iGMDRD422

Canonical SMILES: CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F

InChI: InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)

InChI Key: FNHKPVJBJVTLMP-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameRegorafenib
CHEMBLCHEMBL1946170
Pubchem CID11167600
DRUGBANK IDDB08896
Drug StatusAlone
Drug TypeSmall Molecule


Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

12reactome: Signal Transduction10reactome: Signaling by Receptor Tyrosine Kinases7reactome: Disease6kegg: Ras signaling pathway - Homo sapiens (human)6wikipathways: Ras Signaling6wikipathways: PI3K-Akt Signaling Pathway6kegg: PI3K-Akt signaling pathway - Homo sapiens (human)6kegg: Rap1 signaling pathway - Homo sapiens (human)6wikipathways: Focal Adhesion-PI3K-Akt-mTOR-signaling pathway5kegg: HTLV-I infection - Homo sapiens (human)

Drug-gene GO enrichments

11CC: plasma membrane10CC: cytoplasm8MF: protein tyrosine kinase activity8CC: nucleus8BP: positive regulation of ERK1 and ERK2 cascade7MF: protein binding7MF: transmembrane receptor protein tyrosine kinase activity7BP: positive regulation of cell proliferation6BP: negative regulation of apoptotic process6BP: positive regulation of MAPK cascade

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
7514 XPO1 1
3845 KRAS 10
5159 PDGFRB 1
3791 KDR 1
Showing 1 to 4 of 8 rows

Gene in drug-gene network: Network Plot

Models in Regorafenib

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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