CTNNB1
Summary: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namecatenin beta 1 OMIM IDMIM:116806 Ensembl IDEnsembl:ENSG00000168036 HGNC IDHGNC:HGNC:2514 PHARMGKB IDPA27013 Map Location3p22.1 | |||||
GO terms in CTNNB1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000922 | spindle pole |
| CC | IDA | GO:0005622 | intracellular |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005667 | transcription factor complex |
| CC | IDA | GO:0005719 | nuclear euchromatin |
Gene expression in normal tissue: CTNNB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CTNNB1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | gsk3pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages |
| biocarta | hespathway | segmentation clock |
| biocarta | pitx2pathway | multi-step regulation of transcription by pitx2 |
| biocarta | tffpathway | trefoil factors initiate mucosal healing |
| biocarta | wntpathway | wnt signaling pathway |
| reactome | R-HSA-109581 | Apoptosis |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CTNNB1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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