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ADAR

Summary: This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameadenosine deaminase, RNA specific OMIM IDMIM:146920 Ensembl IDEnsembl:ENSG00000160710 HGNC IDHGNC:HGNC:225 PHARMGKB IDPA24555 Map Location1q21.3

Gene Categories:

KINASE

GO terms in ADAR

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0001649	osteoblast differentiation
BP	IEA	GO:0001701	in utero embryonic development
BP	IEA	GO:0002244	hematopoietic progenitor cell differentiation
BP	IEA	GO:0002566	somatic diversification of immune receptors via somatic mutation
BP	IBA	GO:0006382	adenosine to inosine editing
BP	IDA	GO:0006382	adenosine to inosine editing

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Gene expression in normal tissue: ADAR

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ADAR

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Database	Pathway ID	Pathway Des.
biocarta	antisensepathway	antisense pathway
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-168256	Immune System
reactome	R-HSA-75064	mRNA Editing: A to I Conversion
reactome	R-HSA-75072	mRNA Editing
reactome	R-HSA-75102	C6 deamination of adenosine

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD190	Nilotinib	1
iGMDRD454	JNK Inhibitor VIII	1
iGMDRD608	Refametinib	1
iGMDRD399	Selumetinib	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADAR

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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