EXOC7
Summary: The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:608163 Ensembl IDEnsembl:ENSG00000182473 HGNC IDHGNC:HGNC:23214 PHARMGKB IDPA134988420 Map Location17q25.1 | |||||
GO terms in EXOC7
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000145 | exocyst |
| CC | IDA | GO:0005815 | microtubule organizing center |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0032584 | growth cone membrane |
Gene expression in normal tissue: EXOC7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EXOC7
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| pid | arf6_traffickingpathway | Arf6 trafficking events |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | insulin_pathway | Insulin Pathway |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| reactome | R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD284 | Palbociclib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EXOC7
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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