iGMDRD191

Canonical SMILES: CC1=CC=C(C=C1)C2=C(N(C3=C2C(=NC=N3)N)CCCO)C(=O)CF

InChI: InChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22)

InChI Key: IKLGYJACVCXYIL-UHFFFAOYSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameFMK
Pubchem CID644243
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

RSK

Drug Pathways:

Other, kinases

Drug-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2LYMPtissue: LYMP cancer: LYMPH model num: 0LYMPHtissue: LYMPH cancer: Diffuse Large B-Cell Lymphoma (DLBCL) model num: 1BONtissue: BON cancer: BONE model num: 0BONEtissue: BONE cancer: Acute Myeloid Leukemia (AML) model num: 1PANCREAtissue: PANCREA cancer: PANCREAS model num: 0PANCREAStissue: PANCREAS cancer: Pancreatic Adenocarcinoma (PAAD) model num: 1SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Cutaneous Melanoma (SKCM) model num: 1

Drug-gene pathway enrichments

8reactome: Signal Transduction4reactome: Disease4reactome: RNA Polymerase II Transcription4reactome: Gene expression (Transcription)4reactome: Diseases of signal transduction4reactome: Generic Transcription Pathway3kegg: FoxO signaling pathway - Homo sapiens (human)3wikipathways: Signaling Pathways in Glioblastoma3reactome: Developmental Biology3reactome: Signaling by WNT

Drug-gene GO enrichments

7MF: protein binding5CC: nucleoplasm5CC: nucleus5CC: cytosol4CC: cytoplasm4MF: beta-catenin binding4CC: plasma membrane3MF: DNA binding3MF: protein serine/threonine kinase activity3MF: transcription coactivator activity

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
8289 ARID1A 1
2033 EP300 2
256646 NUTM1 1
139285 AMER1 1
Showing 1 to 4 of 7 rows

Gene in drug-gene network: Network Plot

Models in FMK

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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