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iGMDRD310

Canonical SMILES: CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OCCO)C)C)O)OC)C)C)C)OC

InChI: InChI=1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1

InChI Key: HKVAMNSJSFKALM-GKUWKFKPSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug targets (TTD)	Drug Type
Everolimus	CHEMBL1908360	6442180	DB01590	Alone	DAP001223	Small Molecule

Drug Class:

Anti-Bacterial Agents Antineoplastic Agents Antineoplastic and Immunomodulating Agents CYP3A Substrates (Sensitive)Cytochrome P-450 CYP3A Substrates Hyperglycemia-Associated Agents Immunologic Factors Immunosuppressive Agents Kinase Inhibitor Lactones Macrocyclic Compounds Macrolides mTOR Inhibitor Immunosuppressant Myelosuppressive Agents Polycyclic Compounds Polyketides Protein Kinase Inhibitors Selective Immunosuppressants Sirolimus

Drug Targets:

MTOR (P42345)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
2475	MTOR	28
2176	FANCC	1
4771	NF2	8
207	AKT1	1
2064	ERBB2	7
7157	TP53	3
2099	ESR1	1
6794	STK11	2
7249	TSC2	17
1978	EIF4EBP1	1
5290	PIK3CA	7
5728	PTEN	11
208	AKT2	1
7248	TSC1	27
6194	RPS6	1
201163	FLCN	4
4893	NRAS	1
4763	NF1	22
3265	HRAS	1
55193	PBRM1	1
1499	CTNNB1	8

Gene in drug-gene network: Network Plot

Models in Everolimus

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.