PCNA
Summary: The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| proliferating cell nuclear antigen | MIM:176740 | Ensembl:ENSG00000132646 | HGNC:HGNC:8729 | PA263 | 20p12.3 |
GO terms in PCNA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle |
| BP | TAS | GO:0000723 | telomere maintenance |
| BP | IBA | GO:0006272 | leading strand elongation |
| BP | TAS | GO:0006283 | transcription-coupled nucleotide-excision repair |
| BP | TAS | GO:0006296 | nucleotide-excision repair, DNA incision, 5'-to lesion |
| BP | TAS | GO:0006297 | nucleotide-excision repair, DNA gap filling |
| BP | IBA | GO:0006298 | mismatch repair |
| BP | IDA | GO:0006298 | mismatch repair |
| BP | TAS | GO:0006298 | mismatch repair |
| BP | TAS | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| BP | IEA | GO:0007507 | heart development |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | TAS | GO:0016567 | protein ubiquitination |
| BP | IBA | GO:0019985 | translesion synthesis |
| BP | IDA | GO:0019985 | translesion synthesis |
| BP | TAS | GO:0019985 | translesion synthesis |
| BP | IEP | GO:0030855 | epithelial cell differentiation |
| BP | ISS | GO:0031297 | replication fork processing |
| BP | IDA | GO:0032077 | positive regulation of deoxyribonuclease activity |
| BP | TAS | GO:0032201 | telomere maintenance via semi-conservative replication |
| BP | IEA | GO:0032355 | response to estradiol |
| BP | TAS | GO:0033683 | nucleotide-excision repair, DNA incision |
| BP | IDA | GO:0034644 | cellular response to UV |
| BP | TAS | GO:0042276 | error-prone translesion synthesis |
| BP | TAS | GO:0042769 | DNA damage response, detection of DNA damage |
| BP | IEA | GO:0044849 | estrous cycle |
| BP | IMP | GO:0045739 | positive regulation of DNA repair |
| BP | IMP | GO:0045740 | positive regulation of DNA replication |
| BP | IEA | GO:0046686 | response to cadmium ion |
| BP | IEA | GO:0070301 | cellular response to hydrogen peroxide |
| BP | TAS | GO:0070987 | error-free translesion synthesis |
| BP | IEA | GO:0071548 | response to dexamethasone |
| BP | IEA | GO:0097421 | liver regeneration |
| BP | IEA | GO:1902065 | response to L-glutamate |
| BP | ISS | GO:1902990 | mitotic telomere maintenance via semi-conservative replication |
| CC | HDA | GO:0000784 | nuclear chromosome, telomeric region |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005657 | replication fork |
| CC | TAS | GO:0005663 | DNA replication factor C complex |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0016604 | nuclear body |
| CC | TAS | GO:0030894 | replisome |
| CC | IDA | GO:0043596 | nuclear replication fork |
| CC | IBA | GO:0043626 | PCNA complex |
| CC | IDA | GO:0043626 | PCNA complex |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0070557 | PCNA-p21 complex |
| MF | IDA | GO:0000701 | purine-specific mismatch base pair DNA N-glycosylase activity |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0003684 | damaged DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IEA | GO:0030331 | estrogen receptor binding |
| MF | IBA | GO:0030337 | DNA polymerase processivity factor activity |
| MF | IPI | GO:0030971 | receptor tyrosine kinase binding |
| MF | IDA | GO:0032139 | dinucleotide insertion or deletion binding |
| MF | IDA | GO:0032405 | MutLalpha complex binding |
| MF | IPI | GO:0035035 | histone acetyltransferase binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0070182 | DNA polymerase binding |
Gene expression in normal tissue: PCNA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PCNA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03030 | DNA replication - Homo sapiens (human) |
| kegg | hsa03410 | Base excision repair - Homo sapiens (human) |
| kegg | hsa03420 | Nucleotide excision repair - Homo sapiens (human) |
| kegg | hsa03430 | Mismatch repair - Homo sapiens (human) |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| pid | bard1pathway | BARD1 signaling events |
| pid | era_genomic_pathway | Validated nuclear estrogen receptor alpha network |
| pid | p53downstreampathway | Direct p53 effectors |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP1858 | Mitotic G1-G1-S phases |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
| wikipathways | WP259 | Nifedipine Activity |
| wikipathways | WP3941 | Oxidative Damage |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP45 | G1 to S cell cycle control |
| wikipathways | WP466 | DNA Replication |
| wikipathways | WP531 | Mismatch repair |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| smpdb | SMP00478 | Nucleotide Excision Repair |
| reactome | R-HSA-110312 | Translesion synthesis by REV1 |
| reactome | R-HSA-110313 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| reactome | R-HSA-110314 | Recognition of DNA damage by PCNA-containing replication complex |
| reactome | R-HSA-110320 | Translesion Synthesis by POLH |
| reactome | R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| reactome | R-HSA-1362277 | Transcription of E2F targets under negative control by DREAM complex |
| reactome | R-HSA-1538133 | G0 and Early G1 |
| reactome | R-HSA-157579 | Telomere Maintenance |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-174411 | Polymerase switching on the C-strand of the telomere |
| reactome | R-HSA-174414 | Processive synthesis on the C-strand of the telomere |
| reactome | R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis |
| reactome | R-HSA-174437 | Removal of the Flap Intermediate from the C-strand |
| reactome | R-HSA-180786 | Extension of Telomeres |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-4615885 | SUMOylation of DNA replication proteins |
| reactome | R-HSA-5358508 | Mismatch Repair |
| reactome | R-HSA-5358508 | Mismatch Repair |
| reactome | R-HSA-5358565 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) |
| reactome | R-HSA-5358606 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
| reactome | R-HSA-539107 | Activation of E2F1 target genes at G1/S |
| reactome | R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair |
| reactome | R-HSA-5655862 | Translesion synthesis by POLK |
| reactome | R-HSA-5656121 | Translesion synthesis by POLI |
| reactome | R-HSA-5656169 | Termination of translesion DNA synthesis |
| reactome | R-HSA-5685942 | HDR through Homologous Recombination (HRR) |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| reactome | R-HSA-5696397 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| reactome | R-HSA-5696398 | Nucleotide Excision Repair |
| reactome | R-HSA-5696399 | Global Genome Nucleotide Excision Repair (GG-NER) |
| reactome | R-HSA-5696400 | Dual Incision in GG-NER |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| reactome | R-HSA-6782135 | Dual incision in TC-NER |
| reactome | R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| reactome | R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes |
| reactome | R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest |
| reactome | R-HSA-69091 | Polymerase switching |
| reactome | R-HSA-69109 | Leading Strand Synthesis |
| reactome | R-HSA-69166 | Removal of the Flap Intermediate |
| reactome | R-HSA-69183 | Processive synthesis on the lagging strand |
| reactome | R-HSA-69186 | Lagging Strand Synthesis |
| reactome | R-HSA-69190 | DNA strand elongation |
| reactome | R-HSA-69205 | G1/S-Specific Transcription |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69239 | Synthesis of DNA |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69306 | DNA Replication |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73884 | Base Excision Repair |
| reactome | R-HSA-73886 | Chromosome Maintenance |
| reactome | R-HSA-73893 | DNA Damage Bypass |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-73933 | Resolution of Abasic Sites (AP sites) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8852135 | Protein ubiquitination |
| reactome | R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| biocarta | p53pathway | p53 signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD470 | Trametinib | 1 |
| iGMDRD778 | SCHEMBL13586708 | 1 |
| iGMDRD401 | Afatinib | 1 |
| iGMDRD450 | JNJ-26854165 | 1 |
| iGMDRD184 | IPA-3 | 1 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD112 | Methotrexate | 1 |
| iGMDRD382 | CEP-701 | 1 |
| iGMDRD41 | Imatinib | 1 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD225 | AC1MD3YP | 1 |
| iGMDRD185 | DMOG | 1 |
| iGMDRD323 | Leptomycin B | 1 |
| iGMDRD133 | Lapatinib | 1 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD582 | MLN 2238 | 1 |
| iGMDRD439 | KW-2449 | 1 |
| iGMDRD109 | Gefitinib | 1 |
| iGMDRD156 | HLI-373 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PCNA
CLASSFICATION
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