MLST8
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| MTOR associated protein, LST8 homolog | MIM:612190 | Ensembl:ENSG00000167965 | HGNC:HGNC:24825 | PA165450213 | 16p13.3 |
GO terms in MLST8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007050 | cell cycle arrest |
| BP | TAS | GO:0016241 | regulation of macroautophagy |
| BP | IEA | GO:0030838 | positive regulation of actin filament polymerization |
| BP | IBA | GO:0031929 | TOR signaling |
| BP | IMP | GO:0032008 | positive regulation of TOR signaling |
| BP | TAS | GO:0032148 | activation of protein kinase B activity |
| BP | IBA | GO:0032956 | regulation of actin cytoskeleton organization |
| BP | IMP | GO:0032956 | regulation of actin cytoskeleton organization |
| BP | IMP | GO:0038202 | TORC1 signaling |
| BP | IEA | GO:0043087 | regulation of GTPase activity |
| BP | IEA | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0071902 | positive regulation of protein serine/threonine kinase activity |
| BP | TAS | GO:1900034 | regulation of cellular response to heat |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0031931 | TORC1 complex |
| CC | IDA | GO:0031931 | TORC1 complex |
| CC | IBA | GO:0031932 | TORC2 complex |
| CC | IDA | GO:0031932 | TORC2 complex |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0043539 | protein serine/threonine kinase activator activity |
Gene expression in normal tissue: MLST8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MLST8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP1471 | Target Of Rapamycin (TOR) Signaling |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4011 | Steatosis AOP |
| wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP585 | Interferon type I signaling pathways |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| pid | cxcr3pathway | CXCR3-mediated signaling events |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | lkb1_pathway | LKB1 signaling events |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | mtor_4pathway | mTOR signaling pathway |
| pid | pi3kciaktpathway | Class I PI3K signaling events mediated by Akt |
| kegg | hsa04136 | Autophagy - other - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1632852 | Macroautophagy |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-165159 | mTOR signalling |
| reactome | R-HSA-166208 | mTORC1-mediated signalling |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-3371571 | HSF1-dependent transactivation |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK |
| reactome | R-HSA-388841 | Costimulation by the CD28 family |
| reactome | R-HSA-389356 | CD28 co-stimulation |
| reactome | R-HSA-389357 | CD28 dependent PI3K/Akt signaling |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-5218920 | VEGFR2 mediated vascular permeability |
| reactome | R-HSA-5628897 | TP53 Regulates Metabolic Genes |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer |
| reactome | R-HSA-6804757 | Regulation of TP53 Degradation |
| reactome | R-HSA-6806003 | Regulation of TP53 Expression and Degradation |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MLST8
CLASSFICATION
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