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iGMDRD273

Canonical SMILES: CN1CCC(C(C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O

InChI: InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1

InChI Key: BIIVYFLTOXDAOV-YVEFUNNKSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug targets (TTD)	Drug Type
Alvocidib	CHEMBL428690	5287970	DB03496	Alone	DCL000422	Small Molecule

Drug Class:

Antineoplastic Agents BCRP/ABCG2 Substrates Benzopyrans Chromones Cyclin-Dependent Kinases, antagonists & inhibitors Enzyme Inhibitors Growth Inhibitors Growth Substances Heterocyclic Compounds Heterocyclic Compounds, 1-Ring Heterocyclic Compounds, 2-Ring Protein Kinase Inhibitors Pyrans UGT1A1 Substrates

Drug Targets:

CDK2 (P24941)CDK5 (Q00535)CDK9 (P50750)CDK1 (P06493)CDK6 (Q00534)EGFR (P00533)CDK4 (P11802)CDK8 (P49336)CDK7 (P50613)PYGM (P11217)PYGB (P11216)PYGL (P06737)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
7514	XPO1	1
2956	MSH6	1
4170	MCL1	1
2625	GATA3	1
6714	SRC	1
3791	KDR	1
4086	SMAD1	1
9223	MAGI1	1

Gene in drug-gene network: Network Plot

Models in Alvocidib

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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.