pathway |
| biocarta | mtorpathway | mtor signaling pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-165159 | mTOR signalling |
| reactome | R-HSA-166208 | mTORC1-mediated signalling |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-72613 | Eukaryotic Translation Initiation |
| reactome | R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| reactome | R-HSA-72737 | Cap-dependent Translation Initiation |
| reactome | R-HSA-72766 | Translation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD582 | MLN 2238 | 1 |
| iGMDRD157 | Ouabain | 1 |
| iGMDRD310 | Everolimus | 1 |
| iGMDRD526 | KX2-391 | 1 |
| iGMDRD610 | WYE-354 | 1 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD715 | BRD-K09587429 | 1 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD256 | NVP-231 | 1 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD321 | Daporinad | 1 |
| iGMDRD738 | PP-242 | 1 |
| iGMDRD798 | Ceranib-2 | 1 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD94 | Narciclasine | 1 |
| iGMDRD224 | Necrostatin-1 | 1 |
| iGMDRD609 | BRD-K66453893 | 1 |
| iGMDRD473 | GDC-0879 | 1 |
| iGMDRD621 | BRD-K19103580 | 1 |
| iGMDRD428 | Brivanib | 1 |
| iGMDRD857 | BRD-K70511574 | 1 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD623 | BRD-K52037352 | 1 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD528 | rigosertib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EIF4EBP1
CLASSFICATION
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