TTF1
Summary: This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transcription termination factor 1 | MIM:600777 | Ensembl:ENSG00000125482 | HGNC:HGNC:12397 | PA37062 | 9q34.13 |
GO terms in TTF1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | NAS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| BP | NAS | GO:0006353 | DNA-templated transcription, termination |
| BP | TAS | GO:0006363 | termination of RNA polymerase I transcription |
| BP | IEA | GO:0008156 | negative regulation of DNA replication |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
Gene expression in normal tissue: TTF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TTF1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression |
| reactome | R-HSA-427413 | NoRC negatively regulates rRNA expression |
| reactome | R-HSA-5250913 | Positive epigenetic regulation of rRNA expression |
| reactome | R-HSA-5250941 | Negative epigenetic regulation of rRNA expression |
| reactome | R-HSA-5668914 | Diseases of metabolism |
| reactome | R-HSA-5683826 | Surfactant metabolism |
| reactome | R-HSA-5687613 | Diseases associated with surfactant metabolism |
| reactome | R-HSA-5688031 | Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS) |
| reactome | R-HSA-73762 | RNA Polymerase I Transcription Initiation |
| reactome | R-HSA-73854 | RNA Polymerase I Promoter Clearance |
| reactome | R-HSA-73863 | RNA Polymerase I Transcription Termination |
| reactome | R-HSA-73863 | RNA Polymerase I Transcription Termination |
| reactome | R-HSA-73864 | RNA Polymerase I Transcription |
| reactome | R-HSA-73864 | RNA Polymerase I Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| kegg | hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD422 | Regorafenib | 1 |
| iGMDRD491 | TAE-684 | 1 |
| iGMDRD439 | KW-2449 | 1 |
| iGMDRD622 | BRD-K78574327 | 1 |
| iGMDRD379 | BIBR-1532 | 1 |
| iGMDRD272 | GSK-3 Inhibitor IX | 1 |
| iGMDRD620 | BRD-K41334119 | 1 |
| iGMDRD431 | NU-7441 | 1 |
| iGMDRD552 | AZD-1775 | 1 |
| iGMDRD625 | BRD-K84807411 | 1 |
| iGMDRD304 | CH 55 | 1 |
| iGMDRD602 | Foretinib | 1 |
| iGMDRD382 | CEP-701 | 1 |
| iGMDRD262 | KU-55933 | 1 |
| iGMDRD410 | Ko-143 | 1 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD659 | Avagacestat (BMS-708163) | 1 |
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD844 | BRD-A94377914 | 1 |
| iGMDRD78 | Topotecan | 1 |
| iGMDRD385 | CD1530 | 1 |
| iGMDRD154 | NSC23766 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TTF1
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