RHEB
Summary: This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Ras homolog, mTORC1 binding | MIM:601293 | Ensembl:ENSG00000106615 | HGNC:HGNC:10011 | PA34389 | 7q36.1 |
Gene Categories:
TUMOR SUPPRESSORGO terms in RHEB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IEA | GO:0005681 | spliceosomal complex |
| CC | TAS | GO:0005765 | lysosomal membrane |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0005829 | cytosol |
| CC | TAS | GO:0016020 | membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | TAS | GO:0007050 | cell cycle arrest |
| BP | IEA | GO:0007165 | signal transduction |
| BP | TAS | GO:0016241 | regulation of macroautophagy |
| BP | IMP | GO:0032008 | positive regulation of TOR signaling |
| BP | IEA | GO:0048714 | positive regulation of oligodendrocyte differentiation |
| BP | IMP | GO:2000074 | regulation of type B pancreatic cell development |
| MF | IMP | GO:0000287 | magnesium ion binding |
| MF | TAS | GO:0003924 | GTPase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IMP | GO:0005525 | GTP binding |
| MF | ISS | GO:0005525 | GTP binding |
| MF | IMP | GO:0019003 | GDP binding |
| MF | IEA | GO:0019901 | protein kinase binding |
Gene expression in normal tissue: RHEB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RHEB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1632852 | Macroautophagy |
| reactome | R-HSA-165159 | mTOR signalling |
| reactome | R-HSA-166208 | mTORC1-mediated signalling |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK |
| reactome | R-HSA-5628897 | TP53 Regulates Metabolic Genes |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| biocarta | mtorpathway | mtor signaling pathway |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| pid | mtor_4pathway | mTOR signaling pathway |
| wikipathways | WP1471 | Target Of Rapamycin (TOR) Signaling |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| wikipathways | WP2035 | Follicle Stimulating Hormone (FSH) signaling pathway |
| wikipathways | WP2571 | Polycystic Kidney Disease Pathway |
| wikipathways | WP3676 | BDNF-TrkB Signaling |
| wikipathways | WP3844 | PI3K-AKT-mTOR signaling pathway and therapeutic opportunities |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| smpdb | SMP00682 | Leucine Stimulation on Insulin Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD109 | Gefitinib | 1 |
| iGMDRD769 | QL-XII-47 | 1 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD150 | RITA | 9 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD329 | Merck60 | 9 |
| iGMDRD178 | MG-132 | 1 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD245 | FH535 | 1 |
| iGMDRD300 | Tozasertib | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RHEB
CLASSFICATION
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