UQCRC2
Summary: The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:191329 Ensembl IDEnsembl:ENSG00000140740 HGNC IDHGNC:HGNC:12586 PHARMGKB IDPA37217 Map Location16p12.2 | |||||
GO terms in UQCRC2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006119 | oxidative phosphorylation |
| BP | IBA | GO:0006627 | protein processing involved in protein targeting to mitochondrion |
| BP | TAS | GO:0009060 | aerobic respiration |
| BP | IBA | GO:0016485 | protein processing |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | HDA | GO:0005739 | mitochondrion |
Gene expression in normal tissue: UQCRC2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in UQCRC2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-163200 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| reactome | R-HSA-611105 | Respiratory electron transport |
| wikipathways | WP111 | Electron Transport Chain |
| kegg | hsa00190 | Oxidative phosphorylation - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in UQCRC2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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