TOP1


Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:126420
PHARMGKB IDPA353
Map Location20q12

GO terms in TOP1


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IBA GO:0006260 DNA replication
BP IBA GO:0006265 DNA topological change
BP IDA GO:0006265 DNA topological change
BP IMP GO:0006265 DNA topological change
BP IBA GO:0006338 chromatin remodeling
BP IMP GO:0006338 chromatin remodeling
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Gene expression in normal tissue: TOP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TOP1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-2990846 SUMOylation
reactome R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
reactome R-HSA-392499 Metabolism of proteins
reactome R-HSA-4615885 SUMOylation of DNA replication proteins
reactome R-HSA-597592 Post-translational protein modification
smpdb SMP00433 Irinotecan Action Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD359 OSW-1 3
iGMDRD945 ML214 2
iGMDRD152 179324-69-7 2
iGMDRD78 Topotecan 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TOP1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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