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IGF1R

Summary: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameinsulin like growth factor 1 receptor OMIM IDMIM:147370 Ensembl IDEnsembl:ENSG00000140443 HGNC IDHGNC:HGNC:5465 PHARMGKB IDPA29698 Map Location15q26.3

Gene Categories:

CLINICALLY ACTIONABLE KINASE SERINE THREONINE KINASE DRUGGABLE GENOME TYROSINE KINASE

GO terms in IGF1R

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0001934	positive regulation of protein phosphorylation
BP	IMP	GO:0006955	immune response
BP	TAS	GO:0007165	signal transduction
BP	IBA	GO:0007275	multicellular organism development
BP	IMP	GO:0008284	positive regulation of cell proliferation
BP	ISS	GO:0008286	insulin receptor signaling pathway

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Gene expression in normal tissue: IGF1R

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IGF1R

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Database	Pathway ID	Pathway Des.
biocarta	badpathway	regulation of bad phosphorylation
biocarta	igf1mtorpathway	skeletal muscle hypertrophy is regulated via akt-mtor pathway
biocarta	igf1pathway	igf-1 signaling pathway
biocarta	igf1rpathway	multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation
biocarta	longevitypathway	the igf-1 receptor and longevity
reactome	R-HSA-162582	Signal Transduction

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD356	PNU-74654	1
iGMDRD23	Gossypol	3
iGMDRD451	Serdemetan	3
iGMDRD131	Erlotinib	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IGF1R

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.