Summary: This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology. [provided by RefSeq, Oct 2011].

signal peptide, CUB domain and EGF like domain containing 1MIM:611746Ensembl:ENSG00000159307HGNC:HGNC:13441PA3501922q13.2

GO terms in SCUBE1

Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0005509calcium ion binding
MFIDAGO:0042802identical protein binding
MFIDAGO:0046982protein heterodimerization activity
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCTASGO:0005886plasma membrane
CCIDAGO:0009897external side of plasma membrane
CCIBAGO:0009986cell surface
CCIDAGO:0009986cell surface
CCIDAGO:0019897extrinsic component of plasma membrane
BPNASGO:0006954inflammatory response
BPIBAGO:0007165signal transduction
BPNASGO:0007512adult heart development
BPNASGO:0007596blood coagulation
BPNASGO:0009791post-embryonic development
BPTASGO:0022617extracellular matrix disassembly
BPIBAGO:0030154cell differentiation
BPNASGO:0045446endothelial cell differentiation
BPIEAGO:0045880positive regulation of smoothened signaling pathway
BPIPIGO:0051260protein homooligomerization

Gene expression in normal tissue: SCUBE1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SCUBE1

DatabasePathway IDPathway Des.
reactomeR-HSA-1474228Degradation of the extracellular matrix
reactomeR-HSA-1474244Extracellular matrix organization

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SCUBE1