IGF1R
Summary: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| insulin like growth factor 1 receptor | MIM:147370 | Ensembl:ENSG00000140443 | HGNC:HGNC:5465 | PA29698 | 15q26.3 |
GO terms in IGF1R
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IMP | GO:0006955 | immune response |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | ISS | GO:0008286 | insulin receptor signaling pathway |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IC | GO:0014065 | phosphatidylinositol 3-kinase signaling |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IMP | GO:0030335 | positive regulation of cell migration |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IMP | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | IBA | GO:0042593 | glucose homeostasis |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0043243 | positive regulation of protein complex disassembly |
| BP | IDA | GO:0046328 | regulation of JNK cascade |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0048009 | insulin-like growth factor receptor signaling pathway |
| BP | IDA | GO:0048015 | phosphatidylinositol-mediated signaling |
| BP | IDA | GO:0051262 | protein tetramerization |
| BP | IDA | GO:0051389 | inactivation of MAPKK activity |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | ISS | GO:0097062 | dendritic spine maintenance |
| BP | IMP | GO:0097242 | amyloid-beta clearance |
| BP | IGI | GO:1904646 | cellular response to amyloid-beta |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IC | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0005899 | insulin receptor complex |
| CC | IDA | GO:0016020 | membrane |
| CC | IBA | GO:0030424 | axon |
| CC | IDA | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IDA | GO:0043235 | receptor complex |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IDA | GO:0004713 | protein tyrosine kinase activity |
| MF | IMP | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IBA | GO:0005009 | insulin-activated receptor activity |
| MF | IDA | GO:0005010 | insulin-like growth factor-activated receptor activity |
| MF | IDA | GO:0005158 | insulin receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005520 | insulin-like growth factor binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IDA | GO:0031994 | insulin-like growth factor I binding |
| MF | IPI | GO:0031994 | insulin-like growth factor I binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0043548 | phosphatidylinositol 3-kinase binding |
| MF | IPI | GO:0043559 | insulin binding |
| MF | IBA | GO:0043560 | insulin receptor substrate binding |
| MF | IPI | GO:0043560 | insulin receptor substrate binding |
Gene expression in normal tissue: IGF1R
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IGF1R
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | badpathway | regulation of bad phosphorylation |
| biocarta | igf1mtorpathway | skeletal muscle hypertrophy is regulated via akt-mtor pathway |
| biocarta | igf1pathway | igf-1 signaling pathway |
| biocarta | igf1rpathway | multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation |
| biocarta | longevitypathway | the igf-1 receptor and longevity |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| reactome | R-HSA-2428924 | IGF1R signaling cascade |
| reactome | R-HSA-2428928 | IRS-related events triggered by IGF1R |
| reactome | R-HSA-2428933 | SHC-related events triggered by IGF1R |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3850 | Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4186 | Somatroph axis (GH) and its relationship to dietary restriction and aging |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP474 | Endochondral Ossification |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa04730 | Long-term depression - Homo sapiens (human) |
| kegg | hsa04913 | Ovarian steroidogenesis - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05218 | Melanoma - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
| pid | avb3_integrin_pathway | Integrins in angiogenesis |
| pid | ecadherin_stabilization_pathway | Stabilization and expansion of the E-cadherin adherens junction |
| pid | er_nongenomic_pathway | Plasma membrane estrogen receptor signaling |
| pid | igf1_pathway | IGF1 pathway |
| pid | shp2_pathway | SHP2 signaling |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_TSH | TSH |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD131 | Erlotinib | 2 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD926 | IGF1R Monoclonal Antibody | 1 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 4 |
| iGMDRD187 | BRD9876 | 6 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD109 | Gefitinib | 1 |
| iGMDRD474 | Avrainvillamide | 4 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD889 | Compound 7d-cis | 5 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD150 | RITA | 2 |
| iGMDRD424 | Tamatinib | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IGF1R
CLASSFICATION
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