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TOP1

Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
DNA topoisomerase I	MIM:126420	Ensembl:ENSG00000198900	HGNC:HGNC:11986	PA353	20q12

Gene Categories:

DRUG RESISTANCE DRUGGABLE GENOME CLINICALLY ACTIONABLE SERINE THREONINE KINASE KINASE

GO terms in TOP1

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0006260	DNA replication
BP	IBA	GO:0006265	DNA topological change
BP	IDA	GO:0006265	DNA topological change
BP	IMP	GO:0006265	DNA topological change
BP	IBA	GO:0006338	chromatin remodeling
BP	IMP	GO:0006338	chromatin remodeling
BP	IBA	GO:0007059	chromosome segregation
BP	IEP	GO:0007623	circadian rhythm
BP	NAS	GO:0012501	programmed cell death
BP	IEA	GO:0016032	viral process
BP	NAS	GO:0016310	phosphorylation
BP	IMP	GO:0018105	peptidyl-serine phosphorylation
BP	IMP	GO:0032922	circadian regulation of gene expression
BP	IEA	GO:0040016	embryonic cleavage
BP	IEP	GO:0042493	response to drug
CC	IDA	GO:0000228	nuclear chromosome
CC	IDA	GO:0000932	P-body
CC	IDA	GO:0001650	fibrillar center
CC	HDA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005654	nucleoplasm
CC	IMP	GO:0005654	nucleoplasm
CC	TAS	GO:0005654	nucleoplasm
CC	IBA	GO:0005730	nucleolus
CC	IDA	GO:0005730	nucleolus
CC	IMP	GO:0005730	nucleolus
CC	IMP	GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)
CC	IBA	GO:0031298	replication fork protection complex
CC	IMP	GO:0032993	protein-DNA complex
CC	IEA	GO:0043204	perikaryon
MF	IDA	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IDA	GO:0003677	DNA binding
MF	IMP	GO:0003677	DNA binding
MF	IDA	GO:0003682	chromatin binding
MF	IMP	GO:0003690	double-stranded DNA binding
MF	IMP	GO:0003697	single-stranded DNA binding
MF	HDA	GO:0003723	RNA binding
MF	IBA	GO:0003917	DNA topoisomerase type I activity
MF	IDA	GO:0003917	DNA topoisomerase type I activity
MF	IMP	GO:0003917	DNA topoisomerase type I activity
MF	IMP	GO:0004674	protein serine/threonine kinase activity
MF	IPI	GO:0005515	protein binding
MF	IMP	GO:0005524	ATP binding
MF	IPI	GO:0019904	protein domain specific binding
MF	IMP	GO:0097100	supercoiled DNA binding

Gene expression in normal tissue: TOP1

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TOP1

Database	Pathway ID	Pathway Des.
reactome	R-HSA-2990846	SUMOylation
reactome	R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-4615885	SUMOylation of DNA replication proteins
reactome	R-HSA-597592	Post-translational protein modification
smpdb	SMP00433	Irinotecan Action Pathway
smpdb	SMP00600	Irinotecan Metabolism Pathway
pid	caspase_pathway	Caspase Cascade in Apoptosis
pharmgkb	PA2029	Irinotecan Pathway, Pharmacodynamics
netpath	Pathway_AndrogenReceptor	AndrogenReceptor

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD359	OSW-1	3
iGMDRD945	ML214	2
iGMDRD152	179324-69-7	2
iGMDRD78	Topotecan	1
iGMDRD116	CD437	3
iGMDRD84	Lovastatin acid	1
iGMDRD210	AC55649	1
iGMDRD80	Irinotecan	2
iGMDRD577	BIX01294	1
iGMDRD329	Merck60	6
iGMDRD562	Navitoclax	3
iGMDRD231	Importazole	2
iGMDRD18	Cyclophosphamide	1
iGMDRD105	Triptolide	2
iGMDRD288	Carboplatin	1
iGMDRD202	Curcumin	3
iGMDRD138	PX 12	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TOP1

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.