ABCA3
Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The full transporter encoded by this gene may be involved in development of resistance to xenobiotics and engulfment during programmed cell death. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ATP binding cassette subfamily A member 3 | MIM:601615 | Ensembl:ENSG00000167972 | HGNC:HGNC:33 | PA24378 | 16p13.3 |
GO terms in ABCA3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | HDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IDA | GO:0097208 | alveolar lamellar body |
| CC | TAS | GO:0097232 | lamellar body membrane |
| CC | IEA | GO:0097233 | alveolar lamellar body membrane |
| BP | IBA | GO:0006869 | lipid transport |
| BP | TAS | GO:0042493 | response to drug |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IEA | GO:0051384 | response to glucocorticoid |
| BP | TAS | GO:0055085 | transmembrane transport |
| MF | TAS | GO:0005215 | transporter activity |
| MF | TAS | GO:0005319 | lipid transporter activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances |
| MF | IEA | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances |
Gene expression in normal tissue: ABCA3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ABCA3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1369062 | ABC transporters in lipid homeostasis |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-382556 | ABC-family proteins mediated transport |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5619084 | ABC transporter disorders |
| reactome | R-HSA-5619115 | Disorders of transmembrane transporters |
| reactome | R-HSA-5668914 | Diseases of metabolism |
| reactome | R-HSA-5683678 | Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3) |
| reactome | R-HSA-5683826 | Surfactant metabolism |
| reactome | R-HSA-5687613 | Diseases associated with surfactant metabolism |
| reactome | R-HSA-5688399 | Defective ABCA3 causes pulmonary surfactant metabolism dysfunction 3 (SMDP3) |
| kegg | hsa02010 | ABC transporters - Homo sapiens (human) |
| pid | era_genomic_pathway | Validated nuclear estrogen receptor alpha network |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD698 | Neratinib | 4 |
| iGMDRD351 | GW843682X | 6 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD123 | Isoevodiamine | 5 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD248 | BRD4354 | 3 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD584 | VER 155008 | 6 |
| iGMDRD410 | Ko-143 | 3 |
| iGMDRD330 | BRD4132 | 1 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD424 | Tamatinib | 9 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD871 | BRD6368 | 9 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD214 | AGK 2 | 2 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD705 | Nakiterpiosin | 1 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD6 | AM-580 | 4 |
| iGMDRD394 | BX-795 | 5 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD599 | Salermide | 4 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD427 | ABT737 | 4 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD874 | BRD8958 | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD613 | CHEMBL258148 | 2 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD207 | Capsaicin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ABCA3
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