iGMDRD692

Canonical SMILES: CN(C)CCOC1=CC=C(C=C1)C2=NC(=C3C=CC4=C(CCC4=C3)N=O)C(=C5C=CNC=C5)N2

InChI: InChI=1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5,7-9,11-14,17,28H,6,10,15-16H2,1-2H3,(H,29,30)

InChI Key: DPCXEUSDRQOOGZ-UHFFFAOYSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameSB590885
Pubchem CID53240000
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

BRAF

Drug Pathways:

ERK MAPK signaling

Drug-model tissue-cancer distribution: Bubble Plot

OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 1OVARYtissue: OVARY cancer: Ovarian Cancer model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 7BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 1BOWELtissue: BOWEL cancer: Colorectal Adenocarcinoma (COADREAD) model num: 1UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: undefined model num: 1SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Cutaneous Melanoma (SKCM) model num: 3LYMPtissue: LYMP cancer: LYMPH model num: 0LYMPHtissue: LYMPH cancer: Diffuse Large B-Cell Lymphoma (DLBCL) model num: 1HEAD_NECtissue: HEAD_NEC cancer: HEAD_NECK model num: 0HEAD_NECKtissue: HEAD_NECK cancer: Head and Neck Squamous Cell Carcinoma (HNSC) model num: 1BONtissue: BON cancer: BONE model num: 0BONEtissue: BONE cancer: Acute Myeloid Leukemia (AML) model num: 1

Drug-gene pathway enrichments

11reactome: Signal Transduction8reactome: Generic Transcription Pathway8reactome: Gene expression (Transcription)8reactome: RNA Polymerase II Transcription7kegg: Pathways in cancer - Homo sapiens (human)6kegg: MicroRNAs in cancer - Homo sapiens (human)6reactome: Diseases of signal transduction6reactome: Disease6reactome: Signaling by Receptor Tyrosine Kinases6kegg: Hepatocellular carcinoma - Homo sapiens (human)

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
3845 KRAS 1
8289 ARID1A 1
8266 UBL4A 1
1387 CREBBP 1
Showing 1 to 4 of 11 rows rows per page

Gene in drug-gene network: Network Plot

Models in SB590885

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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