ADAR

Summary: This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameadenosine deaminase, RNA specific
OMIM IDMIM:146920
Ensembl IDEnsembl:ENSG00000160710
HGNC IDHGNC:HGNC:225
PHARMGKB IDPA24555
Map Location1q21.3

Gene Categories:

KINASE

GO terms in ADAR


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0001649 osteoblast differentiation
BP IEA GO:0001701 in utero embryonic development
BP IEA GO:0002244 hematopoietic progenitor cell differentiation
BP IEA GO:0002566 somatic diversification of immune receptors via somatic mutation
BP IBA GO:0006382 adenosine to inosine editing
BP IDA GO:0006382 adenosine to inosine editing
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Gene expression in normal tissue: ADAR

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 15

Gene-drug pathway distribution

ERK MAPK signaling4RTK signaling2DNA replication2JNK and p38 signaling2Other, kinases1Biosynthesis of alkaloids derived from shikimate pathway1Protein stability and degradation1ABL signaling1Cell cycle1

Pathways in ADAR


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Database
Pathway ID
Pathway Des.
biocarta antisensepathway antisense pathway
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-168256 Immune System
reactome R-HSA-75064 mRNA Editing: A to I Conversion
reactome R-HSA-75072 mRNA Editing
reactome R-HSA-75102 C6 deamination of adenosine
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD190 Nilotinib 1
iGMDRD454 JNK Inhibitor VIII 1
iGMDRD608 Refametinib 1
iGMDRD399 Selumetinib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADAR

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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