FOXM1
Summary: The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nameforkhead box M1 OMIM IDMIM:602341 Ensembl IDEnsembl:ENSG00000111206 HGNC IDHGNC:HGNC:3818 PHARMGKB IDPA28236 Map Location12p13.33 | |||||
GO terms in FOXM1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IC | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: FOXM1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FOXM1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | foxm1pathway | FOXM1 transcription factor network |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| reactome | R-HSA-156711 | Polo-like kinase mediated events |
| reactome | R-HSA-1640170 | Cell Cycle |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FOXM1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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