iGMDRD54

Canonical SMILES: C1=CC=C(C=C1)CCN=C(N)N=C(N)N

InChI: InChI=1S/C10H15N5/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H6,11,12,13,14,15)

InChI Key: ICFJFFQQTFMIBG-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
KEGG Drug ID
DRUGBANK ID
Drug Status
Drug targets (TTD)
Drug Type
Standard NamePhenformin
CHEMBLCHEMBL170988
Pubchem CID8249
KEGG Drug IDD08351
DRUGBANK IDDB00914
Drug StatusAlone
Drug targets (TTD)DAP000206
Drug TypeSmall Molecule




Drug Synonyms:

Phenformin (BAN)

Drug-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Breast Carcinoma model num: 1BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: Colorectal Adenocarcinoma (COADREAD) model num: 1LYMPtissue: LYMP cancer: LYMPH model num: 0LYMPHtissue: LYMPH cancer: Diffuse Large B-Cell Lymphoma (DLBCL) model num: 1BONtissue: BON cancer: BONE model num: 0BONEtissue: BONE cancer: Acute Myeloid Leukemia (AML) model num: 1SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Cutaneous Melanoma (SKCM) model num: 1LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Lung Adenocarcinoma (LUAD) model num: 2LUNGtissue: LUNG cancer: Adenoid Cystic Carcinoma of the Lung (LUACC) model num: 1

Drug-gene pathway enrichments

8reactome: Signal Transduction6reactome: RNA Polymerase II Transcription6reactome: Developmental Biology6reactome: Gene expression (Transcription)6reactome: Generic Transcription Pathway4reactome: Chromatin organization4reactome: Chromatin modifying enzymes3reactome: Metabolism3reactome: Axon guidance3kegg: MicroRNAs in cancer - Homo sapiens (human)

Drug-gene GO enrichments

7MF: protein binding7CC: nucleoplasm6CC: nucleus4MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding4CC: cytosol4MF: DNA binding4MF: transcription coactivator activity3CC: cytoplasm3BP: transcription, DNA-templated3BP: positive regulation of transcription, DNA-templated

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
8289 ARID1A 1
9757 KMT2B 2
1387 CREBBP 1
6794 STK11 3
Showing 1 to 4 of 7 rows

Gene in drug-gene network: Network Plot

Models in Phenformin

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
MUT(MLL2) mix GDSC undefined PANCAN Phenformin sensitivity in vitro
AMP(CLTC,PPM1D) mix GDSC BREAST Breast Carcinoma Phenformin sensitivity in vitro
MUT(TRIO) mix GDSC BOWEL Colorectal Adenocarcinoma (COADREAD) Phenformin sensitivity in vitro
¬DEL(16q23.1)&PWU(Wnt)|MUT(MLL2)&PWD(MAPK_PI3K) mix GDSC LYMPH Diffuse Large B-Cell Lymphoma (DLBCL) Phenformin sensitivity in vitro
MUT(CREBBP)&¬MUT(NRAS)&¬MUT(ARID1A) mix GDSC BONE Acute Myeloid Leukemia (AML) Phenformin sensitivity in vitro
MUT(EZH2) mix GDSC SKIN Cutaneous Melanoma (SKCM) Phenformin sensitivity in vitro
DEL(STK11) gene 23352126 LUNG Lung Adenocarcinoma (LUAD) Phenformin sensitivity in vivo
ONCO-MUT(STK11) gene 23352126 LUNG Lung Adenocarcinoma (LUAD) Phenformin sensitivity in vivo
MUT(STK11)|DEL(STK11) gene 23352126 LUNG Adenoid Cystic Carcinoma of the Lung (LUACC) phenformin sensitivity in vivo
Showing 1 to 9 of 9 rows

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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.