TRIO


Summary: This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
trio Rho guanine nucleotide exchange factorMIM:601893Ensembl:ENSG00000038382HGNC:HGNC:12303PA369825p15.2

GO terms in TRIO


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0004674protein serine/threonine kinase activity
MFTASGO:0005085guanyl-nucleotide exchange factor activity
MFTASGO:0005089Rho guanyl-nucleotide exchange factor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
CCTASGO:0005829cytosol
BPIEAGO:0006468protein phosphorylation
BPTASGO:0007185transmembrane receptor protein tyrosine phosphatase signaling pathway
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIEAGO:0035023regulation of Rho protein signal transduction
BPTASGO:0043065positive regulation of apoptotic process
BPISSGO:0045599negative regulation of fat cell differentiation
BPTASGO:0051056regulation of small GTPase mediated signal transduction

Gene expression in normal tissue: TRIO

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TRIO


DatabasePathway IDPathway Des.
pidnetrin_pathwayNetrin-mediated signaling events
pidrac1_reg_pathwayRegulation of RAC1 activity
pidrhoa_reg_pathwayRegulation of RhoA activity
wikipathwaysWP2038Regulation of Microtubule Cytoskeleton
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-193648NRAGE signals death through JNK
reactomeR-HSA-193704p75 NTR receptor-mediated signalling
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194840Rho GTPase cycle
reactomeR-HSA-204998Cell death signalling via NRAGE, NRIF and NADE
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373752Netrin-1 signaling
reactomeR-HSA-373752Netrin-1 signaling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-416482G alpha (12/13) signalling events
reactomeR-HSA-418885DCC mediated attractive signaling
reactomeR-HSA-418885DCC mediated attractive signaling
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-73887Death Receptor Signalling
biocartamyosinpathwaypkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase
biocartarac1pathwayrac1 cell motility signaling pathway
biocartarhopathwayrho cell motility signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD499PDMP2
iGMDRD351GW843682X2
iGMDRD123Isoevodiamine4
iGMDRD154NSC237662
iGMDRD48Dexamethasone3
iGMDRD84Lovastatin acid3
iGMDRD248BRD43542
iGMDRD512nutlin 32
iGMDRD584VER 1550081
iGMDRD116CD4373
iGMDRD560MK-22066
iGMDRD414MST-3123
iGMDRD871BRD63683
iGMDRD286Nsc 6328394
iGMDRD329Merck603
iGMDRD552AZD-17753
iGMDRD246NPC262
iGMDRD300Tozasertib2
iGMDRD505Pevonedistat5
iGMDRD353PD03259011
iGMDRD137Indisulam3
iGMDRD202Curcumin1
iGMDRD103SN-386
iGMDRD705Nakiterpiosin3
iGMDRD6AM-5802
iGMDRD267Oligomycin A3
iGMDRD446LY 21832404
iGMDRD193Fqi12
iGMDRD61Kinetin riboside3
iGMDRD130Enzastaurin1
iGMDRD433Lexibulin1
iGMDRD151CHM-12
iGMDRD126Tipifarnib5
iGMDRD54Phenformin1
iGMDRD772BRD47702
iGMDRD420Leucascandrolide A3
iGMDRD427ABT7373
iGMDRD670ML 2103
iGMDRD781Sirolimus3
iGMDRD494Neopeltolide2
iGMDRD887Compound 23 citrate3
iGMDRD399Selumetinib3
iGMDRD188Piperlongumine2
iGMDRD398Sepantronium1
iGMDRD506Fedratinib6
iGMDRD577BIX012946
iGMDRD369TGX-1152
iGMDRD64Parbendazole2
iGMDRD23Gossypol5
iGMDRD356PNU-746542
iGMDRD255SB2250023
iGMDRD207Capsaicin1
iGMDRD187BRD98762
iGMDRD870BRD636101
iGMDRD1019TL-2-1051

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TRIO

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