ADAR
Summary: This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| adenosine deaminase, RNA specific | MIM:146920 | Ensembl:ENSG00000160710 | HGNC:HGNC:225 | PA24555 | 1q21.3 |
Gene Categories:
KINASEGO terms in ADAR
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001649 | osteoblast differentiation |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IEA | GO:0002244 | hematopoietic progenitor cell differentiation |
| BP | IEA | GO:0002566 | somatic diversification of immune receptors via somatic mutation |
| BP | IBA | GO:0006382 | adenosine to inosine editing |
| BP | IDA | GO:0006382 | adenosine to inosine editing |
| BP | IMP | GO:0006382 | adenosine to inosine editing |
| BP | TAS | GO:0006382 | adenosine to inosine editing |
| BP | IBA | GO:0006396 | RNA processing |
| BP | IEA | GO:0006397 | mRNA processing |
| BP | IMP | GO:0009615 | response to virus |
| BP | IDA | GO:0016553 | base conversion or substitution editing |
| BP | IEA | GO:0030218 | erythrocyte differentiation |
| BP | IDA | GO:0031054 | pre-miRNA processing |
| BP | IDA | GO:0035280 | miRNA loading onto RISC involved in gene silencing by miRNA |
| BP | IDA | GO:0035455 | response to interferon-alpha |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation |
| BP | IMP | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation |
| BP | IDA | GO:0045070 | positive regulation of viral genome replication |
| BP | IMP | GO:0045070 | positive regulation of viral genome replication |
| BP | IEA | GO:0045071 | negative regulation of viral genome replication |
| BP | TAS | GO:0045087 | innate immune response |
| BP | IEA | GO:0051607 | defense response to virus |
| BP | IEA | GO:0060216 | definitive hemopoiesis |
| BP | TAS | GO:0060337 | type I interferon signaling pathway |
| BP | IEA | GO:0060339 | negative regulation of type I interferon-mediated signaling pathway |
| BP | IEA | GO:0061484 | hematopoietic stem cell homeostasis |
| BP | IEA | GO:0098586 | cellular response to virus |
| BP | IEA | GO:1900369 | negative regulation of RNA interference |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0044530 | supraspliceosomal complex |
| MF | IEA | GO:0003677 | DNA binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003725 | double-stranded RNA binding |
| MF | IBA | GO:0003726 | double-stranded RNA adenosine deaminase activity |
| MF | IDA | GO:0003726 | double-stranded RNA adenosine deaminase activity |
| MF | NAS | GO:0003726 | double-stranded RNA adenosine deaminase activity |
| MF | TAS | GO:0003726 | double-stranded RNA adenosine deaminase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008251 | tRNA-specific adenosine deaminase activity |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: ADAR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADAR
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | antisensepathway | antisense pathway |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-75064 | mRNA Editing: A to I Conversion |
| reactome | R-HSA-75072 | mRNA Editing |
| reactome | R-HSA-75102 | C6 deamination of adenosine |
| reactome | R-HSA-77042 | Formation of editosomes by ADAR proteins |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-909733 | Interferon alpha/beta signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2006 | miR-targeted genes in squamous cell - TarBase |
| kegg | hsa04623 | Cytosolic DNA-sensing pathway - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD190 | Nilotinib | 1 |
| iGMDRD454 | JNK Inhibitor VIII | 1 |
| iGMDRD608 | Refametinib | 1 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD146 | Elesclomol | 1 |
| iGMDRD63 | Camptothecin | 1 |
| iGMDRD125 | BIRB-796 | 1 |
| iGMDRD284 | Palbociclib | 1 |
| iGMDRD160 | Cis-Platin | 1 |
| iGMDRD283 | Bosutinib | 1 |
| iGMDRD50 | Cytarabine | 1 |
| iGMDRD313 | Axitinib | 2 |
| iGMDRD467 | Motesanib | 1 |
| iGMDRD324 | CI-1040 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADAR
CLASSFICATION
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