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MTOR

Summary: The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namemechanistic target of rapamycin kinase OMIM IDMIM:601231 Ensembl IDEnsembl:ENSG00000198793 HGNC IDHGNC:HGNC:3942 PHARMGKB IDPA28360 Map Location1p36.22

Gene Categories:

CLINICALLY ACTIONABLE TUMOR SUPPRESSOR TRANSCRIPTION FACTOR BINDING PHOSPHATIDYLINOSITOL 3 KINASE KINASE DNA REPAIR SERINE THREONINE KINASE DRUGGABLE GENOME

GO terms in MTOR

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IDA	GO:0001558	regulation of cell growth
BP	IEA	GO:0001933	negative regulation of protein phosphorylation
BP	IDA	GO:0001934	positive regulation of protein phosphorylation
BP	IEA	GO:0001938	positive regulation of endothelial cell proliferation
BP	IEA	GO:0003007	heart morphogenesis
BP	IEA	GO:0003179	heart valve morphogenesis

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Gene expression in normal tissue: MTOR

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MTOR

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Database	Pathway ID	Pathway Des.
wikipathways	WP1403	AMP-activated Protein Kinase (AMPK) Signaling
wikipathways	WP1471	Target Of Rapamycin (TOR) Signaling
wikipathways	WP1544	MicroRNAs in cardiomyocyte hypertrophy
wikipathways	WP1584	Type II diabetes mellitus
wikipathways	WP1982	Sterol Regulatory Element-Binding Proteins (SREBP) signalling
wikipathways	WP1984	Integrated Breast Cancer Pathway

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD119	Temsirolimus	5
iGMDRD353	PD0325901	1
iGMDRD246	NPC26	4
iGMDRD310	Everolimus	28

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MTOR

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.