AMER1


Summary: The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). [provided by RefSeq, May 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
APC membrane recruitment protein 1MIM:300647Ensembl:ENSG00000184675HGNC:HGNC:26837PA145148904Xq11.2

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in AMER1


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIBAGO:0005546phosphatidylinositol-4,5-bisphosphate binding
MFIDAGO:0005546phosphatidylinositol-4,5-bisphosphate binding
MFIMPGO:0005546phosphatidylinositol-4,5-bisphosphate binding
MFIBAGO:0008013beta-catenin binding
MFIDAGO:0008013beta-catenin binding
MFIPIGO:0008013beta-catenin binding
MFIPIGO:1904713beta-catenin destruction complex binding
CCTASGO:0005829cytosol
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCIDAGO:0016604nuclear body
CCIDAGO:0043231intracellular membrane-bounded organelle
BPTASGO:0016055Wnt signaling pathway
BPIDAGO:0031398positive regulation of protein ubiquitination
BPIBAGO:0048856anatomical structure development
BPIEAGO:0060348bone development
BPIEAGO:0060612adipose tissue development
BPIBAGO:0060828regulation of canonical Wnt signaling pathway
BPIMPGO:0060828regulation of canonical Wnt signaling pathway
BPIEAGO:0072161mesenchymal cell differentiation involved in kidney development
BPIGIGO:0090090negative regulation of canonical Wnt signaling pathway
BPIMPGO:0090090negative regulation of canonical Wnt signaling pathway
BPIMPGO:0090263positive regulation of canonical Wnt signaling pathway
BPIDAGO:1903364positive regulation of cellular protein catabolic process
BPTASGO:1904885beta-catenin destruction complex assembly
BPTASGO:1904886beta-catenin destruction complex disassembly

Gene expression in normal tissue: AMER1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AMER1


DatabasePathway IDPathway Des.
wikipathwaysWP2773Degradation of beta-catenin by the destruction complex
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-195253Degradation of beta-catenin by the destruction complex
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-196299Beta-catenin phosphorylation cascade
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membrane
reactomeR-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membrane
reactomeR-HSA-4791275Signaling by WNT in cancer
reactomeR-HSA-4839735AXIN mutants destabilize the destruction complex, activating WNT signaling
reactomeR-HSA-4839743phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
reactomeR-HSA-4839744truncated APC mutants destabilize the destruction complex
reactomeR-HSA-4839748AMER1 mutants destabilize the destruction complex
reactomeR-HSA-5339716Misspliced GSK3beta mutants stabilize beta-catenin
reactomeR-HSA-5358747S33 mutants of beta-catenin aren't phosphorylated
reactomeR-HSA-5358749S37 mutants of beta-catenin aren't phosphorylated
reactomeR-HSA-5358751S45 mutants of beta-catenin aren't phosphorylated
reactomeR-HSA-5358752T41 mutants of beta-catenin aren't phosphorylated
reactomeR-HSA-5467337APC truncation mutants have impaired AXIN binding
reactomeR-HSA-5467340AXIN missense mutants destabilize the destruction complex
reactomeR-HSA-5467348Truncations of AMER1 destabilize the destruction complex
reactomeR-HSA-5663202Diseases of signal transduction

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD474Avrainvillamide5
iGMDRD260FQI-22
iGMDRD52Rotenone7
iGMDRD187BRD98761
iGMDRD506Fedratinib5
iGMDRD888Compound 446
iGMDRD190Nilotinib1
iGMDRD356PNU-746542
iGMDRD23Gossypol8
iGMDRD524ISX-96
iGMDRD151CHM-14
iGMDRD749ZINC67184531
iGMDRD420Leucascandrolide A3
iGMDRD546BMS-7548071
iGMDRD781Sirolimus11
iGMDRD397Pazopanib1
iGMDRD2PK-111951
iGMDRD152179324-69-71
iGMDRD470Trametinib1
iGMDRD103SN-386
iGMDRD137Indisulam4
iGMDRD121GMX17783
iGMDRD158NSC1415404
iGMDRD105Triptolide2
iGMDRD705Nakiterpiosin5
iGMDRD871BRD63682
iGMDRD367Ro 28-16752
iGMDRD662JQ-11
iGMDRD147Prima-12
iGMDRD322FK 8663
iGMDRD330BRD41325
iGMDRD584VER 1550082
iGMDRD523Cyanoquinoline, 114
iGMDRD219Bax channel blocker2
iGMDRD237ABT-7512
iGMDRD123Isoevodiamine3
iGMDRD154NSC237661
iGMDRD255SB2250022
iGMDRD8024-methylfasudil1
iGMDRD782DC-45-A25
iGMDRD318PAC-18
iGMDRD870BRD636101
iGMDRD30917AAG1
iGMDRD887Compound 23 citrate3
iGMDRD577BIX012942
iGMDRD60Quinoclamine4
iGMDRD268Cerulenin2
iGMDRD371THR1 Inhibitor1
iGMDRD630ML2032
iGMDRD554CHEMBL14341374
iGMDRD599Salermide4
iGMDRD579PF7501
iGMDRD678Tubastatin A1
iGMDRD494Neopeltolide3
iGMDRD446LY 21832401
iGMDRD686PF47086711
iGMDRD498GW441756X1
iGMDRD797ISOX DUAL1
iGMDRD201SKI II1
iGMDRD193Fqi12
iGMDRD359OSW-11
iGMDRD6AM-5803
iGMDRD434BMS-5369242
iGMDRD481Dactolisib1
iGMDRD267Oligomycin A7
iGMDRD269Purmorphamine2
iGMDRD191FMK1
iGMDRD505Pevonedistat4
iGMDRD886Compound 1541A9
iGMDRD300Tozasertib7
iGMDRD82Quiflapon8
iGMDRD307Manumycin A1
iGMDRD512nutlin 32
iGMDRD347Y-399831
iGMDRD410Ko-1432
iGMDRD720844499-71-41
iGMDRD424Tamatinib1
iGMDRD536PLX-47201
iGMDRD901ELCPK1
iGMDRD177Teniposide2
iGMDRD132(-)-gallocatechin-3-O-gallate1
iGMDRD435BI-25362

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AMER1

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