iGMDRD28

Canonical SMILES: C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3

InChI: InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H

InChI Key: HPJKCIUCZWXJDR-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
KEGG Drug ID
DRUGBANK ID
Drug Status
Drug targets (TTD)
Drug Type
Standard NameLetrozole
CHEMBLCHEMBL1444
Pubchem CID3902
KEGG Drug IDD00964
DRUGBANK IDDB01006
Drug StatusAlone
Drug targets (TTD)DAP000626
Drug TypeSmall Molecule


Drug Targets:

CYP19A1 (P11511)


Drug-model tissue-cancer distribution: Bubble Plot

UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 8BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Invasive Breast Carcinoma (BRCA) model num: 1BREASTtissue: BREAST cancer: Breast Carcinoma model num: 4

Drug-gene pathway enrichments

5reactome: Generic Transcription Pathway5reactome: Gene expression (Transcription)5reactome: Signal Transduction5reactome: RNA Polymerase II Transcription4kegg: Pathways in cancer - Homo sapiens (human)4reactome: Signaling by Receptor Tyrosine Kinases3reactome: Metabolism of proteins3wikipathways: miR-targeted genes in muscle cell - TarBase3wikipathways: DNA Damage Response (only ATM dependent)3pid: AP-1 transcription factor network

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
2064 ERBB2 1
1029 CDKN2A 3
2099 ESR1 2
1499 CTNNB1 8
Showing 1 to 4 of 4 rows

Gene in drug-gene network: Network Plot

Models in Letrozole

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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