SLC30A2
Summary: The protein encoded by this gene is a zinc transporter that acts as a homodimer. The encoded protein plays a role in secreting zinc into breast milk. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier family 30 member 2 | MIM:609617 | Ensembl:ENSG00000158014 | HGNC:HGNC:11013 | PA35883 | 1p36.11 |
Gene Categories:
TRANSPORTERGO terms in SLC30A2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0010043 | response to zinc ion |
| BP | IBA | GO:0061088 | regulation of sequestering of zinc ion |
| BP | IDA | GO:0061090 | positive regulation of sequestering of zinc ion |
| BP | IBA | GO:0071577 | zinc ion transmembrane transport |
| BP | IEA | GO:0071577 | zinc ion transmembrane transport |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | HDA | GO:0005765 | lysosomal membrane |
| CC | IDA | GO:0005770 | late endosome |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IBA | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| MF | IBA | GO:0005385 | zinc ion transmembrane transporter activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: SLC30A2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC30A2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425366 | Transport of bile salts and organic acids, metal ions and amine compounds |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
| reactome | R-HSA-425410 | Metal ion SLC transporters |
| reactome | R-HSA-435354 | Zinc transporters |
| reactome | R-HSA-435368 | Zinc efflux and compartmentalization by the SLC30 family |
| wikipathways | WP3529 | Zinc homeostasis |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC30A2
CLASSFICATION
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