iGMDRD410

Canonical SMILES: CC(C)CC1C2=C(CC3N1C(=O)C(NC3=O)CCC(=O)OC(C)(C)C)C4=C(N2)C=C(C=C4)OC

InChI: InChI=1S/C26H35N3O5/c1-14(2)11-20-23-17(16-8-7-15(33-6)12-19(16)27-23)13-21-24(31)28-18(25(32)29(20)21)9-10-22(30)34-26(3,4)5/h7-8,12,14,18,20-21,27H,9-11,13H2,1-6H3,(H,28,31)/t18-,20-,21-/m0/s1

InChI Key: NXNRAECHCJZNRF-JBACZVJFSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameKo-143
Pubchem CID10322400
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

ABCG2

Drug-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 27LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 3PANCREAtissue: PANCREA cancer: PANCREAS model num: 0PANCREAStissue: PANCREAS cancer: undefined model num: 1LIVEtissue: LIVE cancer: LIVER model num: 0LIVERtissue: LIVER cancer: undefined model num: 1

Drug-gene pathway enrichments

13reactome: Signal Transduction8reactome: Disease6reactome: Gene expression (Transcription)5reactome: Diseases of signal transduction5reactome: Signaling by Receptor Tyrosine Kinases4reactome: Pre-NOTCH Expression and Processing4reactome: Generic Transcription Pathway4reactome: Pre-NOTCH Transcription and Translation4kegg: Pathways in cancer - Homo sapiens (human)4kegg: MAPK signaling pathway - Homo sapiens (human)

Drug-gene GO enrichments

15CC: plasma membrane13MF: protein binding10CC: nucleus9CC: cytosol7CC: nucleoplasm7BP: positive regulation of ERK1 and ERK2 cascade7MF: protein tyrosine kinase activity6MF: transmembrane receptor protein tyrosine kinase activity6CC: integral component of plasma membrane6BP: negative regulation of apoptotic process

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
10641 NPRL2 2
21 ABCA3 3
57580 PREX1 1
6598 SMARCB1 1
Showing 1 to 4 of 15 rows rows per page

Gene in drug-gene network: Network Plot

Models in Ko-143

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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