GATA3
Summary: This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| GATA binding protein 3 | MIM:131320 | Ensembl:ENSG00000107485 | HGNC:HGNC:4172 | PA28586 | 10p14 |
GO terms in GATA3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | ISS | GO:0001709 | cell fate determination |
| BP | IEA | GO:0001764 | neuron migration |
| BP | IEA | GO:0001806 | type IV hypersensitivity |
| BP | IMP | GO:0001822 | kidney development |
| BP | ISS | GO:0001823 | mesonephros development |
| BP | IEA | GO:0002088 | lens development in camera-type eye |
| BP | IEA | GO:0002572 | pro-T cell differentiation |
| BP | ISS | GO:0003180 | aortic valve morphogenesis |
| BP | ISS | GO:0003215 | cardiac right ventricle morphogenesis |
| BP | ISS | GO:0003281 | ventricular septum development |
| BP | IEA | GO:0006338 | chromatin remodeling |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006952 | defense response |
| BP | IEA | GO:0006959 | humoral immune response |
| BP | ISS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007411 | axon guidance |
| BP | IBA | GO:0007507 | heart development |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | ISS | GO:0008285 | negative regulation of cell proliferation |
| BP | ISS | GO:0008584 | male gonad development |
| BP | IEP | GO:0009615 | response to virus |
| BP | TAS | GO:0009653 | anatomical structure morphogenesis |
| BP | IEA | GO:0009791 | post-embryonic development |
| BP | IBA | GO:0009887 | animal organ morphogenesis |
| BP | IBA | GO:0009888 | tissue development |
| BP | IMP | GO:0009967 | positive regulation of signal transduction |
| BP | IEA | GO:0010332 | response to gamma radiation |
| BP | IMP | GO:0010595 | positive regulation of endothelial cell migration |
| BP | IEA | GO:0010975 | regulation of neuron projection development |
| BP | ISS | GO:0014065 | phosphatidylinositol 3-kinase signaling |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0030218 | erythrocyte differentiation |
| BP | ISS | GO:0031929 | TOR signaling |
| BP | IEA | GO:0032689 | negative regulation of interferon-gamma production |
| BP | IEA | GO:0032703 | negative regulation of interleukin-2 production |
| BP | ISS | GO:0032753 | positive regulation of interleukin-4 production |
| BP | IDA | GO:0033600 | negative regulation of mammary gland epithelial cell proliferation |
| BP | IEA | GO:0035162 | embryonic hemopoiesis |
| BP | IEP | GO:0035457 | cellular response to interferon-alpha |
| BP | IEA | GO:0035799 | ureter maturation |
| BP | IEA | GO:0035898 | parathyroid hormone secretion |
| BP | ISS | GO:0042035 | regulation of cytokine biosynthetic process |
| BP | ISS | GO:0042421 | norepinephrine biosynthetic process |
| BP | IEA | GO:0042472 | inner ear morphogenesis |
| BP | IEA | GO:0043370 | regulation of CD4-positive, alpha-beta T cell differentiation |
| BP | IEA | GO:0043523 | regulation of neuron apoptotic process |
| BP | IMP | GO:0043583 | ear development |
| BP | IEP | GO:0043627 | response to estrogen |
| BP | IEA | GO:0045061 | thymic T cell selection |
| BP | IEA | GO:0045064 | T-helper 2 cell differentiation |
| BP | IEA | GO:0045087 | innate immune response |
| BP | IBA | GO:0045165 | cell fate commitment |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | ISS | GO:0045582 | positive regulation of T cell differentiation |
| BP | IMP | GO:0045599 | negative regulation of fat cell differentiation |
| BP | IMP | GO:0045786 | negative regulation of cell cycle |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | ISS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0048468 | cell development |
| BP | IEA | GO:0048469 | cell maturation |
| BP | ISS | GO:0048485 | sympathetic nervous system development |
| BP | IEA | GO:0048538 | thymus development |
| BP | IBA | GO:0048565 | digestive tract development |
| BP | IEA | GO:0048589 | developmental growth |
| BP | IBA | GO:0048646 | anatomical structure formation involved in morphogenesis |
| BP | ISS | GO:0048646 | anatomical structure formation involved in morphogenesis |
| BP | IMP | GO:0050728 | negative regulation of inflammatory response |
| BP | ISS | GO:0050852 | T cell receptor signaling pathway |
| BP | IEA | GO:0051569 | regulation of histone H3-K4 methylation |
| BP | IMP | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IEA | GO:0060017 | parathyroid gland development |
| BP | ISS | GO:0060037 | pharyngeal system development |
| BP | ISS | GO:0060065 | uterus development |
| BP | IDA | GO:0060231 | mesenchymal to epithelial transition |
| BP | IEA | GO:0060374 | mast cell differentiation |
| BP | ISS | GO:0060676 | ureteric bud formation |
| BP | IEA | GO:0061085 | regulation of histone H3-K27 methylation |
| BP | ISS | GO:0061290 | canonical Wnt signaling pathway involved in metanephric kidney development |
| BP | IEP | GO:0071353 | cellular response to interleukin-4 |
| BP | IEP | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IEA | GO:0071442 | positive regulation of histone H3-K14 acetylation |
| BP | IEA | GO:0071599 | otic vesicle development |
| BP | IEA | GO:0071773 | cellular response to BMP stimulus |
| BP | ISS | GO:0072107 | positive regulation of ureteric bud formation |
| BP | ISS | GO:0072178 | nephric duct morphogenesis |
| BP | ISS | GO:0072179 | nephric duct formation |
| BP | ISS | GO:0072182 | regulation of nephron tubule epithelial cell differentiation |
| BP | IEA | GO:0072602 | interleukin-4 secretion |
| BP | IEA | GO:0072643 | interferon-gamma secretion |
| BP | IDA | GO:0072676 | lymphocyte migration |
| BP | IEA | GO:0090102 | cochlea development |
| BP | IEA | GO:1901536 | negative regulation of DNA demethylation |
| BP | TAS | GO:1902036 | regulation of hematopoietic stem cell differentiation |
| BP | IEA | GO:2000114 | regulation of establishment of cell polarity |
| BP | IMP | GO:2000146 | negative regulation of cell motility |
| BP | IMP | GO:2000352 | negative regulation of endothelial cell apoptotic process |
| BP | IEA | GO:2000553 | positive regulation of T-helper 2 cell cytokine production |
| BP | ISS | GO:2000607 | negative regulation of cell proliferation involved in mesonephros development |
| BP | IMP | GO:2000611 | positive regulation of thyroid hormone generation |
| BP | IEA | GO:2000617 | positive regulation of histone H3-K9 acetylation |
| BP | IDA | GO:2000664 | positive regulation of interleukin-5 secretion |
| BP | IDA | GO:2000667 | positive regulation of interleukin-13 secretion |
| BP | IMP | GO:2000667 | positive regulation of interleukin-13 secretion |
| BP | IMP | GO:2000679 | positive regulation of transcription regulatory region DNA binding |
| BP | IMP | GO:2000683 | regulation of cellular response to X-ray |
| BP | ISS | GO:2000703 | negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation |
| BP | ISS | GO:2000734 | negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation |
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| MF | IDA | GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0000987 | proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0001076 | transcription factor activity, RNA polymerase II transcription factor binding |
| MF | IBA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IMP | GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0001158 | enhancer sequence-specific DNA binding |
| MF | TAS | GO:0003677 | DNA binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IMP | GO:0003700 | DNA-binding transcription factor activity |
| MF | IDA | GO:0003713 | transcription coactivator activity |
| MF | IEA | GO:0005134 | interleukin-2 receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IEA | GO:0046983 | protein dimerization activity |
| MF | IDA | GO:0070888 | E-box binding |
| MF | IPI | GO:0071837 | HMG box domain binding |
Gene expression in normal tissue: GATA3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GATA3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP3527 | Preimplantation Embryo |
| wikipathways | WP3893 | Development and heterogeneity of the ILC family |
| wikipathways | WP3946 | White fat cell differentiation |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP4149 | White fat cell differentiation |
| wikipathways | WP4211 | Transcriptional cascade regulating adipogenesis |
| wikipathways | WP61 | Notch Signaling Pathway |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa05321 | Inflammatory bowel disease (IBD) - Homo sapiens (human) |
| pid | cmyb_pathway | C-MYB transcription factor network |
| pid | il27pathway | IL27-mediated signaling events |
| pid | nfat_tfpathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| pid | notch_pathway | Notch signaling pathway |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| biocarta | gata3pathway | gata3 participate in activating the th2 cytokine genes expression |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939211 | ESR-mediated signaling |
| reactome | R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| reactome | R-HSA-9018519 | Estrogen-dependent gene expression |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD617 | BRD-K04800985 | 1 |
| iGMDRD540 | Alisertib | 1 |
| iGMDRD750 | TRIAZOLOTHIADIAZINE | 1 |
| iGMDRD39 | Pyrimethamine | 1 |
| iGMDRD435 | BI-2536 | 1 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD324 | CI-1040 | 1 |
| iGMDRD569 | MOMELOTINIB | 1 |
| iGMDRD256 | NVP-231 | 1 |
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD664 | Dinaciclib | 1 |
| iGMDRD87 | Epigallocatechin-3-monogallate | 1 |
| iGMDRD9 | Aromatase ihibitor | 2 |
| iGMDRD421 | AZD7762 | 1 |
| iGMDRD264 | Bryostatin 1 | 1 |
| iGMDRD990 | PL.DI | 1 |
| iGMDRD552 | AZD-1775 | 1 |
| iGMDRD787 | PF 184 | 1 |
| iGMDRD479 | Veliparib | 1 |
| iGMDRD215 | CCT007093 | 1 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 1 |
| iGMDRD358 | Semagacestat | 1 |
| iGMDRD273 | Alvocidib | 1 |
| iGMDRD12 | Bicalutamide | 1 |
| iGMDRD97 | Bexarotene | 1 |
| iGMDRD199 | RG108 | 1 |
| iGMDRD489 | GSK-461364 | 1 |
| iGMDRD484 | Pluripotin | 1 |
| iGMDRD75 | Lovastatin | 1 |
| iGMDRD354 | Midostaurin | 1 |
| iGMDRD323 | Leptomycin B | 1 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD371 | THR1 Inhibitor | 1 |
| iGMDRD574 | Ruxolitinib | 1 |
| iGMDRD272 | GSK-3 Inhibitor IX | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GATA3
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.