TOP1
Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:126420 Ensembl IDEnsembl:ENSG00000198900 HGNC IDHGNC:HGNC:11986 PHARMGKB IDPA353 Map Location20q12 |
GO terms in TOP1
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IBA | GO:0006260 | DNA replication |
BP | IBA | GO:0006265 | DNA topological change |
BP | IDA | GO:0006265 | DNA topological change |
BP | IMP | GO:0006265 | DNA topological change |
BP | IBA | GO:0006338 | chromatin remodeling |
BP | IMP | GO:0006338 | chromatin remodeling |
Gene expression in normal tissue: TOP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TOP1
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-2990846 | SUMOylation |
reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-4615885 | SUMOylation of DNA replication proteins |
reactome | R-HSA-597592 | Post-translational protein modification |
smpdb | SMP00433 | Irinotecan Action Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in TOP1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |