KDM6A

Summary: This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namelysine demethylase 6A
OMIM IDMIM:300128
Ensembl IDEnsembl:ENSG00000147050
HGNC IDHGNC:HGNC:12637
PHARMGKB IDPA37262
Map LocationXp11.3

GO terms in KDM6A


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
MF IEA GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
MF IBA GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding
MF IBA GO:0003682 chromatin binding
MF IBA GO:0031490 chromatin DNA binding
MF IEA GO:0031490 chromatin DNA binding
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Gene expression in normal tissue: KDM6A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined69RTK signaling6Apoptosis regulation4ERK MAPK signaling4PI3K/MTOR signaling3Cytoskeleton3Protein stability and degradation2DNA replication2Cell cycle2Biosynthesis of secondary metabolites2

Pathways in KDM6A


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Database
Pathway ID
Pathway Des.
wikipathways WP2857 Mesodermal Commitment Pathway
wikipathways WP3651 Pathways Affected in Adenoid Cystic Carcinoma
kegg hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-3214842 HDMs demethylate histones
reactome R-HSA-3247509 Chromatin modifying enzymes
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD554 CHEMBL1434137 3
iGMDRD136 Nutlin-3 1
iGMDRD579 PF750 3
iGMDRD772 BRD4770 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KDM6A

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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