CCNE1
Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin E1 | MIM:123837 | Ensembl:ENSG00000105173 | HGNC:HGNC:1589 | PA96 | 19q12 |
GO terms in CCNE1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0003713 | transcription coactivator activity |
| MF | IBA | GO:0004672 | protein kinase activity |
| MF | TAS | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity |
| MF | IEA | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity |
| MF | IBA | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | NAS | GO:0050681 | androgen receptor binding |
| CC | IBA | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005813 | centrosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0097134 | cyclin E1-CDK2 complex |
| CC | IEA | GO:0097134 | cyclin E1-CDK2 complex |
| BP | IBA | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | NAS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | TAS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | TAS | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0000278 | mitotic cell cycle |
| BP | IEA | GO:0000723 | telomere maintenance |
| BP | IEA | GO:0006270 | DNA replication initiation |
| BP | IMP | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0007088 | regulation of mitotic nuclear division |
| BP | IBA | GO:0007129 | synapsis |
| BP | IEA | GO:0007129 | synapsis |
| BP | IBA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | NAS | GO:0030521 | androgen receptor signaling pathway |
| BP | IBA | GO:0045787 | positive regulation of cell cycle |
| BP | IEA | GO:0045859 | regulation of protein kinase activity |
| BP | NAS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0051301 | cell division |
| BP | IEA | GO:0051726 | regulation of cell cycle |
| BP | IEA | GO:1903827 | regulation of cellular protein localization |
Gene expression in normal tissue: CCNE1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CCNE1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | bard1pathway | BARD1 signaling events |
| pid | e2f_pathway | E2F transcription factor network |
| pid | foxm1pathway | FOXM1 transcription factor network |
| pid | mtor_4pathway | mTOR signaling pathway |
| pid | plk3_pathway | PLK3 signaling events |
| pid | prlsignalingeventspathway | Signaling events mediated by PRL |
| pid | rb_1pathway | Regulation of retinoblastoma protein |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_RAGE | RAGE |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP1545 | miRNAs involved in DNA damage response |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP1858 | Mitotic G1-G1-S phases |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2359 | Parkin-Ubiquitin Proteasomal System pathway |
| wikipathways | WP2371 | Parkinsons Disease Pathway |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP2516 | ATM Signaling Pathway |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP45 | G1 to S cell cycle control |
| wikipathways | WP53 | ID signaling pathway |
| wikipathways | WP707 | DNA Damage Response |
| reactome | R-HSA-1538133 | G0 and Early G1 |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-390466 | Chaperonin-mediated protein folding |
| reactome | R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis |
| reactome | R-HSA-391251 | Protein folding |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-539107 | Activation of E2F1 target genes at G1/S |
| reactome | R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes |
| reactome | R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest |
| reactome | R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 |
| reactome | R-HSA-69052 | Switching of origins to a post-replicative state |
| reactome | R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes |
| reactome | R-HSA-69202 | Cyclin E associated events during G1/S transition |
| reactome | R-HSA-69205 | G1/S-Specific Transcription |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69239 | Synthesis of DNA |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69306 | DNA Replication |
| reactome | R-HSA-69563 | p53-Dependent G1 DNA Damage Response |
| reactome | R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint |
| reactome | R-HSA-69615 | G1/S DNA Damage Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8848021 | Signaling by PTK6 |
| reactome | R-HSA-8849470 | PTK6 Regulates Cell Cycle |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases |
| biocarta | cellcyclepathway | cyclins and cell cycle regulation |
| biocarta | fbw7pathway | cyclin e destruction pathway |
| biocarta | g1pathway | cell cycle: g1/s check point |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| biocarta | mcmpathway | cdk regulation of dna replication |
| biocarta | p27pathway | regulation of p27 phosphorylation during cell cycle progression |
| biocarta | p53pathway | p53 signaling pathway |
| biocarta | raccycdpathway | influence of ras and rho proteins on g1 to s transition |
| biocarta | skp2e2fpathway | e2f1 destruction pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD105 | Triptolide | 5 |
| iGMDRD705 | Nakiterpiosin | 5 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD481 | Dactolisib | 8 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD103 | SN-38 | 1 |
| iGMDRD886 | Compound 1541A | 5 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD300 | Tozasertib | 7 |
| iGMDRD872 | BRD7137 | 4 |
| iGMDRD414 | MST-312 | 8 |
| iGMDRD664 | Dinaciclib | 1 |
| iGMDRD119 | Temsirolimus | 1 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD584 | VER 155008 | 3 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD435 | BI-2536 | 5 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD219 | Bax channel blocker | 2 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 1 |
| iGMDRD284 | Palbociclib | 1 |
| iGMDRD885 | Compound 110 | 8 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD270 | Ciclosporin | 1 |
| iGMDRD109 | Gefitinib | 1 |
| iGMDRD60 | Quinoclamine | 1 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD399 | Selumetinib | 5 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD398 | Sepantronium | 1 |
| iGMDRD506 | Fedratinib | 7 |
| iGMDRD692 | SB590885 | 1 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD772 | BRD4770 | 1 |
| iGMDRD420 | Leucascandrolide A | 6 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD394 | BX-795 | 4 |
| iGMDRD470 | Trametinib | 1 |
| iGMDRD235 | SNS-032 | 1 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD359 | OSW-1 | 6 |
| iGMDRD686 | PF4708671 | 1 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD875 | CDK2 inhibitor | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CCNE1
CLASSFICATION
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