SLC30A2
Summary: The protein encoded by this gene is a zinc transporter that acts as a homodimer. The encoded protein plays a role in secreting zinc into breast milk. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:609617 Ensembl IDEnsembl:ENSG00000158014 HGNC IDHGNC:HGNC:11013 PHARMGKB IDPA35883 Map Location1p36.11 | |||||
Gene Categories:
TRANSPORTERGO terms in SLC30A2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0010043 | response to zinc ion |
| BP | IBA | GO:0061088 | regulation of sequestering of zinc ion |
| BP | IDA | GO:0061090 | positive regulation of sequestering of zinc ion |
| BP | IBA | GO:0071577 | zinc ion transmembrane transport |
| BP | IEA | GO:0071577 | zinc ion transmembrane transport |
| CC | IDA | GO:0005737 | cytoplasm |
Gene expression in normal tissue: SLC30A2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC30A2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425366 | Transport of bile salts and organic acids, metal ions and amine compounds |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
| reactome | R-HSA-425410 | Metal ion SLC transporters |
| reactome | R-HSA-435354 | Zinc transporters |
| reactome | R-HSA-435368 | Zinc efflux and compartmentalization by the SLC30 family |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD284 | Palbociclib | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC30A2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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