iGMDRD284
| Standard Name | CHEMBL | Pubchem CID | DRUGBANK ID | Drug Status | Drug Type |
|---|---|---|---|---|---|
| Palbociclib | CHEMBL2364621 CHEMBL189963 | 5330290 | DB09073 | Alone | Small Molecule |
Drug Class:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsCyclin-Dependent Kinases, antagonists & inhibitorsCytochrome P-450 CYP3A InhibitorsCytochrome P-450 CYP3A4 InhibitorsCytochrome P-450 CYP3A4 Inhibitors (weak)Cytochrome P-450 Enzyme InhibitorsEnzyme InhibitorsHeterocyclic CompoundsHeterocyclic Compounds, 1-RingImmunosuppressive AgentsKinase InhibitorMyelosuppressive AgentsProtein Kinase InhibitorsDrug Pathways:
Cell cycleDrug-model tissue-cancer distribution: Bubble Plot
Drug-gene pathway enrichments
Drug-gene GO enrichments
Drug-Gene: Aster Plot
| Gene ID | Gene Name | Model Num. |
|---|---|---|
| 3725 | JUN | 1 |
| 54521 | WDR44 | 1 |
| 7172 | TPMT | 2 |
| 2956 | MSH6 | 1 |
| 106480631 | RNU6-1026P | 2 |
| 103 | ADAR | 1 |
| 6913 | TBX15 | 1 |
| 105372352 | LOC105372352 | 1 |
| 3845 | KRAS | 4 |
| 344595 | DUBR | 1 |
| 100289092 | ATP2A1-AS1 | 1 |
| 5295 | PIK3R1 | 1 |
| 100873543 | RNA5SP290 | 2 |
| 6517 | SLC2A4 | 1 |
| 347404 | LANCL3 | 1 |
| 57731 | SPTBN4 | 1 |
| 1993 | ELAVL2 | 1 |
| 3431 | SP110 | 1 |
| 6597 | SMARCA4 | 1 |
| 23107 | MRPS27 | 1 |
| 114088 | TRIM9 | 1 |
| 84626 | KRBA1 | 1 |
| 4771 | NF2 | 1 |
| 6598 | SMARCB1 | 1 |
| 100533662 | STK25P1 | 2 |
| 10160 | FARP1 | 1 |
| 134957 | STXBP5 | 1 |
| 6574 | SLC20A1 | 1 |
| 642996 | NFE2L3P1 | 2 |
| 8242 | KDM5C | 1 |
| 400120 | SERTM1 | 1 |
| 65055 | REEP1 | 1 |
| 100130983 | RPL26P28 | 1 |
| 4851 | NOTCH1 | 2 |
| 55294 | FBXW7 | 1 |
| 1021 | CDK6 | 2 |
| 4610 | MYCL | 1 |
| 158747 | MOSPD2 | 1 |
| 10301 | DLEU1 | 1 |
| 122011 | CSNK1A1L | 2 |
| 4300 | MLLT3 | 1 |
| 51343 | FZR1 | 1 |
| 51742 | ARID4B | 1 |
| 695 | BTK | 1 |
| 1033 | CDKN3 | 1 |
| 401562 | LCNL1 | 1 |
| 3730 | ANOS1 | 1 |
| 238 | ALK | 1 |
| 54842 | MFSD6 | 1 |
| 7428 | VHL | 1 |
| 57528 | KCTD16 | 1 |
| 2064 | ERBB2 | 3 |
| 84440 | RAB11FIP4 | 1 |
| 6416 | MAP2K4 | 1 |
| 92346 | C1orf105 | 1 |
| 90655 | TGIF2LY | 1 |
| 51144 | HSD17B12 | 1 |
| 5798 | PTPRN | 1 |
| 2778 | GNAS | 1 |
| 55303 | GIMAP4 | 1 |
| 6704 | SPRR2E | 1 |
| 898 | CCNE1 | 1 |
| 1029 | CDKN2A | 14 |
| 145837 | DRAIC | 1 |
| 861 | RUNX1 | 1 |
| 6000 | RGS7 | 1 |
| 64223 | MLST8 | 1 |
| 7157 | TP53 | 1 |
| 2099 | ESR1 | 2 |
| 3673 | ITGA2 | 1 |
| 84886 | C1orf198 | 1 |
| 6794 | STK11 | 1 |
| 3791 | KDR | 1 |
| 4292 | MLH1 | 1 |
| 106481037 | RN7SL416P | 2 |
| 1019 | CDK4 | 7 |
| 200162 | SPAG17 | 1 |
| 94015 | TTYH2 | 1 |
| 85439 | STON2 | 1 |
| 51198 | CDKN2A-DT | 2 |
| 4111 | MAGEA12 | 1 |
| 3204 | HOXA7 | 1 |
| 4089 | SMAD4 | 1 |
| 255426 | RASGEF1C | 1 |
| 100616326 | MIR4636 | 2 |
| 79645 | EFCAB1 | 1 |
| 1028 | CDKN1C | 1 |
| 3417 | IDH1 | 1 |
| 8731 | RNMT | 1 |
| 5290 | PIK3CA | 2 |
| 203245 | NAIF1 | 1 |
| 6391 | SDHC | 1 |
| 1956 | EGFR | 1 |
| 4609 | MYC | 2 |
| 101927720 | ZNF793-AS1 | 1 |
| 90113 | VWA5B2 | 1 |
| 1031 | CDKN2C | 1 |
| 894 | CCND2 | 1 |
| 896 | CCND3 | 1 |
| 5156 | PDGFRA | 1 |
| 23265 | EXOC7 | 1 |
| 9988 | DMTF1 | 1 |
| 8193 | DPF1 | 1 |
| 18 | ABAT | 1 |
| 79605 | PGBD5 | 1 |
| 673 | BRAF | 1 |
| 51400 | PPME1 | 2 |
| 6175 | RPLP0 | 1 |
| 1938 | EEF2 | 1 |
| 2113 | ETS1 | 1 |
| 3964 | LGALS8 | 1 |
| 81553 | FAM49A | 1 |
| 100147767 | RNU7-19P | 1 |
| 10752 | CHL1 | 1 |
| 5728 | PTEN | 1 |
| 208 | AKT2 | 1 |
| 64344 | HIF3A | 1 |
| 6252 | RTN1 | 1 |
| 109729118 | MTCYBP41 | 2 |
| 93556 | EGFEM1P | 1 |
| 100506555 | NECTIN3-AS1 | 1 |
| 70 | ACTC1 | 1 |
| 9711 | RUBCN | 1 |
| 442167 | ASS1P1 | 1 |
| 143458 | LDLRAD3 | 1 |
| 120114 | FAT3 | 1 |
| 392313 | OR2S1P | 1 |
| 157869 | SBSPON | 1 |
| 199870 | FAM76A | 1 |
| 55852 | TEX2 | 1 |
| 4741 | NEFM | 1 |
| 4810 | NHS | 1 |
| 55026 | TMEM255A | 1 |
| 23500 | DAAM2 | 1 |
| 7780 | SLC30A2 | 1 |
| 106481384 | RNU6-642P | 1 |
| 649446 | DLGAP1-AS1 | 1 |
| 54965 | PIGX | 1 |
| 252995 | FNDC5 | 1 |
| 3717 | JAK2 | 1 |
| 29841 | GRHL1 | 1 |
| 1030 | CDKN2B | 2 |
| 65267 | WNK3 | 1 |
| 100873337 | MTND1P14 | 1 |
| 126669 | SHE | 1 |
| 391190 | OR2L8 | 2 |
| 5925 | RB1 | 13 |
| 4893 | NRAS | 2 |
| 6588 | SLN | 1 |
| 9892 | SNAP91 | 1 |
| 7403 | KDM6A | 1 |
| 142 | PARP1 | 1 |
| 154661 | RUNDC3B | 1 |
| 595 | CCND1 | 6 |
| 4763 | NF1 | 1 |
| 4613 | MYCN | 1 |
| 9644 | SH3PXD2A | 1 |
| 390940 | PINLYP | 1 |
| 5884 | RAD17 | 1 |
| 79537 | OR7E90P | 2 |
| 80274 | SCUBE1 | 1 |
| 3265 | HRAS | 1 |
| 4193 | MDM2 | 1 |
| 1499 | CTNNB1 | 1 |
| 5624 | PROC | 2 |
Gene in drug-gene network: Network Plot
Models in Palbociclib
CLASSFICATION
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