NPRL2
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| NPR2 like, GATOR1 complex subunit | MIM:607072 | Ensembl:ENSG00000114388 | HGNC:HGNC:24969 | PA165697981 | 3p21.31 |
Gene Categories:
KINASEGO terms in NPRL2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0006995 | cellular response to nitrogen starvation |
| BP | IBA | GO:0010508 | positive regulation of autophagy |
| BP | IBA | GO:0032007 | negative regulation of TOR signaling |
| BP | IMP | GO:0032007 | negative regulation of TOR signaling |
| BP | IDA | GO:0033673 | negative regulation of kinase activity |
| BP | IBA | GO:0034198 | cellular response to amino acid starvation |
| BP | IMP | GO:0034198 | cellular response to amino acid starvation |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | IBA | GO:2000785 | regulation of autophagosome assembly |
| CC | IDA | GO:0005765 | lysosomal membrane |
| CC | IBA | GO:0005773 | vacuole |
| CC | IBA | GO:1990130 | GATOR1 complex |
| CC | IDA | GO:1990130 | GATOR1 complex |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IDA | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: NPRL2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NPRL2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD246 | NPC26 | 1 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD42 | Vorinostat | 5 |
| iGMDRD410 | Ko-143 | 2 |
| iGMDRD47 | ZM336372 | 3 |
| iGMDRD701 | NVP-AUY922 | 6 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD154 | NSC23766 | 6 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD74 | Idarubicin | 1 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD577 | BIX01294 | 1 |
| iGMDRD451 | Serdemetan | 1 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD126 | Tipifarnib | 6 |
| iGMDRD420 | Leucascandrolide A | 1 |
| iGMDRD889 | Compound 7d-cis | 1 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD144 | NSC95397 | 4 |
| iGMDRD71 | Sparfosic acid | 1 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD375 | GW-405833 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NPRL2
CLASSFICATION
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