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iGMDRD109

Canonical SMILES: COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4

InChI: InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)

InChI Key: XGALLCVXEZPNRQ-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	KEGG Drug ID	DRUGBANK ID	Drug Status	Drug targets (TTD)	Drug Type
Gefitinib	CHEMBL939	123631	D01977	DB00317	Alone	DAP000657	Small Molecule

Drug Class:

Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Inhibitors BCRP/ABCG2 Substrates Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors Heterocyclic Compounds Heterocyclic Compounds, 2-Ring Kinase Inhibitor P-glycoprotein/ABCB1 Inhibitors P-glycoprotein/ABCB1 Substrates Protein Kinase Inhibitors Receptor, Epidermal Growth Factor, antagonists & inhibitors Tyrosine Kinase Inhibitors

Drug Targets:

AKT1 EGFR (P00533)

Drug Pathways:

EGFR signaling MAPK signaling pathway ErbB signaling pathway Pathways in cancer Non-small cell lung cancer

Drug Synonyms:

Gefitinib (JAN/USAN/INN)Iressa (TN)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
55872	PBK	1
3845	KRAS	9
5295	PIK3R1	1
4771	NF2	1
1111	CHEK1	1
7158	TP53BP1	1
64324	NSD1	1
25937	WWTR1	1
2064	ERBB2	1
898	CCNE1	1
7157	TP53	1
57111	RAB25	1
3105	HLA-A	1
8731	RNMT	2
5290	PIK3CA	2
675	BRCA2	1
1956	EGFR	231
673	BRAF	1
5728	PTEN	1
6009	RHEB	1
57103	TIGAR	1
5111	PCNA	1
4893	NRAS	1
2065	ERBB3	1
7403	KDM6A	1
54790	TET2	1
3480	IGF1R	1
595	CCND1	1

Gene in drug-gene network: Network Plot

Models in Gefitinib

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.