SCUBE1
Summary: This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology. [provided by RefSeq, Oct 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| signal peptide, CUB domain and EGF like domain containing 1 | MIM:611746 | Ensembl:ENSG00000159307 | HGNC:HGNC:13441 | PA35019 | 22q13.2 |
GO terms in SCUBE1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005509 | calcium ion binding |
| MF | IDA | GO:0042802 | identical protein binding |
| MF | IDA | GO:0046982 | protein heterodimerization activity |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0009897 | external side of plasma membrane |
| CC | IBA | GO:0009986 | cell surface |
| CC | IDA | GO:0009986 | cell surface |
| CC | IDA | GO:0019897 | extrinsic component of plasma membrane |
| BP | NAS | GO:0006954 | inflammatory response |
| BP | IBA | GO:0007165 | signal transduction |
| BP | NAS | GO:0007512 | adult heart development |
| BP | NAS | GO:0007596 | blood coagulation |
| BP | NAS | GO:0009791 | post-embryonic development |
| BP | TAS | GO:0022617 | extracellular matrix disassembly |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | NAS | GO:0045446 | endothelial cell differentiation |
| BP | IEA | GO:0045880 | positive regulation of smoothened signaling pathway |
| BP | IPI | GO:0051260 | protein homooligomerization |
Gene expression in normal tissue: SCUBE1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SCUBE1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SCUBE1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.