PBK


Summary: This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:611210
PHARMGKB IDPA134925802
Map Location8p21.1

GO terms in PBK


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005634 nucleus
BP NAS GO:0000278 mitotic cell cycle
BP IEA GO:0006468 protein phosphorylation
BP IEA GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
BP IEA GO:0032873 negative regulation of stress-activated MAPK cascade
BP IEA GO:0034644 cellular response to UV
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Gene expression in normal tissue: PBK

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined12Longevity regulating pathway1Apoptosis regulation1Metabolic pathways1EGFR signaling1PI3K/MTOR signaling1

Pathways in PBK


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Database
Pathway ID
Pathway Des.
wikipathways WP3879 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
wikipathways WP3888 VEGFA-VEGFR2 Signaling Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD255 SB225002 3
iGMDRD109 Gefitinib 1
iGMDRD434 BMS-536924 3
iGMDRD68 Paclitaxel 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PBK

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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