CUBN


Summary: Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cubilinMIM:602997Ensembl:ENSG00000107611HGNC:HGNC:2548PA2704410p13

GO terms in CUBN


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0005215transporter activity
MFIEAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFISSGO:0008144drug binding
MFIEAGO:0031419cobalamin binding
MFTASGO:0038023signaling receptor activity
MFIDAGO:0042803protein homodimerization activity
BPNASGO:0001894tissue homeostasis
BPNASGO:0006898receptor-mediated endocytosis
BPIEAGO:0007165signal transduction
BPIEAGO:0008203cholesterol metabolic process
BPTASGO:0009235cobalamin metabolic process
BPTASGO:0015889cobalamin transport
BPTASGO:0034384high-density lipoprotein particle clearance
BPTASGO:0042359vitamin D metabolic process
BPIEAGO:0042953lipoprotein transport
CCIEAGO:0005765lysosomal membrane
CCIEAGO:0005783endoplasmic reticulum
CCIEAGO:0005794Golgi apparatus
CCTASGO:0005829cytosol
CCTASGO:0005886plasma membrane
CCIEAGO:0005905clathrin-coated pit
CCTASGO:0010008endosome membrane
CCTASGO:0016020membrane
CCIDAGO:0016324apical plasma membrane
CCISSGO:0016324apical plasma membrane
CCIDAGO:0030139endocytic vesicle
CCNASGO:0031232extrinsic component of external side of plasma membrane
CCISSGO:0031526brush border membrane
CCNASGO:0031526brush border membrane
CCTASGO:0043202lysosomal lumen
CCHDAGO:0070062extracellular exosome
CCIDAGO:0070062extracellular exosome

Gene expression in normal tissue: CUBN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CUBN


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1643685Disease
reactomeR-HSA-174824Plasma lipoprotein assembly, remodeling, and clearance
reactomeR-HSA-196741Cobalamin (Cbl, vitamin B12) transport and metabolism
reactomeR-HSA-196791Vitamin D (calciferol) metabolism
reactomeR-HSA-196849Metabolism of water-soluble vitamins and cofactors
reactomeR-HSA-196854Metabolism of vitamins and cofactors
reactomeR-HSA-3296469Defects in cobalamin (B12) metabolism
reactomeR-HSA-3296482Defects in vitamin and cofactor metabolism
reactomeR-HSA-3359462Defective AMN causes hereditary megaloblastic anemia 1
reactomeR-HSA-3359463Defective CUBN causes hereditary megaloblastic anemia 1
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-5668914Diseases of metabolism
reactomeR-HSA-8957322Metabolism of steroids
reactomeR-HSA-8964011HDL clearance
reactomeR-HSA-8964043Plasma lipoprotein clearance
wikipathwaysWP1533Vitamin B12 Metabolism
kegghsa04977Vitamin digestion and absorption - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD511CHEMBL3993792
iGMDRD123Isoevodiamine5
iGMDRD901ELCPK6
iGMDRD698Neratinib3
iGMDRD57Chloropentafluorobenzene2
iGMDRD341Triacsin c3
iGMDRD424Tamatinib3
iGMDRD150RITA2
iGMDRD410Ko-1433
iGMDRD84Lovastatin acid1
iGMDRD42Vorinostat5
iGMDRD505Pevonedistat2
iGMDRD329Merck6010
iGMDRD872BRD71378
iGMDRD871BRD63682
iGMDRD414MST-3122
iGMDRD67PENFLURIDOL2
iGMDRD77Itraconazole1
iGMDRD481Dactolisib4
iGMDRD434BMS-5369244
iGMDRD105Triptolide2
iGMDRD202Curcumin9
iGMDRD359OSW-15
iGMDRD280CYTOCHALASIN B8
iGMDRD679Bistramide A2
iGMDRD394BX-7953
iGMDRD61Kinetin riboside3
iGMDRD144NSC953972
iGMDRD1008SR-II-138A3
iGMDRD433Lexibulin4
iGMDRD151CHM-11
iGMDRD562Navitoclax3
iGMDRD506Fedratinib3
iGMDRD577BIX012942
iGMDRD399Selumetinib1
iGMDRD188Piperlongumine3
iGMDRD100Zebularine2
iGMDRD187BRD98763
iGMDRD318PAC-12
iGMDRD255SB2250022

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CUBN

​​​​