AKT1

Summary: The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameAKT serine/threonine kinase 1
OMIM IDMIM:164730
Ensembl IDEnsembl:ENSG00000142208
HGNC IDHGNC:HGNC:391
PHARMGKB IDPA24684
Map Location14q32.33

GO terms in AKT1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IMP GO:0000060 protein import into nucleus, translocation
BP IEA GO:0001649 osteoblast differentiation
BP IEA GO:0001893 maternal placenta development
BP IDA GO:0001934 positive regulation of protein phosphorylation
BP IMP GO:0001938 positive regulation of endothelial cell proliferation
BP IEA GO:0005978 glycogen biosynthetic process
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Gene expression in normal tissue: AKT1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 20BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 7SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Cutaneous Melanoma (SKCM) model num: 2SKINtissue: SKIN cancer: Melanoma (MEL) model num: 3HEAD_NECtissue: HEAD_NEC cancer: HEAD_NECK model num: 0HEAD_NECKtissue: HEAD_NECK cancer: Head and Neck Squamous Cell Carcinoma (HNSC) model num: 1HEAD_NECKtissue: HEAD_NECK cancer: Head and Neck Carcinoma, Other (OHNCA) model num: 1UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 1OTHEtissue: OTHE cancer: OTHER model num: 0OTHERtissue: OTHER cancer: Cancer of Unknown Primary (CUP) model num: 9BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Invasive Breast Carcinoma (BRCA) model num: 2BREASTtissue: BREAST cancer: Breast Carcinoma model num: 6SOFT_TISSUtissue: SOFT_TISSU cancer: SOFT_TISSUE model num: 0SOFT_TISSUEtissue: SOFT_TISSUE cancer: Undifferentiated Pleomorphic Sarcoma/Malignant Fibrous Histiocytoma/High-Grade Spindle Cell Sarcoma (MFH) model num: 1OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: Ovarian Cancer model num: 2

Gene-drug pathway distribution

undefined14PI3K/MTOR signaling3IGFR signaling1Chromatin histone acetylation1Cell cycle1

Pathways in AKT1


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Database
Pathway ID
Pathway Des.
biocarta achpathway role of nicotinic acetylcholine receptors in the regulation of apoptosis
biocarta aktpathway akt signaling pathway
biocarta arfpathway tumor suppressor arf inhibits ribosomal biogenesis
biocarta badpathway regulation of bad phosphorylation
biocarta bcellsurvivalpathway b cell survival pathway
biocarta chemicalpathway apoptotic signaling in response to dna damage
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD577 BIX01294 1
iGMDRD596 Vemurafenib 1
iGMDRD119 Temsirolimus 1
iGMDRD839 BRAF inhibitor 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AKT1

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
MUT(AKT1)|AMP(AKT1) gene CTRP undefined PANCAN nutlin-3 sensitivity in vitro
MUT(AKT1)|CNV(AKT1) gene CTRP undefined PANCAN nutlin-3 sensitivity in vitro
MUT(AKT1) gene CTRP undefined PANCAN ML214 unresponsive in vitro
MUT(AKT1)|DEL(AKT1) gene CTRP undefined PANCAN ML214 unresponsive in vitro
MUT(AKT1) gene CTRP undefined PANCAN nutlin-3 sensitivity in vitro
MUT(AKT1) gene CTRP undefined PANCAN GMX-1778 unresponsive in vitro
MUT(AKT1) gene CTRP undefined PANCAN GW-843682X sensitivity in vitro
MUT(AKT1)|AMP(AKT1) gene CTRP undefined PANCAN GMX-1778 unresponsive in vitro
MUT(AKT1)|CNV(AKT1) gene CTRP undefined PANCAN GMX-1778 unresponsive in vitro
MUT(AKT1)|AMP(AKT1) gene CTRP undefined PANCAN ML214 unresponsive in vitro
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