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TIGAR

Summary: This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
TP53 induced glycolysis regulatory phosphatase	MIM:610775	Ensembl:ENSG00000078237	HGNC:HGNC:1185	PA25506	12p13.32

Gene Categories:

DNA REPAIR KINASE

GO terms in TIGAR

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005622	intracellular
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005737	cytoplasm
CC	IDA	GO:0005741	mitochondrial outer membrane
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
BP	ISS	GO:0002931	response to ischemia
BP	IDA	GO:0006003	fructose 2,6-bisphosphate metabolic process
BP	IEA	GO:0006914	autophagy
BP	IEA	GO:0006915	apoptotic process
BP	IDA	GO:0006974	cellular response to DNA damage stimulus
BP	IEA	GO:0009410	response to xenobiotic stimulus
BP	IEA	GO:0010332	response to gamma radiation
BP	IEA	GO:0010666	positive regulation of cardiac muscle cell apoptotic process
BP	IEA	GO:0016311	dephosphorylation
BP	IDA	GO:0030388	fructose 1,6-bisphosphate metabolic process
BP	IDA	GO:0043069	negative regulation of programmed cell death
BP	IMP	GO:0043456	regulation of pentose-phosphate shunt
BP	IMP	GO:0045739	positive regulation of DNA repair
BP	IEA	GO:0045820	negative regulation of glycolytic process
BP	IEA	GO:0060576	intestinal epithelial cell development
BP	IDA	GO:0071279	cellular response to cobalt ion
BP	IDA	GO:0071456	cellular response to hypoxia
BP	IEA	GO:1901215	negative regulation of neuron death
BP	IEA	GO:1901525	negative regulation of mitophagy
BP	IMP	GO:1902153	regulation of response to DNA damage checkpoint signaling
BP	IDA	GO:1903301	positive regulation of hexokinase activity
BP	IEA	GO:1904024	negative regulation of glucose catabolic process to lactate via pyruvate
BP	IEA	GO:2000378	negative regulation of reactive oxygen species metabolic process
MF	IDA	GO:0004083	bisphosphoglycerate 2-phosphatase activity
MF	EXP	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity
MF	IDA	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity
MF	IPI	GO:0005515	protein binding

Gene expression in normal tissue: TIGAR

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TIGAR

Database	Pathway ID	Pathway Des.
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-3700989	Transcriptional Regulation by TP53
reactome	R-HSA-5628897	TP53 Regulates Metabolic Genes
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-74160	Gene expression (Transcription)
kegg	hsa00051	Fructose and mannose metabolism - Homo sapiens (human)
kegg	hsa05230	Central carbon metabolism in cancer - Homo sapiens (human)
pid	p53downstreampathway	Direct p53 effectors
humancyc	PWY66-423	fructose 2,6-bisphosphate synthesis
wikipathways	WP3349	TP53 Regulates Metabolic Genes

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD692	SB590885	1
iGMDRD654	SL 0101-1	1
iGMDRD163	all trans Retinoic Acid	1
iGMDRD109	Gefitinib	1
iGMDRD119	Temsirolimus	1
iGMDRD1036	X17AAG	1
iGMDRD431	NU-7441	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TIGAR

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DATATYPES

CLASSFICATION

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