AMER1
Summary: The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). [provided by RefSeq, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| APC membrane recruitment protein 1 | MIM:300647 | Ensembl:ENSG00000184675 | HGNC:HGNC:26837 | PA145148904 | Xq11.2 |
Gene Categories:
CLINICALLY ACTIONABLEGO terms in AMER1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| MF | IDA | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| MF | IMP | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| MF | IBA | GO:0008013 | beta-catenin binding |
| MF | IDA | GO:0008013 | beta-catenin binding |
| MF | IPI | GO:0008013 | beta-catenin binding |
| MF | IPI | GO:1904713 | beta-catenin destruction complex binding |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| BP | TAS | GO:0016055 | Wnt signaling pathway |
| BP | IDA | GO:0031398 | positive regulation of protein ubiquitination |
| BP | IBA | GO:0048856 | anatomical structure development |
| BP | IEA | GO:0060348 | bone development |
| BP | IEA | GO:0060612 | adipose tissue development |
| BP | IBA | GO:0060828 | regulation of canonical Wnt signaling pathway |
| BP | IMP | GO:0060828 | regulation of canonical Wnt signaling pathway |
| BP | IEA | GO:0072161 | mesenchymal cell differentiation involved in kidney development |
| BP | IGI | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IMP | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IMP | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | IDA | GO:1903364 | positive regulation of cellular protein catabolic process |
| BP | TAS | GO:1904885 | beta-catenin destruction complex assembly |
| BP | TAS | GO:1904886 | beta-catenin destruction complex disassembly |
Gene expression in normal tissue: AMER1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AMER1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2773 | Degradation of beta-catenin by the destruction complex |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-195253 | Degradation of beta-catenin by the destruction complex |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-196299 | Beta-catenin phosphorylation cascade |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| reactome | R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| reactome | R-HSA-4791275 | Signaling by WNT in cancer |
| reactome | R-HSA-4839735 | AXIN mutants destabilize the destruction complex, activating WNT signaling |
| reactome | R-HSA-4839743 | phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex |
| reactome | R-HSA-4839744 | truncated APC mutants destabilize the destruction complex |
| reactome | R-HSA-4839748 | AMER1 mutants destabilize the destruction complex |
| reactome | R-HSA-5339716 | Misspliced GSK3beta mutants stabilize beta-catenin |
| reactome | R-HSA-5358747 | S33 mutants of beta-catenin aren't phosphorylated |
| reactome | R-HSA-5358749 | S37 mutants of beta-catenin aren't phosphorylated |
| reactome | R-HSA-5358751 | S45 mutants of beta-catenin aren't phosphorylated |
| reactome | R-HSA-5358752 | T41 mutants of beta-catenin aren't phosphorylated |
| reactome | R-HSA-5467337 | APC truncation mutants have impaired AXIN binding |
| reactome | R-HSA-5467340 | AXIN missense mutants destabilize the destruction complex |
| reactome | R-HSA-5467348 | Truncations of AMER1 destabilize the destruction complex |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD474 | Avrainvillamide | 5 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD52 | Rotenone | 7 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD888 | Compound 44 | 6 |
| iGMDRD190 | Nilotinib | 1 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD23 | Gossypol | 8 |
| iGMDRD524 | ISX-9 | 6 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD749 | ZINC6718453 | 1 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD781 | Sirolimus | 11 |
| iGMDRD397 | Pazopanib | 1 |
| iGMDRD2 | PK-11195 | 1 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD470 | Trametinib | 1 |
| iGMDRD103 | SN-38 | 6 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD158 | NSC141540 | 4 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD705 | Nakiterpiosin | 5 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD662 | JQ-1 | 1 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD330 | BRD4132 | 5 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD523 | Cyanoquinoline, 11 | 4 |
| iGMDRD219 | Bax channel blocker | 2 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD802 | 4-methylfasudil | 1 |
| iGMDRD782 | DC-45-A2 | 5 |
| iGMDRD318 | PAC-1 | 8 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD371 | THR1 Inhibitor | 1 |
| iGMDRD630 | ML203 | 2 |
| iGMDRD554 | CHEMBL1434137 | 4 |
| iGMDRD599 | Salermide | 4 |
| iGMDRD579 | PF750 | 1 |
| iGMDRD678 | Tubastatin A | 1 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD686 | PF4708671 | 1 |
| iGMDRD498 | GW441756X | 1 |
| iGMDRD797 | ISOX DUAL | 1 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD359 | OSW-1 | 1 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD267 | Oligomycin A | 7 |
| iGMDRD269 | Purmorphamine | 2 |
| iGMDRD191 | FMK | 1 |
| iGMDRD505 | Pevonedistat | 4 |
| iGMDRD886 | Compound 1541A | 9 |
| iGMDRD300 | Tozasertib | 7 |
| iGMDRD82 | Quiflapon | 8 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD347 | Y-39983 | 1 |
| iGMDRD410 | Ko-143 | 2 |
| iGMDRD720 | 844499-71-4 | 1 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD435 | BI-2536 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AMER1
CLASSFICATION
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