UQCRC2
Summary: The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ubiquinol-cytochrome c reductase core protein 2 | MIM:191329 | Ensembl:ENSG00000140740 | HGNC:HGNC:12586 | PA37217 | 16p12.2 |
GO terms in UQCRC2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006119 | oxidative phosphorylation |
| BP | IBA | GO:0006627 | protein processing involved in protein targeting to mitochondrion |
| BP | TAS | GO:0009060 | aerobic respiration |
| BP | IBA | GO:0016485 | protein processing |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | HDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IBA | GO:0005743 | mitochondrial inner membrane |
| CC | TAS | GO:0005743 | mitochondrial inner membrane |
| CC | IDA | GO:0005750 | mitochondrial respiratory chain complex III |
| CC | IDA | GO:0005751 | mitochondrial respiratory chain complex IV |
| CC | IEA | GO:0043209 | myelin sheath |
| MF | IBA | GO:0004222 | metalloendopeptidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0044877 | protein-containing complex binding |
Gene expression in normal tissue: UQCRC2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UQCRC2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-163200 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| reactome | R-HSA-611105 | Respiratory electron transport |
| wikipathways | WP111 | Electron Transport Chain |
| kegg | hsa00190 | Oxidative phosphorylation - Homo sapiens (human) |
| kegg | hsa04260 | Cardiac muscle contraction - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| kegg | hsa05012 | Parkinson,s disease - Homo sapiens (human) |
| kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD435 | BI-2536 | 1 |
| iGMDRD421 | AZD7762 | 1 |
| iGMDRD348 | BMS-345541 | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD594 | AZD-8055 | 1 |
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD241 | Sunitinib | 1 |
| iGMDRD423 | AT 7867 | 1 |
| iGMDRD439 | KW-2449 | 1 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD151 | CHM-1 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UQCRC2
CLASSFICATION
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