GATA3
Summary: This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:131320 Ensembl IDEnsembl:ENSG00000107485 HGNC IDHGNC:HGNC:4172 PHARMGKB IDPA28586 Map Location10p14 | |||||
GO terms in GATA3
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | ISS | GO:0001709 | cell fate determination |
| BP | IEA | GO:0001764 | neuron migration |
| BP | IEA | GO:0001806 | type IV hypersensitivity |
| BP | IMP | GO:0001822 | kidney development |
Gene expression in normal tissue: GATA3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GATA3
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP3527 | Preimplantation Embryo |
| wikipathways | WP3893 | Development and heterogeneity of the ILC family |
| wikipathways | WP3946 | White fat cell differentiation |
| wikipathways | WP395 | IL-4 Signaling Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GATA3
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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