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SRC

Summary: This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameSRC proto-oncogene, non-receptor tyrosine kinase OMIM IDMIM:190090 Ensembl IDEnsembl:ENSG00000197122 HGNC IDHGNC:HGNC:11283 PHARMGKB IDPA36111 Map Location20q11.23

Gene Categories:

DRUG RESISTANCE TYROSINE KINASE LIPID KINASE CLINICALLY ACTIONABLE PROTEASE TUMOR SUPPRESSOR KINASE DRUGGABLE GENOME RNA DIRECTED DNA POLYMERASE SERINE THREONINE KINASE

GO terms in SRC

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IEA	GO:0002102	podosome
CC	IEA	GO:0005634	nucleus
CC	IDA	GO:0005737	cytoplasm
CC	IDA	GO:0005739	mitochondrion
CC	IDA	GO:0005743	mitochondrial inner membrane
CC	IDA	GO:0005764	lysosome

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Gene expression in normal tissue: SRC

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SRC

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Database	Pathway ID	Pathway Des.
pid	ajdiss_2pathway	Posttranslational regulation of adherens junction stability and dissassembly
pid	alphasynuclein_pathway	Alpha-synuclein signaling
pid	ar_nongenomic_pathway	Nongenotropic Androgen signaling
pid	ar_tf_pathway	Regulation of Androgen receptor activity
pid	arf6_pathway	Arf6 signaling events
pid	avb3_integrin_pathway	Integrins in angiogenesis

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD185	DMOG	2
iGMDRD96	S-Trityl-L-cysteine	1
iGMDRD225	AC1MD3YP	1
iGMDRD41	Imatinib	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SRC

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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