iGMDRD777

Canonical SMILES: CN1C(=C(C=N1)Cl)C2=C(OC(=C2)C(=O)NC(CC3=CC(=C(C=C3)F)F)CN)Cl.Cl

InChI: InChI=1S/C18H16Cl2F2N4O2.ClH/c1-26-16(12(19)8-24-26)11-6-15(28-17(11)20)18(27)25-10(7-23)4-9-2-3-13(21)14(22)5-9;/h2-3,5-6,8,10H,4,7,23H2,1H3,(H,25,27);1H/t10-;/m0./s1

InChI Key: LAPFKCIDRPWAFU-PPHPATTJSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameGSK2141795 (hydrochloride)
Pubchem CID73330400
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Invasive Breast Carcinoma (BRCA) model num: 1SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Melanoma (MEL) model num: 2

Drug-gene pathway enrichments

3reactome: Signal Transduction3reactome: Generic Transcription Pathway3reactome: RNA Polymerase II Transcription3reactome: Gene expression (Transcription)3reactome: PIP3 activates AKT signaling3reactome: Intracellular signaling by second messengers2wikipathways: Somatroph axis (GH) and its relationship to dietary restriction and aging2wikipathways: Ebola Virus Pathway on Host2wikipathways: EGF-EGFR Signaling Pathway2wikipathways: Insulin Signaling

Drug-gene GO enrichments

5CC: cytoplasm5MF: protein serine/threonine kinase activity4CC: cytosol3BP: negative regulation of apoptotic process3CC: plasma membrane3BP: negative regulation of protein kinase B signaling3BP: cellular response to insulin stimulus3BP: peptidyl-serine phosphorylation3CC: nucleoplasm3CC: nucleus

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
207 AKT1 1
5728 PTEN 1
Showing 1 to 2 of 2 rows

Gene in drug-gene network: Network Plot

Models in GSK2141795 (hydrochloride)

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
FUS(AKT3-.) gene 22722202 BREAST Invasive Breast Carcinoma (BRCA) GSK2141795 sensitivity in vivo
SNV(AKT1 E17K) gene 24735930 SKIN Melanoma (MEL) GSK2141795 sensitivity in vivo
DEL(PTEN) gene 24735930 SKIN Melanoma (MEL) GSK2141795 sensitivity in vivo
Showing 1 to 3 of 3 rows

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