CCNE1


Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cyclin E1MIM:123837Ensembl:ENSG00000105173HGNC:HGNC:1589PA9619q12

GO terms in CCNE1


Term TypeEvidence TypeGO Term IDGO Des.
MFNASGO:0003713transcription coactivator activity
MFIBAGO:0004672protein kinase activity
MFTASGO:0004693cyclin-dependent protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIBAGO:0016538cyclin-dependent protein serine/threonine kinase regulator activity
MFIEAGO:0016538cyclin-dependent protein serine/threonine kinase regulator activity
MFIBAGO:0019901protein kinase binding
MFIEAGO:0019901protein kinase binding
MFNASGO:0050681androgen receptor binding
CCIBAGO:0000307cyclin-dependent protein kinase holoenzyme complex
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIBAGO:0005813centrosome
CCTASGO:0005829cytosol
CCIBAGO:0097134cyclin E1-CDK2 complex
CCIEAGO:0097134cyclin E1-CDK2 complex
BPIBAGO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity
BPNASGO:0000082G1/S transition of mitotic cell cycle
BPTASGO:0000082G1/S transition of mitotic cell cycle
BPTASGO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIBAGO:0000278mitotic cell cycle
BPIEAGO:0000723telomere maintenance
BPIEAGO:0006270DNA replication initiation
BPIMPGO:0006468protein phosphorylation
BPIBAGO:0007088regulation of mitotic nuclear division
BPIBAGO:0007129synapsis
BPIEAGO:0007129synapsis
BPIBAGO:0008284positive regulation of cell proliferation
BPIEAGO:0016055Wnt signaling pathway
BPNASGO:0030521androgen receptor signaling pathway
BPIBAGO:0045787positive regulation of cell cycle
BPIEAGO:0045859regulation of protein kinase activity
BPNASGO:0045893positive regulation of transcription, DNA-templated
BPIEAGO:0051301cell division
BPIEAGO:0051726regulation of cell cycle
BPIEAGO:1903827regulation of cellular protein localization

Gene expression in normal tissue: CCNE1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CCNE1


DatabasePathway IDPathway Des.
pidbard1pathwayBARD1 signaling events
pide2f_pathwayE2F transcription factor network
pidfoxm1pathwayFOXM1 transcription factor network
pidmtor_4pathwaymTOR signaling pathway
pidplk3_pathwayPLK3 signaling events
pidprlsignalingeventspathwaySignaling events mediated by PRL
pidrb_1pathwayRegulation of retinoblastoma protein
netpathPathway_AndrogenReceptorAndrogenReceptor
netpathPathway_IL2IL2
netpathPathway_RAGERAGE
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04114Oocyte meiosis - Homo sapiens (human)
kegghsa04115p53 signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP1530miRNA Regulation of DNA Damage Response
wikipathwaysWP1545miRNAs involved in DNA damage response
wikipathwaysWP179Cell Cycle
wikipathwaysWP1858Mitotic G1-G1-S phases
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2359Parkin-Ubiquitin Proteasomal System pathway
wikipathwaysWP2371Parkinsons Disease Pathway
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP2516ATM Signaling Pathway
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP45G1 to S cell cycle control
wikipathwaysWP53ID signaling pathway
wikipathwaysWP707DNA Damage Response
reactomeR-HSA-1538133G0 and Early G1
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2559586DNA Damage/Telomere Stress Induced Senescence
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-390466Chaperonin-mediated protein folding
reactomeR-HSA-390471Association of TriC/CCT with target proteins during biosynthesis
reactomeR-HSA-391251Protein folding
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-539107Activation of E2F1 target genes at G1/S
reactomeR-HSA-6791312TP53 Regulates Transcription of Cell Cycle Genes
reactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
reactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6
reactomeR-HSA-69052Switching of origins to a post-replicative state
reactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
reactomeR-HSA-69202Cyclin E associated events during G1/S transition
reactomeR-HSA-69205G1/S-Specific Transcription
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69239Synthesis of DNA
reactomeR-HSA-69242S Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69306DNA Replication
reactomeR-HSA-69563p53-Dependent G1 DNA Damage Response
reactomeR-HSA-69580p53-Dependent G1/S DNA damage checkpoint
reactomeR-HSA-69615G1/S DNA Damage Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entry
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8848021Signaling by PTK6
reactomeR-HSA-8849470PTK6 Regulates Cell Cycle
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-9006927Signaling by Non-Receptor Tyrosine Kinases
biocartacellcyclepathwaycyclins and cell cycle regulation
biocartafbw7pathwaycyclin e destruction pathway
biocartag1pathwaycell cycle: g1/s check point
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
biocartamcmpathwaycdk regulation of dna replication
biocartap27pathwayregulation of p27 phosphorylation during cell cycle progression
biocartap53pathwayp53 signaling pathway
biocartaraccycdpathwayinfluence of ras and rho proteins on g1 to s transition
biocartaskp2e2fpathwaye2f1 destruction pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD105Triptolide5
iGMDRD705Nakiterpiosin5
iGMDRD267Oligomycin A3
iGMDRD481Dactolisib8
iGMDRD121GMX17781
iGMDRD158NSC1415402
iGMDRD103SN-381
iGMDRD886Compound 1541A5
iGMDRD505Pevonedistat3
iGMDRD300Tozasertib7
iGMDRD872BRD71374
iGMDRD414MST-3128
iGMDRD664Dinaciclib1
iGMDRD119Temsirolimus1
iGMDRD871BRD63682
iGMDRD366PI-1032
iGMDRD329Merck602
iGMDRD345Compound 10b [PMID: 11504634]3
iGMDRD560MK-22061
iGMDRD523Cyanoquinoline, 113
iGMDRD512nutlin 32
iGMDRD584VER 1550083
iGMDRD177Teniposide3
iGMDRD435BI-25365
iGMDRD237ABT-7512
iGMDRD219Bax channel blocker2
iGMDRD314Tanespimycin1
iGMDRD57Chloropentafluorobenzene1
iGMDRD284Palbociclib1
iGMDRD885Compound 1108
iGMDRD318PAC-11
iGMDRD270Ciclosporin1
iGMDRD109Gefitinib1
iGMDRD60Quinoclamine1
iGMDRD356PNU-746543
iGMDRD887Compound 23 citrate3
iGMDRD399Selumetinib5
iGMDRD188Piperlongumine2
iGMDRD398Sepantronium1
iGMDRD506Fedratinib7
iGMDRD692SB5908851
iGMDRD144NSC953973
iGMDRD781Sirolimus4
iGMDRD494Neopeltolide2
iGMDRD126Tipifarnib3
iGMDRD1008SR-II-138A3
iGMDRD772BRD47701
iGMDRD420Leucascandrolide A6
iGMDRD466Chaetocin1
iGMDRD280CYTOCHALASIN B1
iGMDRD394BX-7954
iGMDRD470Trametinib1
iGMDRD235SNS-0321
iGMDRD634SCHEMBL26080412
iGMDRD359OSW-16
iGMDRD686PF47086711
iGMDRD201SKI II1
iGMDRD875CDK2 inhibitor2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CCNE1

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