iGMDRD333

Canonical SMILES: C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F

InChI: InChI=1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+

InChI Key: JLOXTZFYJNCPIS-FYWRMAATSA-N

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Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameMEK Inhibitor
CHEMBLCHEMBL261237
Pubchem CID9549280
Drug StatusFamily
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

23reactome: Signal Transduction12reactome: Signaling by Receptor Tyrosine Kinases11kegg: Pathways in cancer - Homo sapiens (human)11reactome: Diseases of signal transduction11wikipathways: Signaling Pathways in Glioblastoma11reactome: Disease10kegg: MAPK signaling pathway - Homo sapiens (human)10reactome: MAPK family signaling cascades10kegg: FoxO signaling pathway - Homo sapiens (human)10netpath: EGFR1

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
3845 KRAS 59
4771 NF2 2
5605 MAP2K2 10
6794 STK11 6
Showing 1 to 4 of 15 rows rows per page

Gene in drug-gene network: Network Plot

Models in MEK Inhibitor

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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