ABCA3


Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The full transporter encoded by this gene may be involved in development of resistance to xenobiotics and engulfment during programmed cell death. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ATP binding cassette subfamily A member 3MIM:601615Ensembl:ENSG00000167972HGNC:HGNC:33PA2437816p13.3

GO terms in ABCA3


Term TypeEvidence TypeGO Term IDGO Des.
CCHDAGO:0005615extracellular space
CCIDAGO:0005886plasma membrane
CCTASGO:0016020membrane
CCIEAGO:0016021integral component of membrane
CCIBAGO:0043231intracellular membrane-bounded organelle
CCIDAGO:0097208alveolar lamellar body
CCTASGO:0097232lamellar body membrane
CCIEAGO:0097233alveolar lamellar body membrane
BPIBAGO:0006869lipid transport
BPTASGO:0042493response to drug
BPTASGO:0044267cellular protein metabolic process
BPIEAGO:0051384response to glucocorticoid
BPTASGO:0055085transmembrane transport
MFTASGO:0005215transporter activity
MFTASGO:0005319lipid transporter activity
MFIEAGO:0005524ATP binding
MFIBAGO:0042626ATPase activity, coupled to transmembrane movement of substances
MFIEAGO:0042626ATPase activity, coupled to transmembrane movement of substances

Gene expression in normal tissue: ABCA3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ABCA3


DatabasePathway IDPathway Des.
reactomeR-HSA-1369062ABC transporters in lipid homeostasis
reactomeR-HSA-1643685Disease
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-382556ABC-family proteins mediated transport
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5619084ABC transporter disorders
reactomeR-HSA-5619115Disorders of transmembrane transporters
reactomeR-HSA-5668914Diseases of metabolism
reactomeR-HSA-5683678Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3)
reactomeR-HSA-5683826Surfactant metabolism
reactomeR-HSA-5687613Diseases associated with surfactant metabolism
reactomeR-HSA-5688399Defective ABCA3 causes pulmonary surfactant metabolism dysfunction 3 (SMDP3)
kegghsa02010ABC transporters - Homo sapiens (human)
pidera_genomic_pathwayValidated nuclear estrogen receptor alpha network

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD237ABT-7513
iGMDRD698Neratinib4
iGMDRD351GW843682X6
iGMDRD85Ursolic acid3
iGMDRD883CIL55A1
iGMDRD123Isoevodiamine5
iGMDRD901ELCPK3
iGMDRD248BRD43543
iGMDRD148Pifithrin-mu3
iGMDRD512nutlin 33
iGMDRD584VER 1550086
iGMDRD410Ko-1433
iGMDRD330BRD41321
iGMDRD84Lovastatin acid3
iGMDRD523Cyanoquinoline, 113
iGMDRD424Tamatinib9
iGMDRD882CIL413
iGMDRD871BRD63689
iGMDRD286Nsc 6328393
iGMDRD82Quiflapon1
iGMDRD246NPC263
iGMDRD300Tozasertib3
iGMDRD5Tyrphostin AG 14783
iGMDRD137Indisulam2
iGMDRD214AGK 22
iGMDRD77Itraconazole3
iGMDRD481Dactolisib3
iGMDRD434BMS-5369245
iGMDRD705Nakiterpiosin1
iGMDRD105Triptolide2
iGMDRD6AM-5804
iGMDRD394BX-7955
iGMDRD297Austocystin D2
iGMDRD599Salermide4
iGMDRD126Tipifarnib2
iGMDRD144NSC953973
iGMDRD427ABT7374
iGMDRD562Navitoclax3
iGMDRD780PP-302
iGMDRD506Fedratinib3
iGMDRD577BIX012943
iGMDRD888Compound 443
iGMDRD188Piperlongumine6
iGMDRD874BRD89583
iGMDRD60Quinoclamine3
iGMDRD369TGX-1153
iGMDRD613CHEMBL2581482
iGMDRD270Ciclosporin3
iGMDRD513BML-2591
iGMDRD294Batimastat1
iGMDRD52Rotenone3
iGMDRD226ML0063
iGMDRD318PAC-13
iGMDRD885Compound 1103
iGMDRD782DC-45-A23
iGMDRD207Capsaicin3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ABCA3

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