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STK11

Summary: This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameserine/threonine kinase 11 OMIM IDMIM:602216 Ensembl IDEnsembl:ENSG00000118046 HGNC IDHGNC:HGNC:11389 PHARMGKB IDPA36198 Map Location19p13.3

Gene Categories:

DRUGGABLE GENOME SERINE THREONINE KINASE TUMOR SUPPRESSOR KINASE CLINICALLY ACTIONABLE

GO terms in STK11

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005654	nucleoplasm
CC	TAS	GO:0005654	nucleoplasm
CC	IDA	GO:0005737	cytoplasm
CC	IDA	GO:0005739	mitochondrion
CC	IDA	GO:0005829	cytosol

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Gene expression in normal tissue: STK11

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STK11

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Database	Pathway ID	Pathway Des.
wikipathways	WP1403	AMP-activated Protein Kinase (AMPK) Signaling
wikipathways	WP1984	Integrated Breast Cancer Pathway
wikipathways	WP2571	Polycystic Kidney Disease Pathway
wikipathways	WP3595	mir-124 predicted interactions with cell cycle and differentiation
wikipathways	WP3878	ATM Signaling Network in Development and Disease
wikipathways	WP3932	Focal Adhesion-PI3K-Akt-mTOR-signaling pathway

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD64	Parbendazole	2
iGMDRD190	Nilotinib	1
iGMDRD524	ISX-9	3
iGMDRD874	BRD8958	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STK11

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.