OR2L8
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
GO terms in OR2L8
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ND | GO:0003674 | molecular_function |
| MF | IEA | GO:0004930 | G-protein coupled receptor activity |
| MF | IBA | GO:0004984 | olfactory receptor activity |
| BP | ND | GO:0008150 | biological_process |
| BP | IEA | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell |
| CC | TAS | GO:0005886 | plasma membrane |
Gene expression in normal tissue: OR2L8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in OR2L8
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04740 | Olfactory transduction - Homo sapiens (human) |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-381753 | Olfactory Signaling Pathway |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418555 | G alpha (s) signalling events |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD284 | Palbociclib | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in OR2L8
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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