CUBN

Summary: Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecubilin
OMIM IDMIM:602997
Ensembl IDEnsembl:ENSG00000107611
HGNC IDHGNC:HGNC:2548
PHARMGKB IDPA27044
Map Location10p13

GO terms in CUBN


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0005215 transporter activity
MF IEA GO:0005509 calcium ion binding
MF IPI GO:0005515 protein binding
MF ISS GO:0008144 drug binding
MF IEA GO:0031419 cobalamin binding
MF TAS GO:0038023 signaling receptor activity
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Gene expression in normal tissue: CUBN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined33Apoptosis regulation2ERK MAPK signaling1Other, kinases1Stilbenoid, diarylheptanoid and gingerol biosynthesis1Chromatin histone acetylation1PI3K/MTOR signaling1

Pathways in CUBN


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1430728 Metabolism
reactome R-HSA-1643685 Disease
reactome R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance
reactome R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism
reactome R-HSA-196791 Vitamin D (calciferol) metabolism
reactome R-HSA-196849 Metabolism of water-soluble vitamins and cofactors
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD511 CHEMBL399379 2
iGMDRD123 Isoevodiamine 5
iGMDRD901 ELCPK 6
iGMDRD698 Neratinib 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CUBN

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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