iGMDRD439

Canonical SMILES: C1CN(CCN1)C(=O)C2=CC=C(C=C2)C=CC3=NNC4=CC=CC=C43

InChI: InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+

InChI Key: YYLKKYCXAOBSRM-JXMROGBWSA-N

Loading, please wait...
Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameKW-2449
Pubchem CID11427600
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: undefined model num: 3undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 19

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Loading, please wait...
Gene ID
Gene Name
Model Num.
7514 XPO1 1
2956 MSH6 1
4170 MCL1 1
5159 PDGFRB 1
Showing 1 to 4 of 14 rows rows per page

Gene in drug-gene network: Network Plot

CAY10618CAY10618tivozanibtivozanibHSCI1_000270HSCI1_000270docetaxel in KRAS mutantdocetaxel in KRAS mutantNVP-231NVP-231SB-743921SB-743921daporinaddaporinadCD437CD437DPP4DPP4SMAD1SMAD1IdarubicinIdarubicinRITARITAFK 866FK 866ISX-9ISX-9BML-259BML-259SR-II-138ASR-II-138ASepantroniumSepantroniumGMX1778GMX1778gossypolgossypolchaetocinchaetocinCompound 10b [PMID: 11504634]Compound 10b [PMID: 11504634]Ro 28-1675Ro 28-1675SCHEMBL2608041SCHEMBL2608041zebularinezebularinePF750PF750Fqi1Fqi1VDAC1VDAC1selumetinib in BRAF mutant tumorsselumetinib in BRAF mutant tumorspyrvinium pamoatepyrvinium pamoatetipifarnib-P2tipifarnib-P2OSI-906 (Linsitinib)OSI-906 (Linsitinib)BMS-536924BMS-536924BIX01294BIX01294CHIR-99021CHIR-99021PNU-74654PNU-74654isoevodiamineisoevodiamineGW-843682XGW-843682XCompound.7d.cisCompound.7d.cisABT737ABT737Merck60Merck60PK-11195PK-11195fumonisin.B1fumonisin.B1LY 2183240LY 2183240Tyrphostin AG 1478Tyrphostin AG 1478SirolimusSirolimusMCL1MCL1PCNAPCNAPF-2341066PF-2341066cytarabine.hydrochloridecytarabine.hydrochlorideCBB1007CBB1007BexaroteneBexaroteneFOXM1FOXM1BI-2536BI-2536AZD-1775AZD-1775PaclitaxelPaclitaxelGSK-461364GSK-461364XL-880XL-880PF 184PF 184XPO1XPO1quinoclaminequinoclaminePertuzumabPertuzumabNeratinibNeratinibcytochalasin.Bcytochalasin.Blapatinib in HER2-amplifiedlapatinib in HER2-amplifiedEverolimusEverolimusDacomitinibDacomitinibAfatnibAfatnibFedratinibFedratinibERBB2 TKIsERBB2 TKIsNsc 632839Nsc 632839chemotherapychemotherapy179324-69-7179324-69-7Vorinostat (SAHA)Vorinostat (SAHA)BRD7137BRD7137PAC-1PAC-1Ado-trastuzumab emtansineAdo-trastuzumab emtansinetrastuzumab alonetrastuzumab aloneERBB2ERBB2MEK inhibitorsMEK inhibitorsSB225002SB225002BRD6368BRD6368avrainvillamideavrainvillamide(-)-gallocatechin-3-O-gallate(-)-gallocatechin-3-O-gallateoligomycin.Aoligomycin.ApevonedistatpevonedistatPI3K pathway inhibitorsPI3K pathway inhibitorsERBB3ERBB3BMS-754807BMS-754807AZD-8055AZD-8055SunitinibSunitinibAT 7867AT 7867BMS-345541BMS-345541AZD7762AZD7762nutlin 3nutlin 3CHM-1CHM-1UQCRC2UQCRC2nakiterpiosinnakiterpiosinNSC141540NSC141540VX-680VX-680FQI-2FQI-2MSH6MSH6ELCPKELCPKimportazoleimportazoletamatinibtamatinibBRD9876BRD9876NSC23766NSC237664-methylfasudil4-methylfasudilACVRL1ACVRL1leucascandrolide Aleucascandrolide ANPC26NPC26piperlonguminepiperlonguminePDGFRBPDGFRBTTF1TTF1KW-2449KW-2449

Models in KW-2449

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
EXP(HER2) protein MCLP BREAST undefined KW.2449 sensitivity in vitro
EXP(HER2_pY1248) protein MCLP BREAST undefined KW.2449 sensitivity in vitro
EXP(JAGGED1) protein MCLP BREAST undefined KW.2449 resistance in vitro
EXP(EGFR_pY1068) protein MCLP undefined PANCAN KW.2449 sensitivity in vitro
EXP(HER2) protein MCLP undefined PANCAN KW.2449 sensitivity in vitro
EXP(HER2_pY1248) protein MCLP undefined PANCAN KW.2449 sensitivity in vitro
EXP(HER3) protein MCLP undefined PANCAN KW.2449 sensitivity in vitro
EXP(PCNA) protein MCLP undefined PANCAN KW.2449 resistance in vitro
EXP(SMAD1) protein MCLP undefined PANCAN KW.2449 resistance in vitro
EXP(FOXM1) protein MCLP undefined PANCAN KW.2449 resistance in vitro
Showing 1 to 10 of 22 rows rows per page

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.