IGF1R


Summary: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
insulin like growth factor 1 receptorMIM:147370Ensembl:ENSG00000140443HGNC:HGNC:5465PA2969815q26.3

GO terms in IGF1R


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0001934positive regulation of protein phosphorylation
BPIMPGO:0006955immune response
BPTASGO:0007165signal transduction
BPIBAGO:0007275multicellular organism development
BPIMPGO:0008284positive regulation of cell proliferation
BPISSGO:0008286insulin receptor signaling pathway
BPIBAGO:0009968negative regulation of signal transduction
BPICGO:0014065phosphatidylinositol 3-kinase signaling
BPIBAGO:0030154cell differentiation
BPIMPGO:0030335positive regulation of cell migration
BPIBAGO:0033674positive regulation of kinase activity
BPIMPGO:0038083peptidyl-tyrosine autophosphorylation
BPIBAGO:0042593glucose homeostasis
BPIBAGO:0043066negative regulation of apoptotic process
BPIDAGO:0043066negative regulation of apoptotic process
BPISSGO:0043243positive regulation of protein complex disassembly
BPIDAGO:0046328regulation of JNK cascade
BPIDAGO:0046777protein autophosphorylation
BPIDAGO:0048009insulin-like growth factor receptor signaling pathway
BPIDAGO:0048015phosphatidylinositol-mediated signaling
BPIDAGO:0051262protein tetramerization
BPIDAGO:0051389inactivation of MAPKK activity
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPISSGO:0097062dendritic spine maintenance
BPIMPGO:0097242amyloid-beta clearance
BPIGIGO:1904646cellular response to amyloid-beta
CCIBAGO:0005737cytoplasm
CCISSGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCICGO:0005887integral component of plasma membrane
CCIBAGO:0005899insulin receptor complex
CCIDAGO:0016020membrane
CCIBAGO:0030424axon
CCIDAGO:0035867alphav-beta3 integrin-IGF-1-IGF1R complex
CCIDAGO:0043231intracellular membrane-bounded organelle
CCIBAGO:0043235receptor complex
CCIDAGO:0043235receptor complex
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIDAGO:0004713protein tyrosine kinase activity
MFIMPGO:0004713protein tyrosine kinase activity
MFTASGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFIBAGO:0005009insulin-activated receptor activity
MFIDAGO:0005010insulin-like growth factor-activated receptor activity
MFIDAGO:0005158insulin receptor binding
MFIPIGO:0005515protein binding
MFIDAGO:0005520insulin-like growth factor binding
MFIEAGO:0005524ATP binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFIDAGO:0031994insulin-like growth factor I binding
MFIPIGO:0031994insulin-like growth factor I binding
MFIPIGO:0042802identical protein binding
MFIPIGO:0043548phosphatidylinositol 3-kinase binding
MFIPIGO:0043559insulin binding
MFIBAGO:0043560insulin receptor substrate binding
MFIPIGO:0043560insulin receptor substrate binding

Gene expression in normal tissue: IGF1R

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IGF1R


DatabasePathway IDPathway Des.
biocartabadpathwayregulation of bad phosphorylation
biocartaigf1mtorpathwayskeletal muscle hypertrophy is regulated via akt-mtor pathway
biocartaigf1pathwayigf-1 signaling pathway
biocartaigf1rpathwaymultiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation
biocartalongevitypathwaythe igf-1 receptor and longevity
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-2428933SHC-related events triggered by IGF1R
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP254Apoptosis
wikipathwaysWP2593JAK-STAT
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP3850Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4180Ebola Virus Pathway on Host
wikipathwaysWP4186Somatroph axis (GH) and its relationship to dietary restriction and aging
wikipathwaysWP4217Ebola Virus Pathway on Host
wikipathwaysWP4223Ras Signaling
wikipathwaysWP474Endochondral Ossification
wikipathwaysWP481Insulin Signaling
wikipathwaysWP615Senescence and Autophagy in Cancer
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04114Oocyte meiosis - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04213Longevity regulating pathway - multiple species - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04520Adherens junction - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04730Long-term depression - Homo sapiens (human)
kegghsa04913Ovarian steroidogenesis - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
pidajdiss_2pathwayPosttranslational regulation of adherens junction stability and dissassembly
pidavb3_integrin_pathwayIntegrins in angiogenesis
pidecadherin_stabilization_pathwayStabilization and expansion of the E-cadherin adherens junction
pider_nongenomic_pathwayPlasma membrane estrogen receptor signaling
pidigf1_pathwayIGF1 pathway
pidshp2_pathwaySHP2 signaling
netpathPathway_LeptinLeptin
netpathPathway_TSHTSH

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD356PNU-746541
iGMDRD23Gossypol3
iGMDRD451Serdemetan3
iGMDRD131Erlotinib2
iGMDRD60Quinoclamine2
iGMDRD577BIX012946
iGMDRD926IGF1R Monoclonal Antibody1
iGMDRD100Zebularine4
iGMDRD188Piperlongumine3
iGMDRD74Idarubicin2
iGMDRD887Compound 23 citrate2
iGMDRD399Selumetinib3
iGMDRD8012,4-dideoxy-DC-45-A24
iGMDRD187BRD98766
iGMDRD782DC-45-A23
iGMDRD109Gefitinib1
iGMDRD474Avrainvillamide4
iGMDRD446LY 21832402
iGMDRD546BMS-7548072
iGMDRD144NSC953973
iGMDRD427ABT7372
iGMDRD889Compound 7d-cis5
iGMDRD387CHIR-990211
iGMDRD772BRD47703
iGMDRD126Tipifarnib5
iGMDRD353PD03259012
iGMDRD300Tozasertib1
iGMDRD505Pevonedistat3
iGMDRD886Compound 1541A2
iGMDRD871BRD63682
iGMDRD414MST-3122
iGMDRD286Nsc 6328393
iGMDRD872BRD71373
iGMDRD77Itraconazole2
iGMDRD705Nakiterpiosin3
iGMDRD434BMS-5369242
iGMDRD158NSC1415403
iGMDRD137Indisulam4
iGMDRD57Chloropentafluorobenzene2
iGMDRD341Triacsin c1
iGMDRD150RITA2
iGMDRD424Tamatinib5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IGF1R

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