VDAC1
Summary: This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| voltage dependent anion channel 1 | MIM:604492 | Ensembl:ENSG00000213585 | HGNC:HGNC:12669 | PA37292 | 5q31.1 |
GO terms in VDAC1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0006820 | anion transport |
| BP | IDA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IEA | GO:0015698 | inorganic anion transport |
| BP | IEA | GO:0016032 | viral process |
| BP | TAS | GO:0016236 | macroautophagy |
| BP | IEP | GO:0030855 | epithelial cell differentiation |
| BP | IEA | GO:0098656 | anion transmembrane transport |
| BP | NAS | GO:1903146 | regulation of autophagy of mitochondrion |
| CC | HDA | GO:0005634 | nucleus |
| CC | HDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005741 | mitochondrial outer membrane |
| CC | TAS | GO:0005741 | mitochondrial outer membrane |
| CC | IDA | GO:0005757 | mitochondrial permeability transition pore complex |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | ISS | GO:0016020 | membrane |
| CC | IDA | GO:0042645 | mitochondrial nucleoid |
| CC | IEA | GO:0045121 | membrane raft |
| CC | TAS | GO:0046930 | pore complex |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008308 | voltage-gated anion channel activity |
| MF | ISS | GO:0008308 | voltage-gated anion channel activity |
| MF | IEA | GO:0015288 | porin activity |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0044325 | ion channel binding |
Gene expression in normal tissue: VDAC1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in VDAC1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04979 | Cholesterol metabolism - Homo sapiens (human) |
| kegg | hsa05012 | Parkinson,s disease - Homo sapiens (human) |
| kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| pharmgkb | PA165111376 | Benzodiazepine Pathway, Pharmacodynamics |
| reactome | R-HSA-1268020 | Mitochondrial protein import |
| reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5205647 | Mitophagy |
| reactome | R-HSA-5205685 | Pink/Parkin Mediated Mitophagy |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-70268 | Pyruvate metabolism |
| reactome | R-HSA-71406 | Pyruvate metabolism and Citric Acid (TCA) cycle |
| reactome | R-HSA-8949215 | Mitochondrial calcium ion transport |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD324 | CI-1040 | 1 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD150 | RITA | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD439 | KW-2449 | 1 |
| iGMDRD241 | Sunitinib | 1 |
| iGMDRD186 | SMER3 | 1 |
| iGMDRD551 | Ponatinib | 1 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD270 | Ciclosporin | 1 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD524 | ISX-9 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in VDAC1
CLASSFICATION
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