TAOK1
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TAO kinase 1 | MIM:610266 | Ensembl:ENSG00000160551 | HGNC:HGNC:29259 | PA134872946 | 17q11.2 |
GO terms in TAOK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IMP | GO:0015630 | microtubule cytoskeleton |
| CC | IMP | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IBA | GO:0000186 | activation of MAPKK activity |
| BP | IEA | GO:0000186 | activation of MAPKK activity |
| BP | TAS | GO:0000187 | activation of MAPK activity |
| BP | IMP | GO:0000226 | microtubule cytoskeleton organization |
| BP | IEA | GO:0006281 | DNA repair |
| BP | NAS | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IMP | GO:0007026 | negative regulation of microtubule depolymerization |
| BP | IMP | GO:0007095 | mitotic G2 DNA damage checkpoint |
| BP | TAS | GO:0007257 | activation of JUN kinase activity |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IMP | GO:0032874 | positive regulation of stress-activated MAPK cascade |
| BP | ISS | GO:0032956 | regulation of actin cytoskeleton organization |
| BP | IDA | GO:0046330 | positive regulation of JNK cascade |
| BP | ISS | GO:0046777 | protein autophosphorylation |
| BP | ISS | GO:0051493 | regulation of cytoskeleton organization |
| BP | IMP | GO:0070050 | neuron cellular homeostasis |
| BP | ISS | GO:0070507 | regulation of microtubule cytoskeleton organization |
| BP | IBA | GO:0097194 | execution phase of apoptosis |
| BP | IDA | GO:0097194 | execution phase of apoptosis |
| BP | IMP | GO:1901985 | positive regulation of protein acetylation |
| MF | ISS | GO:0004672 | protein kinase activity |
| MF | NAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | NAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0005524 | ATP binding |
| MF | IDA | GO:0016301 | kinase activity |
| MF | NAS | GO:0016301 | kinase activity |
| MF | NAS | GO:0016740 | transferase activity |
| MF | IDA | GO:0043014 | alpha-tubulin binding |
| MF | ISS | GO:0043539 | protein serine/threonine kinase activator activity |
| MF | IDA | GO:0048487 | beta-tubulin binding |
Gene expression in normal tissue: TAOK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TAOK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2038 | Regulation of Microtubule Cytoskeleton |
| wikipathways | WP382 | MAPK Signaling Pathway |
| pid | p38_mkk3_6pathway | p38 MAPK signaling pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| reactome | R-HSA-141424 | Amplification of signal from the kinetochores |
| reactome | R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69618 | Mitotic Spindle Checkpoint |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD705 | Nakiterpiosin | 6 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD191 | FMK | 1 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD398 | Sepantronium | 5 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD872 | BRD7137 | 1 |
| iGMDRD483 | SCH-529074 | 1 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD280 | CYTOCHALASIN B | 8 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD341 | Triacsin c | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TAOK1
CLASSFICATION
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