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iGMDRD78

Canonical SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=C(C5=C4)CN(C)C)O)O

InChI: InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1

InChI Key: UCFGDBYHRUNTLO-QHCPKHFHSA-N

Standard Name	CHEMBL	Pubchem CID	KEGG Drug ID	DRUGBANK ID	Drug Status	Drug targets (TTD)	Drug Type
Topotecan	CHEMBL1607 CHEMBL84	60700	D02168	DB01030	Alone	DAP000648	Small Molecule

Drug Class:

Alkaloids Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Substrates Camptothecin Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors Heterocyclic Compounds Immunosuppressive Agents Myelosuppressive Agents P-glycoprotein/ABCB1 Substrates Topoisomerase I Inhibitors Topoisomerase Inhibitors Cytotoxic

Drug Targets:

TOP1 (P11387)TOP1MT (Q969P6)DNA

Drug Pathways:

Bile secretion

Drug Synonyms:

Topotecan hydrochloride (USAN)Nogitecan hydrochloride (JAN)Hycamtin (TN)Potactasol (TN)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
7514	XPO1	1
2956	MSH6	1
4086	SMAD1	1
54658	UGT1A1	1
7270	TTF1	1
7150	TOP1	1
9223	MAGI1	1
142	PARP1	1
1803	DPP4	1

Gene in drug-gene network: Network Plot

Models in Topotecan

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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.