KDR
Summary: Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:191306 Ensembl IDEnsembl:ENSG00000128052 HGNC IDHGNC:HGNC:6307 PHARMGKB IDPA30086 Map Location4q12 | |||||
GO terms in KDR
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | EXP | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IDA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | TAS | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
Gene expression in normal tissue: KDR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KDR
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | avb3_integrin_pathway | Integrins in angiogenesis |
| pid | hes_heypathway | Notch-mediated HES/HEY network |
| pid | hif2pathway | HIF-2-alpha transcription factor network |
| pid | integrin3_pathway | Beta3 integrin cell surface interactions |
| pid | s1p_s1p1_pathway | S1P1 pathway |
| pid | shp2_pathway | SHP2 signaling |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KDR
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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