SRC
Summary: This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SRC proto-oncogene, non-receptor tyrosine kinase | MIM:190090 | Ensembl:ENSG00000197122 | HGNC:HGNC:11283 | PA36111 | 20q11.23 |
GO terms in SRC
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0002102 | podosome |
| CC | IEA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005743 | mitochondrial inner membrane |
| CC | IDA | GO:0005764 | lysosome |
| CC | IDA | GO:0005770 | late endosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005884 | actin filament |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005901 | caveola |
| CC | IEA | GO:0014069 | postsynaptic density |
| CC | IBA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| CC | IEA | GO:0032587 | ruffle membrane |
| CC | IEA | GO:0043005 | neuron projection |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0001545 | primary ovarian follicle growth |
| BP | TAS | GO:0002223 | stimulatory C-type lectin receptor signaling pathway |
| BP | IEA | GO:0007049 | cell cycle |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | TAS | GO:0007172 | signal complex assembly |
| BP | IBA | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | TAS | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | IMP | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | IMP | GO:0007229 | integrin-mediated signaling pathway |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IEA | GO:0008283 | cell proliferation |
| BP | IEA | GO:0009612 | response to mechanical stimulus |
| BP | IEA | GO:0009615 | response to virus |
| BP | IEA | GO:0010447 | response to acidic pH |
| BP | IMP | GO:0010632 | regulation of epithelial cell migration |
| BP | IMP | GO:0010634 | positive regulation of epithelial cell migration |
| BP | IEA | GO:0010641 | positive regulation of platelet-derived growth factor receptor signaling pathway |
| BP | IEA | GO:0010907 | positive regulation of glucose metabolic process |
| BP | IEA | GO:0010954 | positive regulation of protein processing |
| BP | IEA | GO:0014911 | positive regulation of smooth muscle cell migration |
| BP | IEA | GO:0016032 | viral process |
| BP | TAS | GO:0016236 | macroautophagy |
| BP | IEA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IMP | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IMP | GO:0022407 | regulation of cell-cell adhesion |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | TAS | GO:0030168 | platelet activation |
| BP | IEA | GO:0030900 | forebrain development |
| BP | TAS | GO:0031295 | T cell costimulation |
| BP | IEA | GO:0031648 | protein destabilization |
| BP | IEA | GO:0031667 | response to nutrient levels |
| BP | IEA | GO:0031954 | positive regulation of protein autophosphorylation |
| BP | IEA | GO:0032148 | activation of protein kinase B activity |
| BP | IMP | GO:0032211 | negative regulation of telomere maintenance via telomerase |
| BP | IMP | GO:0032463 | negative regulation of protein homooligomerization |
| BP | IEA | GO:0032869 | cellular response to insulin stimulus |
| BP | IEA | GO:0033146 | regulation of intracellular estrogen receptor signaling pathway |
| BP | TAS | GO:0033625 | positive regulation of integrin activation |
| BP | IEA | GO:0034332 | adherens junction organization |
| BP | IEA | GO:0034446 | substrate adhesion-dependent cell spreading |
| BP | IEA | GO:0034614 | cellular response to reactive oxygen species |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0035635 | entry of bacterium into host cell |
| BP | IBA | GO:0036035 | osteoclast development |
| BP | IEA | GO:0036120 | cellular response to platelet-derived growth factor stimulus |
| BP | IBA | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | IBA | GO:0042127 | regulation of cell proliferation |
| BP | IEA | GO:0042542 | response to hydrogen peroxide |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0043114 | regulation of vascular permeability |
| BP | IMP | GO:0043149 | stress fiber assembly |
| BP | IMP | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IEA | GO:0043393 | regulation of protein binding |
| BP | IEA | GO:0043406 | positive regulation of MAP kinase activity |
| BP | IEA | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity |
| BP | IEA | GO:0045056 | transcytosis |
| BP | IBA | GO:0045087 | innate immune response |
| BP | TAS | GO:0045124 | regulation of bone resorption |
| BP | IBA | GO:0045453 | bone resorption |
| BP | ISS | GO:0045453 | bone resorption |
| BP | IEA | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IEA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IEA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0046628 | positive regulation of insulin receptor signaling pathway |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | IEA | GO:0048011 | neurotrophin TRK receptor signaling pathway |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | IEA | GO:0048477 | oogenesis |
| BP | IEA | GO:0050715 | positive regulation of cytokine secretion |
| BP | IC | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0050847 | progesterone receptor signaling pathway |
| BP | ISS | GO:0050847 | progesterone receptor signaling pathway |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IMP | GO:0051057 | positive regulation of small GTPase mediated signal transduction |
| BP | IEA | GO:0051385 | response to mineralocorticoid |
| BP | IEA | GO:0051602 | response to electrical stimulus |
| BP | ISS | GO:0051895 | negative regulation of focal adhesion assembly |
| BP | IMP | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IMP | GO:0051902 | negative regulation of mitochondrial depolarization |
| BP | IMP | GO:0051974 | negative regulation of telomerase activity |
| BP | IEA | GO:0060065 | uterus development |
| BP | IEA | GO:0060444 | branching involved in mammary gland duct morphogenesis |
| BP | IEA | GO:0060491 | regulation of cell projection assembly |
| BP | IEA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:0070555 | response to interleukin-1 |
| BP | IEA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | ISS | GO:0071375 | cellular response to peptide hormone stimulus |
| BP | ISS | GO:0071393 | cellular response to progesterone stimulus |
| BP | IEA | GO:0071398 | cellular response to fatty acid |
| BP | IEA | GO:0071456 | cellular response to hypoxia |
| BP | IEA | GO:0071498 | cellular response to fluid shear stress |
| BP | IEA | GO:0071803 | positive regulation of podosome assembly |
| BP | IDA | GO:0071902 | positive regulation of protein serine/threonine kinase activity |
| BP | ISS | GO:0086098 | angiotensin-activated signaling pathway involved in heart process |
| BP | IEA | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | IEA | GO:0098609 | cell-cell adhesion |
| BP | IEA | GO:1900182 | positive regulation of protein localization to nucleus |
| BP | IEA | GO:2000386 | positive regulation of ovarian follicle development |
| BP | IMP | GO:2000394 | positive regulation of lamellipodium morphogenesis |
| BP | IEA | GO:2000573 | positive regulation of DNA biosynthetic process |
| BP | IMP | GO:2000641 | regulation of early endosome to late endosome transport |
| BP | IMP | GO:2000811 | negative regulation of anoikis |
| BP | IBA | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| BP | IMP | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| BP | IBA | GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway |
| BP | IMP | GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway |
| BP | IMP | GO:2001286 | regulation of caveolin-mediated endocytosis |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | EXP | GO:0004713 | protein tyrosine kinase activity |
| MF | IDA | GO:0004713 | protein tyrosine kinase activity |
| MF | IMP | GO:0004713 | protein tyrosine kinase activity |
| MF | NAS | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | TAS | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | TAS | GO:0005070 | SH3/SH2 adaptor activity |
| MF | IEA | GO:0005080 | protein kinase C binding |
| MF | IBA | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005102 | signaling receptor binding |
| MF | IEA | GO:0005158 | insulin receptor binding |
| MF | TAS | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0008022 | protein C-terminus binding |
| MF | TAS | GO:0016301 | kinase activity |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0019900 | kinase binding |
| MF | IDA | GO:0020037 | heme binding |
| MF | IEA | GO:0030331 | estrogen receptor binding |
| MF | IEA | GO:0031625 | ubiquitin protein ligase binding |
| MF | IPI | GO:0042169 | SH2 domain binding |
| MF | IPI | GO:0044325 | ion channel binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IPI | GO:0046875 | ephrin receptor binding |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| MF | IPI | GO:0051219 | phosphoprotein binding |
| MF | IBA | GO:0051427 | hormone receptor binding |
| MF | IBA | GO:0070851 | growth factor receptor binding |
| MF | IPI | GO:0070851 | growth factor receptor binding |
| MF | IEA | GO:0071253 | connexin binding |
| MF | IPI | GO:0097110 | scaffold protein binding |
Gene expression in normal tissue: SRC
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SRC
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
| pid | alphasynuclein_pathway | Alpha-synuclein signaling |
| pid | ar_nongenomic_pathway | Nongenotropic Androgen signaling |
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| pid | arf6_pathway | Arf6 signaling events |
| pid | avb3_integrin_pathway | Integrins in angiogenesis |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | cxcr3pathway | CXCR3-mediated signaling events |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | ecadherin_keratinocyte_pathway | E-cadherin signaling in keratinocytes |
| pid | ecadherin_nascentaj_pathway | E-cadherin signaling in the nascent adherens junction |
| pid | endothelinpathway | Endothelins |
| pid | epha2_fwdpathway | EPHA2 forward signaling |
| pid | epha_fwdpathway | EPHA forward signaling |
| pid | ephbfwdpathway | EPHB forward signaling |
| pid | ephrinbrevpathway | Ephrin B reverse signaling |
| pid | er_nongenomic_pathway | Plasma membrane estrogen receptor signaling |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | erbb1_internalization_pathway | Internalization of ErbB1 |
| pid | erbb2erbb3pathway | ErbB2/ErbB3 signaling events |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | faspathway | FAS (CD95) signaling pathway |
| pid | fgf_pathway | FGF signaling pathway |
| pid | glypican_1pathway | Glypican 1 network |
| pid | integrin_a4b1_pathway | Alpha4 beta1 integrin signaling events |
| pid | integrin_a9b1_pathway | Alpha9 beta1 integrin signaling events |
| pid | lysophospholipid_pathway | LPA receptor mediated events |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | nectin_pathway | Nectin adhesion pathway |
| pid | netrin_pathway | Netrin-mediated signaling events |
| pid | nfkappabatypicalpathway | Atypical NF-kappaB pathway |
| pid | p38alphabetapathway | Regulation of p38-alpha and p38-beta |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | pi3kciaktpathway | Class I PI3K signaling events mediated by Akt |
| pid | pi3kcipathway | Class I PI3K signaling events |
| pid | pi3kplctrkpathway | Trk receptor signaling mediated by PI3K and PLC-gamma |
| pid | prlsignalingeventspathway | Signaling events mediated by PRL |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| pid | ret_pathway | Signaling events regulated by Ret tyrosine kinase |
| pid | s1p_s1p3_pathway | S1P3 pathway |
| pid | syndecan_2_pathway | Syndecan-2-mediated signaling events |
| pid | syndecan_3_pathway | Syndecan-3-mediated signaling events |
| pid | tcptp_pathway | Signaling events mediated by TCPTP |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| pid | upa_upar_pathway | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| netpath | Pathway_Ghrelin | Ghrelin |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_Notch | Notch |
| netpath | Pathway_Oncostatin_M | Oncostatin_M |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_TCR | TCR |
| netpath | Pathway_TNFalpha | TNFalpha |
| pharmgkb | PA2024 | Beta-agonist/Beta-blocker Pathway, Pharmacodynamics |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04137 | Mitophagy - animal - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04727 | GABAergic synapse - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
| kegg | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| kegg | hsa05131 | Shigellosis - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05219 | Bladder cancer - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP1539 | Angiogenesis |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP1993 | Angiogenesis overview |
| wikipathways | WP2018 | RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2035 | Follicle Stimulating Hormone (FSH) signaling pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP2038 | Regulation of Microtubule Cytoskeleton |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP244 | Alpha 6 Beta 4 signaling pathway |
| wikipathways | WP2512 | Integrated Lung Cancer Pathway |
| wikipathways | WP2571 | Polycystic Kidney Disease Pathway |
| wikipathways | WP2586 | Aryl Hydrocarbon Receptor |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP2873 | Aryl Hydrocarbon Receptor Pathway |
| wikipathways | WP2876 | Pregnane X Receptor pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP313 | Signaling of Hepatocyte Growth Factor Receptor |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3678 | Amplification and Expansion of Oncogenic Pathways as Metastatic Traits |
| wikipathways | WP3680 | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3943 | Robo4 and VEGF Signaling Pathways Crosstalk |
| wikipathways | WP4010 | Liver steatosis AOP |
| wikipathways | WP4136 | Fibrin Complement Receptor 3 Signaling Pathway |
| wikipathways | WP4205 | MET in type 1 papillary renal cell carcinoma |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP581 | EPO Receptor Signaling |
| wikipathways | WP61 | Notch Signaling Pathway |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| wikipathways | WP673 | ErbB Signaling Pathway |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1295596 | Spry regulation of FGF signaling |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-1433559 | Regulation of KIT signaling |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-157858 | Gap junction trafficking and regulation |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-167044 | Signalling to RAS |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-171007 | p38MAPK events |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-180292 | GAB1 signalosome |
| reactome | R-HSA-186763 | Downstream signal transduction |
| reactome | R-HSA-186797 | Signaling by PDGF |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187687 | Signalling to ERKs |
| reactome | R-HSA-190236 | Signaling by FGFR |
| reactome | R-HSA-191647 | c-src mediated regulation of Cx43 function and closure of gap junctions |
| reactome | R-HSA-191650 | Regulation of gap junction activity |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029481 | FCGR activation |
| reactome | R-HSA-210990 | PECAM1 interactions |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-354192 | Integrin alphaIIb beta3 signaling |
| reactome | R-HSA-354194 | GRB2:SOS provides linkage to MAPK signaling for Integrins |
| reactome | R-HSA-372708 | p130Cas linkage to MAPK signaling for integrins |
| reactome | R-HSA-373752 | Netrin-1 signaling |
| reactome | R-HSA-373752 | Netrin-1 signaling |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-375165 | NCAM signaling for neurite out-growth |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-388841 | Costimulation by the CD28 family |
| reactome | R-HSA-389356 | CD28 co-stimulation |
| reactome | R-HSA-389513 | CTLA4 inhibitory signaling |
| reactome | R-HSA-391160 | Signal regulatory protein family interactions |
| reactome | R-HSA-392518 | Signal amplification |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-3928664 | Ephrin signaling |
| reactome | R-HSA-3928664 | Ephrin signaling |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-418592 | ADP signalling through P2Y purinoceptor 1 |
| reactome | R-HSA-418885 | DCC mediated attractive signaling |
| reactome | R-HSA-418885 | DCC mediated attractive signaling |
| reactome | R-HSA-418886 | Netrin mediated repulsion signals |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO |
| reactome | R-HSA-430116 | GP1b-IX-V activation signalling |
| reactome | R-HSA-437239 | Recycling pathway of L1 |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-456926 | Thrombin signalling through proteinase activated receptors (PARs) |
| reactome | R-HSA-5205647 | Mitophagy |
| reactome | R-HSA-5218921 | VEGFR2 mediated cell proliferation |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5654726 | Negative regulation of FGFR1 signaling |
| reactome | R-HSA-5654727 | Negative regulation of FGFR2 signaling |
| reactome | R-HSA-5654732 | Negative regulation of FGFR3 signaling |
| reactome | R-HSA-5654733 | Negative regulation of FGFR4 signaling |
| reactome | R-HSA-5654736 | Signaling by FGFR1 |
| reactome | R-HSA-5654738 | Signaling by FGFR2 |
| reactome | R-HSA-5654741 | Signaling by FGFR3 |
| reactome | R-HSA-5654743 | Signaling by FGFR4 |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-5673000 | RAF activation |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5674135 | MAP2K and MAPK activation |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6802946 | Signaling by moderate kinase activity BRAF mutants |
| reactome | R-HSA-6802948 | Signaling by high-kinase activity BRAF mutants |
| reactome | R-HSA-6802949 | Signaling by RAS mutants |
| reactome | R-HSA-6802952 | Signaling by BRAF and RAF fusions |
| reactome | R-HSA-6802955 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| reactome | R-HSA-6802957 | Oncogenic MAPK signaling |
| reactome | R-HSA-6806834 | Signaling by MET |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-69231 | Cyclin D associated events in G1 |
| reactome | R-HSA-69236 | G1 Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76009 | Platelet Aggregation (Plug Formation) |
| reactome | R-HSA-8853659 | RET signaling |
| reactome | R-HSA-8874081 | MET activates PTK2 signaling |
| reactome | R-HSA-8875878 | MET promotes cell motility |
| reactome | R-HSA-8876384 | Listeria monocytogenes entry into host cells |
| reactome | R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells |
| reactome | R-HSA-8878159 | Transcriptional regulation by RUNX3 |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8934593 | Regulation of RUNX1 Expression and Activity |
| reactome | R-HSA-8934903 | Receptor Mediated Mitophagy |
| reactome | R-HSA-8940973 | RUNX2 regulates osteoblast differentiation |
| reactome | R-HSA-8941326 | RUNX2 regulates bone development |
| reactome | R-HSA-8941858 | Regulation of RUNX3 expression and activity |
| reactome | R-HSA-9006115 | Signaling by NTRK2 (TRKB) |
| reactome | R-HSA-9006921 | Integrin signaling |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9032500 | Activated NTRK2 signals through FYN |
| reactome | R-HSA-9034015 | Signaling by NTRK3 (TRKC) |
| reactome | R-HSA-9034015 | Signaling by NTRK3 (TRKC) |
| reactome | R-HSA-9603381 | Activated NTRK3 signals through PI3K |
| reactome | R-HSA-9603381 | Activated NTRK3 signals through PI3K |
| biocarta | achpathway | role of nicotinic acetylcholine receptors in the regulation of apoptosis |
| biocarta | agrpathway | agrin in postsynaptic differentiation |
| biocarta | at1rpathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling |
| biocarta | barrestinsrcpathway | roles of arrestin dependent recruitment of src kinases in gpcr signaling |
| biocarta | cblpathway | cbl mediated ligand-induced downregulation of egf receptors pathway |
| biocarta | cell2cellpathway | cell to cell adhesion signaling |
| biocarta | ecmpathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia |
| biocarta | edg1pathway | phospholipids as signalling intermediaries |
| biocarta | erkpathway | erk1/erk2 mapk signaling pathway |
| biocarta | gabapathway | gamma-aminobutyric acid receptor life cycle pathway |
| biocarta | hbxpathway | calcium signaling by hbx of hepatitis b virus |
| biocarta | integrinpathway | integrin signaling pathway |
| biocarta | mprpathway | how progesterone initiates the oocyte maturation |
| biocarta | pelp1pathway | pelp1 modulation of estrogen receptor activity |
| biocarta | pyk2pathway | links between pyk2 and map kinases |
| biocarta | sam68pathway | regulation of splicing through sam68 |
| biocarta | sprypathway | sprouty regulation of tyrosine kinase signals |
| biocarta | ucalpainpathway | ucalpain and friends in cell spread |
| biocarta | vegfpathway | vegf hypoxia and angiogenesis |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD185 | DMOG | 2 |
| iGMDRD96 | S-Trityl-L-cysteine | 1 |
| iGMDRD225 | AC1MD3YP | 1 |
| iGMDRD41 | Imatinib | 1 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD491 | TAE-684 | 2 |
| iGMDRD33 | Entinostat | 1 |
| iGMDRD493 | GSK269962A | 1 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD861 | BRD-K92856060 | 1 |
| iGMDRD446 | LY 2183240 | 6 |
| iGMDRD608 | Refametinib | 1 |
| iGMDRD66 | Doxorubicin | 1 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 1 |
| iGMDRD401 | Afatinib | 1 |
| iGMDRD778 | SCHEMBL13586708 | 1 |
| iGMDRD659 | Avagacestat (BMS-708163) | 1 |
| iGMDRD273 | Alvocidib | 1 |
| iGMDRD670 | ML 210 | 1 |
| iGMDRD144 | NSC95397 | 1 |
| iGMDRD1 | Nicotin-Amide | 1 |
| iGMDRD484 | Pluripotin | 5 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD414 | MST-312 | 1 |
| iGMDRD87 | Epigallocatechin-3-monogallate | 1 |
| iGMDRD141 | NSC48300 | 1 |
| iGMDRD625 | BRD-K84807411 | 1 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD241 | Sunitinib | 1 |
| iGMDRD705 | Nakiterpiosin | 6 |
| iGMDRD215 | CCT007093 | 1 |
| iGMDRD381 | Rucaparib | 1 |
| iGMDRD504 | Obatoclax | 1 |
| iGMDRD604 | 4449-51-8 | 1 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD450 | JNJ-26854165 | 1 |
| iGMDRD1036 | X17AAG | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SRC
CLASSFICATION
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.