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TOP1

Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameDNA topoisomerase I OMIM IDMIM:126420 Ensembl IDEnsembl:ENSG00000198900 HGNC IDHGNC:HGNC:11986 PHARMGKB IDPA353 Map Location20q12

Gene Categories:

DRUG RESISTANCE DRUGGABLE GENOME CLINICALLY ACTIONABLE SERINE THREONINE KINASE KINASE

GO terms in TOP1

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0006260	DNA replication
BP	IBA	GO:0006265	DNA topological change
BP	IDA	GO:0006265	DNA topological change
BP	IMP	GO:0006265	DNA topological change
BP	IBA	GO:0006338	chromatin remodeling
BP	IMP	GO:0006338	chromatin remodeling

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Gene expression in normal tissue: TOP1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TOP1

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-2990846	SUMOylation
reactome	R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-4615885	SUMOylation of DNA replication proteins
reactome	R-HSA-597592	Post-translational protein modification
smpdb	SMP00433	Irinotecan Action Pathway

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD359	OSW-1	3
iGMDRD945	ML214	2
iGMDRD152	179324-69-7	2
iGMDRD78	Topotecan	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TOP1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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