PCNA


Summary: The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in PCNA


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
BP TAS GO:0000723 telomere maintenance
BP IBA GO:0006272 leading strand elongation
BP TAS GO:0006283 transcription-coupled nucleotide-excision repair
BP TAS GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
BP TAS GO:0006297 nucleotide-excision repair, DNA gap filling
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Gene expression in normal tissue: PCNA

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 22

Gene-drug pathway distribution

undefined7EGFR signaling2RTK signaling1Chromatin histone acetylation1Breast cancer1Metabolic pathways1Other, kinases1Metabolism1Purine metabolism1p53 pathway1

Pathways in PCNA


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Database
Pathway ID
Pathway Des.
kegg hsa03030 DNA replication - Homo sapiens (human)
kegg hsa03410 Base excision repair - Homo sapiens (human)
kegg hsa03420 Nucleotide excision repair - Homo sapiens (human)
kegg hsa03430 Mismatch repair - Homo sapiens (human)
kegg hsa04110 Cell cycle - Homo sapiens (human)
kegg hsa04530 Tight junction - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD470 Trametinib 1
iGMDRD778 SCHEMBL13586708 1
iGMDRD401 Afatinib 1
iGMDRD450 JNJ-26854165 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PCNA

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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