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TRIO

Summary: This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nametrio Rho guanine nucleotide exchange factor OMIM IDMIM:601893 Ensembl IDEnsembl:ENSG00000038382 HGNC IDHGNC:HGNC:12303 PHARMGKB IDPA36982 Map Location5p15.2

Gene Categories:

DRUGGABLE GENOME SERINE THREONINE KINASE KINASE

GO terms in TRIO

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IEA	GO:0004674	protein serine/threonine kinase activity
MF	TAS	GO:0005085	guanyl-nucleotide exchange factor activity
MF	TAS	GO:0005089	Rho guanyl-nucleotide exchange factor activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
CC	TAS	GO:0005829	cytosol

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Gene expression in normal tissue: TRIO

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TRIO

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Database	Pathway ID	Pathway Des.
pid	netrin_pathway	Netrin-mediated signaling events
pid	rac1_reg_pathway	Regulation of RAC1 activity
pid	rhoa_reg_pathway	Regulation of RhoA activity
wikipathways	WP2038	Regulation of Microtubule Cytoskeleton
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1266738	Developmental Biology

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD499	PDMP	2
iGMDRD351	GW843682X	2
iGMDRD123	Isoevodiamine	4
iGMDRD154	NSC23766	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TRIO

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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