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CTNNB1

Summary: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
catenin beta 1	MIM:116806	Ensembl:ENSG00000168036	HGNC:HGNC:2514	PA27013	3p22.1

Gene Categories:

RNA DIRECTED DNA POLYMERASE HISTONE MODIFICATION DRUGGABLE GENOME CLINICALLY ACTIONABLE TUMOR SUPPRESSOR TRANSCRIPTION FACTOR BINDING TRANSCRIPTION FACTOR COMPLEX DRUG RESISTANCE

GO terms in CTNNB1

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IEA	GO:0000922	spindle pole
CC	IDA	GO:0005622	intracellular
CC	IDA	GO:0005634	nucleus
CC	TAS	GO:0005654	nucleoplasm
CC	IDA	GO:0005667	transcription factor complex
CC	IDA	GO:0005719	nuclear euchromatin
CC	IDA	GO:0005737	cytoplasm
CC	IDA	GO:0005813	centrosome
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0005886	plasma membrane
CC	IDA	GO:0005911	cell-cell junction
CC	IDA	GO:0005912	adherens junction
CC	IBA	GO:0005913	cell-cell adherens junction
CC	IDA	GO:0005913	cell-cell adherens junction
CC	IEA	GO:0005916	fascia adherens
CC	IEA	GO:0005923	bicellular tight junction
CC	HDA	GO:0005925	focal adhesion
CC	IDA	GO:0005938	cell cortex
CC	ISS	GO:0016020	membrane
CC	IDA	GO:0016323	basolateral plasma membrane
CC	IDA	GO:0016328	lateral plasma membrane
CC	IBA	GO:0016342	catenin complex
CC	IDA	GO:0016342	catenin complex
CC	IEA	GO:0016600	flotillin complex
CC	IEA	GO:0030018	Z disc
CC	IEA	GO:0030027	lamellipodium
CC	IDA	GO:0030054	cell junction
CC	TAS	GO:0030054	cell junction
CC	IDA	GO:0030877	beta-catenin destruction complex
CC	IEA	GO:0031528	microvillus membrane
CC	IDA	GO:0032991	protein-containing complex
CC	IDA	GO:0032993	protein-DNA complex
CC	IEA	GO:0034750	Scrib-APC-beta-catenin complex
CC	IEA	GO:0045177	apical part of cell
CC	ISS	GO:0045202	synapse
CC	IDA	GO:0048471	perinuclear region of cytoplasm
CC	HDA	GO:0070062	extracellular exosome
CC	IDA	GO:0070369	beta-catenin-TCF7L2 complex
CC	IDA	GO:0071944	cell periphery
CC	IDA	GO:1990907	beta-catenin-TCF complex
CC	IPI	GO:1990907	beta-catenin-TCF complex
CC	NAS	GO:1990909	Wnt signalosome
BP	IEA	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	IEA	GO:0000578	embryonic axis specification
BP	IEA	GO:0000904	cell morphogenesis involved in differentiation
BP	IC	GO:0001569	branching involved in blood vessel morphogenesis
BP	IEA	GO:0001658	branching involved in ureteric bud morphogenesis
BP	IEA	GO:0001701	in utero embryonic development
BP	IEA	GO:0001702	gastrulation with mouth forming second
BP	IEA	GO:0001708	cell fate specification
BP	IEA	GO:0001711	endodermal cell fate commitment
BP	IEA	GO:0001764	neuron migration
BP	TAS	GO:0001837	epithelial to mesenchymal transition
BP	IEA	GO:0001840	neural plate development
BP	ISS	GO:0002052	positive regulation of neuroblast proliferation
BP	IEA	GO:0002053	positive regulation of mesenchymal cell proliferation
BP	IEA	GO:0002089	lens morphogenesis in camera-type eye
BP	IEA	GO:0003266	regulation of secondary heart field cardioblast proliferation
BP	IEA	GO:0003338	metanephros morphogenesis
BP	IEA	GO:0003340	negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
BP	IEA	GO:0006351	transcription, DNA-templated
BP	IMP	GO:0007155	cell adhesion
BP	IEA	GO:0007160	cell-matrix adhesion
BP	TAS	GO:0007223	Wnt signaling pathway, calcium modulating pathway
BP	IEA	GO:0007268	chemical synaptic transmission
BP	IEA	GO:0007398	ectoderm development
BP	IEA	GO:0007403	glial cell fate determination
BP	IDA	GO:0008285	negative regulation of cell proliferation
BP	IEA	GO:0009948	anterior/posterior axis specification
BP	IEA	GO:0009950	dorsal/ventral axis specification
BP	IEA	GO:0009954	proximal/distal pattern formation
BP	IGI	GO:0010718	positive regulation of epithelial to mesenchymal transition
BP	IMP	GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process
BP	TAS	GO:0016055	Wnt signaling pathway
BP	ISS	GO:0016525	negative regulation of angiogenesis
BP	TAS	GO:0019827	stem cell population maintenance
BP	IEA	GO:0021819	layer formation in cerebral cortex
BP	IEA	GO:0022009	central nervous system vasculogenesis
BP	IEA	GO:0030316	osteoclast differentiation
BP	NAS	GO:0030521	androgen receptor signaling pathway
BP	IEA	GO:0030539	male genitalia development
BP	IEA	GO:0030902	hindbrain development
BP	IDA	GO:0030997	regulation of centriole-centriole cohesion
BP	IEA	GO:0031016	pancreas development
BP	IEA	GO:0031069	hair follicle morphogenesis
BP	IEA	GO:0031641	regulation of myelination
BP	IEA	GO:0032212	positive regulation of telomere maintenance via telomerase
BP	IEA	GO:0032331	negative regulation of chondrocyte differentiation
BP	IDA	GO:0032355	response to estradiol
BP	TAS	GO:0032481	positive regulation of type I interferon production
BP	IEA	GO:0033077	T cell differentiation in thymus
BP	IDA	GO:0033234	negative regulation of protein sumoylation
BP	IMP	GO:0034333	adherens junction assembly
BP	IMP	GO:0034394	protein localization to cell surface
BP	IEA	GO:0035050	embryonic heart tube development
BP	IEA	GO:0035112	genitalia morphogenesis
BP	IEA	GO:0035115	embryonic forelimb morphogenesis
BP	IEA	GO:0035116	embryonic hindlimb morphogenesis
BP	TAS	GO:0035315	hair cell differentiation
BP	TAS	GO:0035635	entry of bacterium into host cell
BP	ISS	GO:0036023	embryonic skeletal limb joint morphogenesis
BP	IEA	GO:0042129	regulation of T cell proliferation
BP	IEA	GO:0042475	odontogenesis of dentin-containing tooth
BP	IEP	GO:0042493	response to drug
BP	IEA	GO:0042733	embryonic digit morphogenesis
BP	IDA	GO:0043065	positive regulation of apoptotic process
BP	IEA	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
BP	IEA	GO:0043410	positive regulation of MAPK cascade
BP	IDA	GO:0043525	positive regulation of neuron apoptotic process
BP	IMP	GO:0044334	canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
BP	IMP	GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process
BP	TAS	GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process
BP	IEA	GO:0045453	bone resorption
BP	IEA	GO:0045603	positive regulation of endothelial cell differentiation
BP	IEA	GO:0045669	positive regulation of osteoblast differentiation
BP	IEA	GO:0045671	negative regulation of osteoclast differentiation
BP	IEA	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway
BP	TAS	GO:0045765	regulation of angiogenesis
BP	IMP	GO:0045892	negative regulation of transcription, DNA-templated
BP	IDA	GO:0045893	positive regulation of transcription, DNA-templated
BP	IMP	GO:0045893	positive regulation of transcription, DNA-templated
BP	IBA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IDA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IMP	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	ISS	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	TAS	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	ISS	GO:0045976	negative regulation of mitotic cell cycle, embryonic
BP	IEA	GO:0048096	chromatin-mediated maintenance of transcription
BP	TAS	GO:0048145	regulation of fibroblast proliferation
BP	IEA	GO:0048469	cell maturation
BP	IEA	GO:0048489	synaptic vesicle transport
BP	IEA	GO:0048538	thymus development
BP	IEA	GO:0048599	oocyte development
BP	IEA	GO:0048617	embryonic foregut morphogenesis
BP	IEA	GO:0048643	positive regulation of skeletal muscle tissue development
BP	IMP	GO:0048660	regulation of smooth muscle cell proliferation
BP	IEA	GO:0048715	negative regulation of oligodendrocyte differentiation
BP	TAS	GO:0050767	regulation of neurogenesis
BP	IEA	GO:0050808	synapse organization
BP	IMP	GO:0051091	positive regulation of DNA-binding transcription factor activity
BP	IEA	GO:0051145	smooth muscle cell differentiation
BP	TAS	GO:0051149	positive regulation of muscle cell differentiation
BP	IC	GO:0051571	positive regulation of histone H3-K4 methylation
BP	IEA	GO:0051884	regulation of timing of anagen
BP	IEA	GO:0051973	positive regulation of telomerase activity
BP	IEA	GO:0060066	oviduct development
BP	IDA	GO:0060070	canonical Wnt signaling pathway
BP	IMP	GO:0060070	canonical Wnt signaling pathway
BP	IEA	GO:0060440	trachea formation
BP	IEA	GO:0060441	epithelial tube branching involved in lung morphogenesis
BP	IEA	GO:0060479	lung cell differentiation
BP	IEA	GO:0060484	lung-associated mesenchyme development
BP	IEA	GO:0060492	lung induction
BP	IEA	GO:0060742	epithelial cell differentiation involved in prostate gland development
BP	IEA	GO:0060769	positive regulation of epithelial cell proliferation involved in prostate gland development
BP	IEA	GO:0060789	hair follicle placode formation
BP	IEA	GO:0060916	mesenchymal cell proliferation involved in lung development
BP	IMP	GO:0061154	endothelial tube morphogenesis
BP	IEA	GO:0061198	fungiform papilla formation
BP	ISS	GO:0061324	canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
BP	ISS	GO:0061549	sympathetic ganglion development
BP	IEA	GO:0061550	cranial ganglion development
BP	IMP	GO:0070602	regulation of centromeric sister chromatid cohesion
BP	IMP	GO:0071363	cellular response to growth factor stimulus
BP	IDA	GO:0071681	cellular response to indole-3-methanol
BP	IEA	GO:0072033	renal vesicle formation
BP	IEA	GO:0072053	renal inner medulla development
BP	IEA	GO:0072054	renal outer medulla development
BP	IEA	GO:0072079	nephron tubule formation
BP	ISS	GO:0072182	regulation of nephron tubule epithelial cell differentiation
BP	IDA	GO:0090279	regulation of calcium ion import
BP	IMP	GO:0098609	cell-cell adhesion
BP	IEA	GO:1903204	negative regulation of oxidative stress-induced neuron death
BP	IEA	GO:1904501	positive regulation of chromatin-mediated maintenance of transcription
BP	IEA	GO:1904793	regulation of euchromatin binding
BP	IDA	GO:1904798	positive regulation of core promoter binding
BP	TAS	GO:1904837	beta-catenin-TCF complex assembly
BP	TAS	GO:1904886	beta-catenin destruction complex disassembly
BP	IEA	GO:1904888	cranial skeletal system development
BP	ISS	GO:1904948	midbrain dopaminergic neuron differentiation
BP	IC	GO:1904954	canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
BP	IMP	GO:1990138	neuron projection extension
BP	IEA	GO:1990403	embryonic brain development
BP	IEA	GO:1990791	dorsal root ganglion development
BP	IDA	GO:2000008	regulation of protein localization to cell surface
BP	IEA	GO:2000017	positive regulation of determination of dorsal identity
BP	IC	GO:2000144	positive regulation of DNA-templated transcription, initiation
BP	IEA	GO:2001234	negative regulation of apoptotic signaling pathway
MF	IDA	GO:0001085	RNA polymerase II transcription factor binding
MF	IPI	GO:0001085	RNA polymerase II transcription factor binding
MF	IPI	GO:0001102	RNA polymerase II activating transcription factor binding
MF	ISS	GO:0003682	chromatin binding
MF	IEA	GO:0003700	DNA-binding transcription factor activity
MF	IBA	GO:0003713	transcription coactivator activity
MF	IDA	GO:0003713	transcription coactivator activity
MF	IMP	GO:0003713	transcription coactivator activity
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0008022	protein C-terminus binding
MF	IPI	GO:0008134	transcription factor binding
MF	TAS	GO:0008134	transcription factor binding
MF	IPI	GO:0019899	enzyme binding
MF	IPI	GO:0019900	kinase binding
MF	IEA	GO:0019901	protein kinase binding
MF	IBA	GO:0019903	protein phosphatase binding
MF	IPI	GO:0019903	protein phosphatase binding
MF	IPI	GO:0030331	estrogen receptor binding
MF	IBA	GO:0035257	nuclear hormone receptor binding
MF	IPI	GO:0035257	nuclear hormone receptor binding
MF	TAS	GO:0035257	nuclear hormone receptor binding
MF	IPI	GO:0044325	ion channel binding
MF	IBA	GO:0045294	alpha-catenin binding
MF	IPI	GO:0045294	alpha-catenin binding
MF	HDA	GO:0045296	cadherin binding
MF	IBA	GO:0045296	cadherin binding
MF	IPI	GO:0045296	cadherin binding
MF	IPI	GO:0046332	SMAD binding
MF	IEA	GO:0046982	protein heterodimerization activity
MF	NAS	GO:0050681	androgen receptor binding
MF	IPI	GO:0070411	I-SMAD binding
MF	IEA	GO:0070491	repressing transcription factor binding
MF	IEA	GO:0097718	disordered domain specific binding

Gene expression in normal tissue: CTNNB1

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CTNNB1

Database	Pathway ID	Pathway Des.
biocarta	gsk3pathway	inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages
biocarta	hespathway	segmentation clock
biocarta	pitx2pathway	multi-step regulation of transcription by pitx2
biocarta	tffpathway	trefoil factors initiate mucosal healing
biocarta	wntpathway	wnt signaling pathway
reactome	R-HSA-109581	Apoptosis
reactome	R-HSA-111465	Apoptotic cleavage of cellular proteins
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1500931	Cell-Cell communication
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-1643685	Disease
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA
reactome	R-HSA-194138	Signaling by VEGF
reactome	R-HSA-194315	Signaling by Rho GTPases
reactome	R-HSA-195253	Degradation of beta-catenin by the destruction complex
reactome	R-HSA-195258	RHO GTPase Effectors
reactome	R-HSA-195721	Signaling by WNT
reactome	R-HSA-195721	Signaling by WNT
reactome	R-HSA-196299	Beta-catenin phosphorylation cascade
reactome	R-HSA-201681	TCF dependent signaling in response to WNT
reactome	R-HSA-201681	TCF dependent signaling in response to WNT
reactome	R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex
reactome	R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-2980736	Peptide hormone metabolism
reactome	R-HSA-3134973	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
reactome	R-HSA-351906	Apoptotic cleavage of cell adhesion proteins
reactome	R-HSA-375170	CDO in myogenesis
reactome	R-HSA-375170	CDO in myogenesis
reactome	R-HSA-3769402	Deactivation of the beta-catenin transactivating complex
reactome	R-HSA-381771	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
reactome	R-HSA-3858494	Beta-catenin independent WNT signaling
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-400508	Incretin synthesis, secretion, and inactivation
reactome	R-HSA-4086398	Ca2+ pathway
reactome	R-HSA-418990	Adherens junctions interactions
reactome	R-HSA-421270	Cell-cell junction organization
reactome	R-HSA-4411364	Binding of TCF/LEF:CTNNB1 to target gene promoters
reactome	R-HSA-4420097	VEGFA-VEGFR2 Pathway
reactome	R-HSA-446728	Cell junction organization
reactome	R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane
reactome	R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane
reactome	R-HSA-4791275	Signaling by WNT in cancer
reactome	R-HSA-4839743	phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
reactome	R-HSA-5218920	VEGFR2 mediated vascular permeability
reactome	R-HSA-525793	Myogenesis
reactome	R-HSA-525793	Myogenesis
reactome	R-HSA-5339716	Misspliced GSK3beta mutants stabilize beta-catenin
reactome	R-HSA-5357801	Programmed Cell Death
reactome	R-HSA-5358747	S33 mutants of beta-catenin aren't phosphorylated
reactome	R-HSA-5358749	S37 mutants of beta-catenin aren't phosphorylated
reactome	R-HSA-5358751	S45 mutants of beta-catenin aren't phosphorylated
reactome	R-HSA-5358752	T41 mutants of beta-catenin aren't phosphorylated
reactome	R-HSA-5626467	RHO GTPases activate IQGAPs
reactome	R-HSA-5663202	Diseases of signal transduction
reactome	R-HSA-5663205	Infectious disease
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-74160	Gene expression (Transcription)
reactome	R-HSA-75153	Apoptotic execution phase
reactome	R-HSA-8876384	Listeria monocytogenes entry into host cells
reactome	R-HSA-8876493	InlA-mediated entry of Listeria monocytogenes into host cells
reactome	R-HSA-8878159	Transcriptional regulation by RUNX3
reactome	R-HSA-8951430	RUNX3 regulates WNT signaling
reactome	R-HSA-9006934	Signaling by Receptor Tyrosine Kinases
wikipathways	WP138	Androgen receptor signaling pathway
wikipathways	WP1544	MicroRNAs in cardiomyocyte hypertrophy
wikipathways	WP1591	Heart Development
wikipathways	WP2003	miR-targeted genes in leukocytes - TarBase
wikipathways	WP2004	miR-targeted genes in lymphocytes - TarBase
wikipathways	WP2005	miR-targeted genes in muscle cell - TarBase
wikipathways	WP2036	TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
wikipathways	WP2064	Neural Crest Differentiation
wikipathways	WP2118	Arrhythmogenic Right Ventricular Cardiomyopathy
wikipathways	WP2272	Pathogenic Escherichia coli infection
wikipathways	WP2355	Corticotropin-releasing hormone signaling pathway
wikipathways	WP236	Adipogenesis
wikipathways	WP2363	Gastric Cancer Network 2
wikipathways	WP2380	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathways	WP2572	Primary Focal Segmental Glomerulosclerosis FSGS
wikipathways	WP2804	Hair Follicle Development- Induction (Part 1 of 3)
wikipathways	WP2853	Endoderm Differentiation
wikipathways	WP2858	Ectoderm Differentiation
wikipathways	WP2870	Extracellular vesicle-mediated signaling in recipient cells
wikipathways	WP306	Focal Adhesion
wikipathways	WP3303	Rac1-Pak1-p38-MMP-2 pathway
wikipathways	WP363	Wnt Signaling Pathway
wikipathways	WP3664	Regulation of Wnt-B-catenin Signaling by Small Molecule Compounds
wikipathways	WP3680	Association Between Physico-Chemical Features and Toxicity Associated Pathways
wikipathways	WP3888	VEGFA-VEGFR2 Signaling Pathway
wikipathways	WP3931	ESC Pluripotency Pathways
wikipathways	WP3969	H19 action Rb-E2F1 signaling and CDK-?-catenin activity
wikipathways	WP3971	Role of Osx and miRNAs in tooth development
wikipathways	WP3981	miRNA regulation of prostate cancer signaling pathways
wikipathways	WP399	Wnt Signaling Pathway and Pluripotency
wikipathways	WP4147	PTF1A related regulatory pathway
wikipathways	WP4150	Wnt Signaling in Kidney Disease
wikipathways	WP4155	Endometrial cancer
wikipathways	WP4216	Chromosomal and microsatellite instability in colorectal cancer
wikipathways	WP4239	EMT transition in Colorectal Cancer
wikipathways	WP428	Wnt Signaling Pathway
wikipathways	WP560	TGF-beta Receptor Signaling
wikipathways	WP706	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
wikipathways	WP710	DNA Damage Response (only ATM dependent)
pid	ajdiss_2pathway	Posttranslational regulation of adherens junction stability and dissassembly
pid	ap1_pathway	AP-1 transcription factor network
pid	ar_pathway	Coregulation of Androgen receptor activity
pid	arf6_traffickingpathway	Arf6 trafficking events
pid	betacatenin_deg_pathway	Degradation of beta catenin
pid	betacatenin_nuc_pathway	Regulation of nuclear beta catenin signaling and target gene transcription
pid	cdc42_pathway	CDC42 signaling events
pid	ecadherin_keratinocyte_pathway	E-cadherin signaling in keratinocytes
pid	ecadherin_nascentaj_pathway	E-cadherin signaling in the nascent adherens junction
pid	ecadherin_stabilization_pathway	Stabilization and expansion of the E-cadherin adherens junction
pid	foxopathway	FoxO family signaling
pid	ilk_pathway	Integrin-linked kinase signaling
pid	met_pathway	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pid	ncadherinpathway	N-cadherin signaling events
pid	nectin_pathway	Nectin adhesion pathway
pid	ps1pathway	Presenilin action in Notch and Wnt signaling
pid	rac1_pathway	RAC1 signaling pathway
pid	tgfbrpathway	TGF-beta receptor signaling
pid	vegfr1_2_pathway	Signaling events mediated by VEGFR1 and VEGFR2
pid	wnt_canonical_pathway	Canonical Wnt signaling pathway
kegg	hsa04015	Rap1 signaling pathway - Homo sapiens (human)
kegg	hsa04310	Wnt signaling pathway - Homo sapiens (human)
kegg	hsa04390	Hippo signaling pathway - Homo sapiens (human)
kegg	hsa04510	Focal adhesion - Homo sapiens (human)
kegg	hsa04520	Adherens junction - Homo sapiens (human)
kegg	hsa04550	Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegg	hsa04670	Leukocyte transendothelial migration - Homo sapiens (human)
kegg	hsa04916	Melanogenesis - Homo sapiens (human)
kegg	hsa04919	Thyroid hormone signaling pathway - Homo sapiens (human)
kegg	hsa04934	Cushing,s syndrome - Homo sapiens (human)
kegg	hsa05100	Bacterial invasion of epithelial cells - Homo sapiens (human)
kegg	hsa05130	Pathogenic Escherichia coli infection - Homo sapiens (human)
kegg	hsa05165	Human papillomavirus infection - Homo sapiens (human)
kegg	hsa05166	HTLV-I infection - Homo sapiens (human)
kegg	hsa05167	Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05205	Proteoglycans in cancer - Homo sapiens (human)
kegg	hsa05210	Colorectal cancer - Homo sapiens (human)
kegg	hsa05213	Endometrial cancer - Homo sapiens (human)
kegg	hsa05215	Prostate cancer - Homo sapiens (human)
kegg	hsa05216	Thyroid cancer - Homo sapiens (human)
kegg	hsa05217	Basal cell carcinoma - Homo sapiens (human)
kegg	hsa05224	Breast cancer - Homo sapiens (human)
kegg	hsa05225	Hepatocellular carcinoma - Homo sapiens (human)
kegg	hsa05226	Gastric cancer - Homo sapiens (human)
kegg	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)
kegg	hsa05418	Fluid shear stress and atherosclerosis - Homo sapiens (human)
pharmgkb	PA152241951	Celecoxib Pathway, Pharmacodynamics
netpath	Pathway_AndrogenReceptor	AndrogenReceptor
netpath	Pathway_BCR	BCR
netpath	Pathway_Fibroblast__growth__factor-1	Fibroblast growth factor-1
netpath	Pathway_Gastrin	Gastrin
netpath	Pathway_Hedgehog	Hedgehog
netpath	Pathway_IL5	IL5
netpath	Pathway_TCR	TCR
netpath	Pathway_TGF_beta_Receptor	TGF_beta_Receptor
netpath	Pathway_Wnt	Wnt

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD103	SN-38	4
iGMDRD28	Letrozole	8
iGMDRD137	Indisulam	4
iGMDRD158	NSC141540	5
iGMDRD105	Triptolide	4
iGMDRD705	Nakiterpiosin	3
iGMDRD329	Merck60	2
iGMDRD366	PI-103	3
iGMDRD286	Nsc 632839	5
iGMDRD367	Ro 28-1675	1
iGMDRD245	FH535	2
iGMDRD552	AZD-1775	4
iGMDRD263	AACOCF3	4
iGMDRD719	IOX2	1
iGMDRD564	GSK-650394	1
iGMDRD405	PIK-75	1
iGMDRD79	Gemcitabine	3
iGMDRD150	RITA	3
iGMDRD352	PD-0325901	1
iGMDRD314	Tanespimycin	8
iGMDRD237	ABT-751	1
iGMDRD123	Isoevodiamine	3
iGMDRD260	FQI-2	4
iGMDRD187	BRD9876	3
iGMDRD284	Palbociclib	1
iGMDRD133	Lapatinib	1
iGMDRD188	Piperlongumine	8
iGMDRD399	Selumetinib	2
iGMDRD74	Idarubicin	7
iGMDRD64	Parbendazole	2
iGMDRD190	Nilotinib	1
iGMDRD420	Leucascandrolide A	3
iGMDRD151	CHM-1	4
iGMDRD409	Saracatinib	1
iGMDRD748	PHA-665752	1
iGMDRD61	Kinetin riboside	7
iGMDRD470	Trametinib	1
iGMDRD466	Chaetocin	4
iGMDRD310	Everolimus	8
iGMDRD68	Paclitaxel	1
iGMDRD459	RO-3306	1
iGMDRD231	Importazole	3
iGMDRD434	BMS-536924	1
iGMDRD414	MST-312	3
iGMDRD872	BRD7137	1
iGMDRD42	Vorinostat	1
iGMDRD886	Compound 1541A	1
iGMDRD300	Tozasertib	4
iGMDRD505	Pevonedistat	4
iGMDRD246	NPC26	4
iGMDRD512	nutlin 3	5
iGMDRD84	Lovastatin acid	1
iGMDRD456	Crizotinib	1
iGMDRD125	BIRB-796	1
iGMDRD116	CD437	4
iGMDRD424	Tamatinib	4
iGMDRD345	Compound 10b [PMID: 11504634]	2
iGMDRD351	GW843682X	4
iGMDRD536	PLX-4720	1
iGMDRD211	(1S,3R)-RSL3	3
iGMDRD1014	Tankyrase inhibitor	2
iGMDRD177	Teniposide	4
iGMDRD802	4-methylfasudil	2
iGMDRD255	SB225002	1
iGMDRD134	Sorafenib	1
iGMDRD491	TAE-684	1
iGMDRD440	Nutlin-3A	4
iGMDRD441	TW 37	6
iGMDRD309	17AAG	1
iGMDRD782	DC-45-A2	2
iGMDRD562	Navitoclax	5
iGMDRD100	Zebularine	1
iGMDRD887	Compound 23 citrate	3
iGMDRD131	Erlotinib	2
iGMDRD387	CHIR-99021	1
iGMDRD136	Nutlin-3	1
iGMDRD494	Neopeltolide	10
iGMDRD142	NSC74859	1
iGMDRD446	LY 2183240	2
iGMDRD71	Sparfosic acid	3
iGMDRD634	SCHEMBL2608041	6
iGMDRD401	Afatinib	1
iGMDRD280	CYTOCHALASIN B	8

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CTNNB1

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.