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iGMDRD109

Canonical SMILES: COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4

InChI: InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)

InChI Key: XGALLCVXEZPNRQ-UHFFFAOYSA-N

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Standard Name	CHEMBL	Pubchem CID	KEGG Drug ID	DRUGBANK ID	Drug Status	Drug targets (TTD)	Drug Type
Standard NameGefitinib CHEMBLCHEMBL939 Pubchem CID123631 KEGG Drug IDD01977 DRUGBANK IDDB00317 Drug StatusAlone Drug targets (TTD)DAP000657 Drug TypeSmall Molecule

Drug Class:

Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Inhibitors BCRP/ABCG2 Substrates Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors Heterocyclic Compounds Heterocyclic Compounds, 2-Ring Kinase Inhibitor P-glycoprotein/ABCB1 Inhibitors P-glycoprotein/ABCB1 Substrates Protein Kinase Inhibitors Receptor, Epidermal Growth Factor, antagonists & inhibitors Tyrosine Kinase Inhibitors

Drug Targets:

AKT1 EGFR (P00533)

Drug Pathways:

EGFR signaling MAPK signaling pathway ErbB signaling pathway Pathways in cancer Non-small cell lung cancer

Drug Synonyms:

Gefitinib (JAN/USAN/INN)Iressa (TN)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

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Gene ID	Gene Name	Model Num.
55872	PBK	1
3845	KRAS	9
5295	PIK3R1	1
4771	NF2	1

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Gene in drug-gene network: Network Plot

Models in Gefitinib

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

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