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KIT

Summary: This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameKIT proto-oncogene receptor tyrosine kinase OMIM IDMIM:164920 Ensembl IDEnsembl:ENSG00000157404 HGNC IDHGNC:HGNC:6342 PHARMGKB IDPA30128 Map Location4q12

Gene Categories:

DRUGGABLE GENOME PHOSPHOLIPASE EXTERNAL SIDE OF PLASMA MEMBRANE SERINE THREONINE KINASE LIPID KINASE TYROSINE KINASE CLINICALLY ACTIONABLE CELL SURFACE KINASE

GO terms in KIT

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	TAS	GO:0000165	MAPK cascade
BP	IDA	GO:0000187	activation of MAPK activity
BP	ISS	GO:0001541	ovarian follicle development
BP	IEA	GO:0002318	myeloid progenitor cell differentiation
BP	IEA	GO:0002320	lymphoid progenitor cell differentiation
BP	ISS	GO:0002327	immature B cell differentiation

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Gene expression in normal tissue: KIT

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KIT

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Database	Pathway ID	Pathway Des.
pid	cmyb_pathway	C-MYB transcription factor network
pid	kitpathway	Signaling events mediated by Stem cell factor receptor (c-Kit)
pharmgkb	PA164713427	Imatinib Pathway, Pharmacokinetics/Pharmacodynamics
pharmgkb	PA165959425	Pathway_PA165959425
pharmgkb	PA165959584	Sorafenib Pharmacodynamics
netpath	Pathway_EGFR1	EGFR1

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD193	Fqi1	3
iGMDRD152	179324-69-7	4
iGMDRD61	Kinetin riboside	2
iGMDRD446	LY 2183240	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KIT

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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