AMER1

Summary: The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). [provided by RefSeq, May 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameAPC membrane recruitment protein 1
OMIM IDMIM:300647
Ensembl IDEnsembl:ENSG00000184675
HGNC IDHGNC:HGNC:26837
PHARMGKB IDPA145148904
Map LocationXq11.2

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in AMER1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF IBA GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
MF IDA GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
MF IMP GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
MF IBA GO:0008013 beta-catenin binding
MF IDA GO:0008013 beta-catenin binding
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Gene expression in normal tissue: AMER1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined57Other, kinases3ERK MAPK signaling2PI3K/MTOR signaling2RTK signaling2DNA replication2Biosynthesis of secondary metabolites2Chromatin histone acetylation1Mitosis1Cytoskeleton1

Pathways in AMER1


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Database
Pathway ID
Pathway Des.
wikipathways WP2773 Degradation of beta-catenin by the destruction complex
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-1643685 Disease
reactome R-HSA-195253 Degradation of beta-catenin by the destruction complex
reactome R-HSA-195721 Signaling by WNT
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD474 Avrainvillamide 5
iGMDRD260 FQI-2 2
iGMDRD52 Rotenone 7
iGMDRD187 BRD9876 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AMER1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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