PCNA
Summary: The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:176740 Ensembl IDEnsembl:ENSG00000132646 HGNC IDHGNC:HGNC:8729 PHARMGKB IDPA263 Map Location20p12.3 |
GO terms in PCNA
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | TAS | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle |
BP | TAS | GO:0000723 | telomere maintenance |
BP | IBA | GO:0006272 | leading strand elongation |
BP | TAS | GO:0006283 | transcription-coupled nucleotide-excision repair |
BP | TAS | GO:0006296 | nucleotide-excision repair, DNA incision, 5'-to lesion |
BP | TAS | GO:0006297 | nucleotide-excision repair, DNA gap filling |
Gene expression in normal tissue: PCNA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PCNA
Loading, please wait...
Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa03030 | DNA replication - Homo sapiens (human) |
kegg | hsa03410 | Base excision repair - Homo sapiens (human) |
kegg | hsa03420 | Nucleotide excision repair - Homo sapiens (human) |
kegg | hsa03430 | Mismatch repair - Homo sapiens (human) |
kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
kegg | hsa04530 | Tight junction - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in PCNA
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |