KDM6A


Summary: This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
lysine demethylase 6AMIM:300128Ensembl:ENSG00000147050HGNC:HGNC:12637PA37262Xp11.3

GO terms in KDM6A


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0001190transcriptional activator activity, RNA polymerase II transcription factor binding
MFIBAGO:0003682chromatin binding
MFIBAGO:0031490chromatin DNA binding
MFIEAGO:0031490chromatin DNA binding
MFTASGO:0032452histone demethylase activity
MFIEAGO:0042802identical protein binding
MFIBAGO:0043565sequence-specific DNA binding
MFIEAGO:0046872metal ion binding
MFIEAGO:0051213dioxygenase activity
MFIBAGO:0071558histone demethylase activity (H3-K27 specific)
MFIEAGO:0071558histone demethylase activity (H3-K27 specific)
CCIBAGO:0000790nuclear chromatin
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0035097histone methyltransferase complex
CCIBAGO:0044666MLL3/4 complex
CCIDAGO:0044666MLL3/4 complex
BPIEAGO:0001701in utero embryonic development
BPIEAGO:0001843neural tube closure
BPIEAGO:0003007heart morphogenesis
BPIEAGO:0003016respiratory system process
BPISSGO:0006338chromatin remodeling
BPIEAGO:0010628positive regulation of gene expression
BPIEAGO:0032525somite rostral/caudal axis specification
BPIEAGO:0035264multicellular organism growth
BPIEAGO:0048333mesodermal cell differentiation
BPIEAGO:0048570notochord morphogenesis
BPISSGO:0051568histone H3-K4 methylation
BPIEAGO:0055114oxidation-reduction process
BPIEAGO:0060070canonical Wnt signaling pathway
BPIEAGO:0071557histone H3-K27 demethylation
BPIEAGO:0072358cardiovascular system development

Gene expression in normal tissue: KDM6A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KDM6A


DatabasePathway IDPathway Des.
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP3651Pathways Affected in Adenoid Cystic Carcinoma
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-3214842HDMs demethylate histones
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesis
reactomeR-HSA-5619507Activation of HOX genes during differentiation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD554CHEMBL14341373
iGMDRD136Nutlin-31
iGMDRD579PF7503
iGMDRD772BRD47702
iGMDRD1008SR-II-138A6
iGMDRD387CHIR-990211
iGMDRD599Salermide1
iGMDRD144NSC953973
iGMDRD494Neopeltolide3
iGMDRD446LY 21832401
iGMDRD193Fqi16
iGMDRD163all trans Retinoic Acid2
iGMDRD280CYTOCHALASIN B2
iGMDRD634SCHEMBL26080412
iGMDRD491TAE-6841
iGMDRD270Ciclosporin3
iGMDRD134Sorafenib1
iGMDRD109Gefitinib1
iGMDRD255SB2250021
iGMDRD782DC-45-A24
iGMDRD30917AAG1
iGMDRD870BRD636101
iGMDRD885Compound 1103
iGMDRD441TW 373
iGMDRD887Compound 23 citrate2
iGMDRD100Zebularine2
iGMDRD562Navitoclax2
iGMDRD577BIX012944
iGMDRD131Erlotinib1
iGMDRD690PRIMA-1MET2
iGMDRD268Cerulenin3
iGMDRD598QS-112
iGMDRD486Tosedostat1
iGMDRD347Y-399831
iGMDRD607Ubistatin B3
iGMDRD512nutlin 33
iGMDRD424Tamatinib4
iGMDRD345Compound 10b [PMID: 11504634]1
iGMDRD456Crizotinib1
iGMDRD116CD4373
iGMDRD292NSC878771
iGMDRD85Ursolic acid4
iGMDRD536PLX-47201
iGMDRD177Teniposide6
iGMDRD278TTNPB3
iGMDRD434BMS-5369241
iGMDRD6AM-5801
iGMDRD267Oligomycin A1
iGMDRD504Obatoclax1
iGMDRD459RO-33061
iGMDRD481Dactolisib6
iGMDRD68Paclitaxel1
iGMDRD415LE-1354
iGMDRD414MST-3121
iGMDRD3PD-1730741
iGMDRD246NPC263
iGMDRD472PF-5622711
iGMDRD505Pevonedistat1
iGMDRD82Quiflapon6
iGMDRD409Saracatinib1
iGMDRD126Tipifarnib3
iGMDRD425ERASTIN3
iGMDRD420Leucascandrolide A4
iGMDRD443Linifanib1
iGMDRD427ABT7376
iGMDRD781Sirolimus3
iGMDRD484Pluripotin2
iGMDRD483SCH-5290742
iGMDRD748PHA-6657521
iGMDRD316N9-Isopropyl-olomoucine3
iGMDRD639YK 4-2791
iGMDRD466Chaetocin5
iGMDRD394BX-7951
iGMDRD470Trametinib1
iGMDRD513BML-2593
iGMDRD493GSK269962A1
iGMDRD284Palbociclib1
iGMDRD171Pemetrexed3
iGMDRD187BRD98764
iGMDRD52Rotenone1
iGMDRD399Selumetinib3
iGMDRD188Piperlongumine4
iGMDRD133Lapatinib1
iGMDRD506Fedratinib1
iGMDRD888Compound 442
iGMDRD190Nilotinib2
iGMDRD64Parbendazole6
iGMDRD524ISX-96
iGMDRD356PNU-746541
iGMDRD23Gossypol2
iGMDRD532Olaparib1
iGMDRD150RITA2
iGMDRD352PD-03259011
iGMDRD314Tanespimycin1
iGMDRD123Isoevodiamine6
iGMDRD945ML2142
iGMDRD605AZD64821
iGMDRD1002rTRAIL1
iGMDRD158NSC1415408
iGMDRD202Curcumin1
iGMDRD137Indisulam1
iGMDRD103SN-384
iGMDRD215CCT0070932
iGMDRD221Tamoxifen1
iGMDRD289Parthenolide5
iGMDRD105Triptolide3
iGMDRD396AS6012451
iGMDRD213SMR0000686502
iGMDRD871BRD63681
iGMDRD286Nsc 6328395
iGMDRD366PI-1033
iGMDRD329Merck604
iGMDRD662JQ-13
iGMDRD263AACOCF32
iGMDRD147Prima-13

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KDM6A

​​​​